A comparative insight into the mechanical properties, antibacterial potential, and cytotoxicity profile of nano-hydroxyapatite and nano-whitlockite-incorporated poly-L-lactic acid for bone tissue engineering

Nazir, Farzana; Abbas, L.; Iqbal, Mudassir

doi:10.1007/s13204-021-02223-6

Cited by 6 publications

(4 citation statements)

References 91 publications

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“…coli, cryogels comprising a combination of whitlockite and drug (PCWD) demonstrated considerable growth inhibition zones (4.19 ± 3.55 cm) in contrast to drug-treated (3.34 ± 3.2 cm) or whitlockite-incorporated cryogel (PCW4) (2.84 ± 2.6 cm). It was intriguing to observe that PCW4 exhibited inhibition in the absence of the drug, likely due to the antibacterial properties of WNAs. , These results also validated the ciprofloxacin release pattern from the developed cryogels, thus indicating their promising role in treating wound tissues or postsurgical conditions.…”

Section: Resultssupporting

confidence: 52%

“…It was intriguing to observe that PCW4 exhibited inhibition in the absence of the drug, likely due to the antibacterial properties of WNAs. 100,101 These results also validated the ciprofloxacin release pattern from the developed cryogels, thus indicating their promising role in treating wound tissues or postsurgical conditions.…”

Section: Evaluation Of Drug Release Antibacterialsupporting

confidence: 62%

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Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing

Kumar,

Bose,

Kumar

et al. 2024

Biomacromolecules

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Immediate control of excessive bleeding and prevention of infections are of utmost importance in the management of wounds. Cryogels have emerged as promising materials for the rapid release of medication and achieving hemostasis. However, their quick release properties pose the challenge of exposing patients to high concentrations of drugs. In this study, hybrid nanocomposites were developed to address this issue by combining poly(vinyl alcohol) and κ-carrageenan with whitlockite nanoapatite (WNA) particles and ciprofloxacin, aiming to achieve rapid hemostasis and sustained antibacterial effects. A physically cross-linked cryogel was obtained by subjecting a blend of poly(vinyl alcohol) and κ-carrageenan to successive freezing−thawing cycles, followed by the addition of WNA. Furthermore, ciprofloxacin was introduced into the cryogel matrix for subsequent evaluation of its wound healing properties. The resulting gel system exhibited a 3D microporous structure and demonstrated excellent swelling, low cytotoxicity, and outstanding mechanical properties. These characteristics were evaluated through analytical and rheological experiments. The nanocomposite cryogel with 4% whitlockite showed extended drug release of 71.21 ± 3.5% over 21 days and antibacterial activity with a considerable growth inhibition zone (4.19 ± 3.55 cm). Experiments on a rat model demonstrated a rapid hemostasis property of cryogels within an average of 83 ± 4 s and accelerated the process of wound healing with 96.34% contraction compared to the standard, which exhibited only ∼78% after 14 days. The histopathological analysis revealed that the process of epidermal re-epithelialization took around 14 days following the skin incision. The cryogel loaded with WNAs and ciprofloxacin holds great potential for strategic utilization in wound management applications as an effective material for hemostasis and anti-infection purposes.

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Section: Resultssupporting

confidence: 52%

Section: Evaluation Of Drug Release Antibacterialsupporting

confidence: 62%

Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing

Kumar,

Bose,

Kumar

et al. 2024

Biomacromolecules

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“…Such conclusions were made in numerous studies, where Mg-WH was used in its pure form or in the form of composites. 10,11,[13][14][15][16][17][18][19][20] Although ionic substitutions have been widely investigated in conventionally used CPs, 21 studies on ion-substituted Mg-WH are almost absent, but the rare exception is a study by Yang et al, 22 who prepared and applied Eu 3+ /Tb 3+ -doped Mg-WH nanocrystals for bone reconstruction and bioimaging. Despite the fact that the first row transition metal (TM) ions have comparable size with Mg 2+ ions, 23 there are just a couple of studies on materials with a WH crystal structure, where Mg is replaced with other divalent cations.…”

Section: Introductionmentioning

confidence: 99%

“…Such conclusions were made in numerous studies, where Mg-WH was used in its pure form or in the form of composites. 10,11,13–20…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of the formation, structural and morphological properties of zinc whitlockite (Ca₁₈Zn₂(HPO₄)₂(PO₄)₁₂) synthesized via a phase transformation process under hydrothermal conditions

et al. 2022

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The influence of degradation in different pH buffer solutions on the optical and durability properties of Monocryl suture: (an in vitro study)

et al. 2023

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The objective of this work is to investigate the hydrolytic degradation of the Monocryl (PGA/PCL) surgical suture in different pH buffer solutions, and its correlation with the structural alterations the material undergoes. To this end, an in vitro degradation study was conducted under acidic (pH = 2), physiological (pH = 7.4), and alkaline (pH = 8.5) conditions at 37 °C, over 25 days. Changes in the swelling rate, structural and mechanical properties of the Monocryl sample with the degradation time were characterized, from which the related degradation mechanism of the material was concluded. Results showed that the structural values of the Monocryl sample were more sensitive in the alkaline medium than the acidic and neutral ones. It exhibited a reduction in birefringence values by 11.5% from the original one in the buffer solution of pH = 8.5, only 4% at pH = 2, and 2.6% at pH = 7.4, after 20 days of degradation durations. Over the same time period, mechanical loss in neutral, acidic, and alkaline media was decreased to 19, 14.9, and 8.3%, respectively. The obtained results revealed that the Monocryl suture exhibits enhanced degradation properties in neutral conditions rather than both acidic and alkaline ones, with a more homogeneous degradation behavior during the degradation process. Graphical abstract

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A comparative insight into the mechanical properties, antibacterial potential, and cytotoxicity profile of nano-hydroxyapatite and nano-whitlockite-incorporated poly-L-lactic acid for bone tissue engineering

Cited by 6 publications

References 91 publications

Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing

Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing

Peculiarities of the formation, structural and morphological properties of zinc whitlockite (Ca₁₈Zn₂(HPO₄)₂(PO₄)₁₂) synthesized via a phase transformation process under hydrothermal conditions

The influence of degradation in different pH buffer solutions on the optical and durability properties of Monocryl suture: (an in vitro study)

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A comparative insight into the mechanical properties, antibacterial potential, and cytotoxicity profile of nano-hydroxyapatite and nano-whitlockite-incorporated poly-L-lactic acid for bone tissue engineering

Cited by 6 publications

References 91 publications

Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing

Nanoapatite-Loaded κ-Carrageenan/Poly(vinyl alcohol)-Based Injectable Cryogel for Hemostasis and Wound Healing

Peculiarities of the formation, structural and morphological properties of zinc whitlockite (Ca18Zn2(HPO4)2(PO4)12) synthesized via a phase transformation process under hydrothermal conditions

The influence of degradation in different pH buffer solutions on the optical and durability properties of Monocryl suture: (an in vitro study)

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Peculiarities of the formation, structural and morphological properties of zinc whitlockite (Ca₁₈Zn₂(HPO₄)₂(PO₄)₁₂) synthesized via a phase transformation process under hydrothermal conditions