A comparative in-vitro study on antimicrobial efficacy of on-market alcohol-based hand washing sanitizers towards combating microbes and its application in combating Covid-19 global outbreak

Vuai, Said; Sahini, Mtabazi G.; Sule, Khalfani Salim; Ripanda, Asha; Miraji, Hossein

doi:10.1016/j.heliyon.2022.e11689

Cited by 6 publications

(11 citation statements)

References 36 publications

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“…Popular sanitizers on the market are based on alcohols, typically ethanol and isopropanol with the concentrations of 60%-95%. In a previous research, agar diffusion assay of alcohol-based sanitizers confirmed the antibacterial activity of ethanol against various types of bacteria [52]. In this study, agar well diffusion test showed clear inhibition zones of ethanol against E. coli and S. aureus bacteria (figure 5).…”

Section: Antibacterial Property Of Go-zno Hydrogelsupporting

confidence: 78%

“…Beside antibiotic drugs, alcohol-based sanitizers have become important to prevent the spread of infectious diseases. As a first line of defence against Covid-19 pandemic, alcohol-based agents containing ethanol 80% or isopropanol 75% are recommended for hand sanitization and community hygiene [50][51][52]. Popular sanitizers on the market are based on alcohols, typically ethanol and isopropanol with the concentrations of 60%-95%.…”

Section: Antibacterial Property Of Go-zno Hydrogelmentioning

confidence: 99%

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Sonochemical synthesis of bioinspired graphene oxide–zinc oxide hydrogel for antibacterial painting on biodegradable polylactide film

Le,

Nguyen,

Nguyen

et al. 2024

Nanotechnology

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Graphene oxide nanosheet (GO) is a multifunctional platform for binding with nanoparticles and stacking with two dimensional substrates. In this study, GO nanosheets were sonochemically decorated with zinc oxide nanoparticles (ZnO) and self-assembled into a hydrogel of GO-ZnO nanocomposite. The GO-ZnO hydrogel structure is a bioinspired approach for preserving graphene-based nanosheets from van der Waals stacking. X-ray diffraction analysis (XRD) showed that the sonochemical synthesis led to the formation of ZnO crystals on GO platforms. High water content (97.2 %) of GO-ZnO hydrogel provided good property of ultrasonic dispersibility in water. Ultraviolet-visible spectroscopic analysis (UV-Vis) revealed that optical band gap energy of ZnO nanoparticles (~ 3.2 eV) GO-ZnO nanosheets (~ 2.83 eV). Agar well diffusion tests presented effective antibacterial activities of GO-ZnO hydrogel against gram-negative bacteria (E. coli) and gram-positive bacteria (S. aureus). Especially, GO-ZnO hydrogel was directly used for brush painting on biodegradable polylactide (PLA) thin films. Graphene-based nanosheets with large surface area are key to van der Waals stacking and adhesion of GO-ZnO coating to the PLA substrate. The GO-ZnO/PLA films were characterized using photography, light transmittance spectroscopy, coating stability, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopic mapping (EDS), antibacterial test and mechanical tensile measurement. Specifically, GO-ZnO coating on PLA substrate exhibited stability in aqueous food simulants for packaging application. GO-ZnO coating inhibited the infectious growth of E. coli biofilm. GO-ZnO/PLA films had strong tensile strength and elastic modulus. As a result, the investigation of antibacterial GO-ZnO hydrogel and GO-ZnO coating on PLA film is fundamental for sustainable development of packaging and biomedical applications.

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Section: Antibacterial Property Of Go-zno Hydrogelsupporting

confidence: 78%

Section: Antibacterial Property Of Go-zno Hydrogelmentioning

confidence: 99%

Sonochemical synthesis of bioinspired graphene oxide–zinc oxide hydrogel for antibacterial painting on biodegradable polylactide film

Le,

Nguyen,

Nguyen

et al. 2024

Nanotechnology

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“…This prophylactic measure not only helps safeguard the user from potential infection by these pathogenic microorganisms but also contributes to preventing their transmission, thereby reducing the risk of infectious disease propagation [2]. Moreover, due to the global pandemic caused by SARS-CoV-2, this practice has been increasingly adopted worldwide, due to the continuous and on-the-go necessity for hand hygiene [3]. Therefore, dermal sanitizers that allow for direct application to the skin without the need for rinsing have been developed and optimized, aiming to enhance the convenience of hand disinfection.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, dermal sanitizers that allow for direct application to the skin without the need for rinsing have been developed and optimized, aiming to enhance the convenience of hand disinfection. A hand sanitizer is typically characterized as a liquid gel or foam developed to eliminate viruses, germs, and various other microorganisms from the hands [3]. Moreover, it can be categorized into two main types: alcohol-based (ABHS) and alcohol-free hand sanitizer.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Non-Toxic, Antimicrobial, and Alcohol-Free Hand Sanitizer Nanoemulgel Based on Lemon Peel Extract

Ibrahim,

Shalaby,

El-Liethy

et al. 2024

Cosmetics

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Recently, hand sanitization has gained attention for preventing disease transmission. Many on-the-market convenient dermal sanitizers contain alcohol, which can be detrimental to the skin. Therefore, three nanoemulgel formulations (LN-F1, LN-F2, LN-F3) incorporating lemon peel extract (LE), and with various increasing concentrations of xanthan gum as a gelling agent and stabilizer, were developed and characterized as a novel alternative. All formulations showed non-Newtonian shear-thinning flow behavior, particle size values below 200 nm, and increasing zeta potential with higher xanthan gum concentrations. All nanoemulgel formulations exhibited greater in vitro phenolic compound release than free LE. LN-F2 (1.0% LE, 20.0% mineral oil, 20.0% Span 80, 4.0% Cremophor RH 40, 4.0% PEG 400, 0.5% xanthan gum, 50.5% dH2O) was selected as the optimal formulation due to improved characteristics. LE and LN-F2 potential cytotoxicity was assessed on MA-104, showing no significant cellular morphological alterations up to 10 mg/mL for both samples. LN-F2 showed in vitro antimicrobial activity against E. coli, S. Typhimurium, P. aeruginosa, S. aureus, L. monocytogenes, and C. albicans, as well as antiviral activity against phiX 174, but no effect against rotavirus (SA-11). In vivo, LN-F2 presented a removal capacity of 83% to 100% for bacteria and 89% to 100% for fungi. These findings suggest that the formulated nanoemulgel holds potential as a safe and effective antiseptic, providing a viable alternative to commercial alcohol-based formulations.

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“…Access to hand hygiene interventions and waterFive reviewed studies(21)(22)(23)(24)(25)have acknowledged the importance of access to hand hygieneinterventions. A study by Abdullahi et al, (2020) focusing Kenya indicated that access to hand hygiene interventions were effective in reducing the transition of Covid-19…”

mentioning

confidence: 99%

Enablers and Barriers to Handwashing and Vaccine Uptake in Kenya, Uganda, and Tanzania in Relation to COVID-19 Prevention and Control: A Systematic Review

Muchangi,

Mturi,

Mukasa

et al. 2023

Preprint

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Background The Coronavirus disease 2019 has brought about unprecedented challenges globally, threatening to undo the decades of progress on poverty, health systems and education. Several efforts have been put forward to edge the spread of the covid-19 disease including handwashing and mass vaccination. Despite their proven effectiveness, the uptake is low thus threatening to undermine the future successes of vaccination and handwashing campaigns. This review intends to determine the enablers and barriers to handwashing and vaccine uptake in Kenya, Uganda, and Tanzania in relation to COVID-19 prevention and control. Methods This review was carried according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA-P) guidelines. A comprehensive literature search of studies from three databases: PubMed, Direct science and Google Scholar was conducted. Published studies within the period between December 2019 up to end of January 2023 on enablers and barriers on handwashing and vaccine uptake in Kenya, Uganda, and Tanzania in relation to COVID-19 prevention and control were assessed and selected. Results A total of 391 research were reviewed, and 21 studies eligible for inclusion in the review. Results indicate that in the three countries: Kenya, Uganda, and Tanzania; the most cited barriers to handwashing and vaccine uptake include concerns on safety, efficacy, and quality of manufactured vaccines and handwashing practices, lack of awareness, lack of trust to the vaccines and handwashing, myths, misconceptions, and risk-perceptions. Enablers to handwashing and Covid-19 vaccine uptake identified were access to knowledge, access to hand hygiene programmes and water, involvement of community leaders to create awareness and socio-economic factors such as education level and cash incentives. Conclusion The study has identified enablers and barriers that can influence the success of these interventions in Kenya, Uganda, and Tanzania in relation to COVID-19 prevention and control. Stakeholders should formulate strategize to address the identified barriers leveraging on enablers to motivate the individuals to accept vaccination and practice more hand hygiene through creating awareness and sensitization through community leaders, making the vaccines and clean water or soap available and accessible. Registration PROSPERO ID CRD42023396303; registered on 2nd February 2023

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A comparative in-vitro study on antimicrobial efficacy of on-market alcohol-based hand washing sanitizers towards combating microbes and its application in combating Covid-19 global outbreak

Cited by 6 publications

References 36 publications

Sonochemical synthesis of bioinspired graphene oxide–zinc oxide hydrogel for antibacterial painting on biodegradable polylactide film

Sonochemical synthesis of bioinspired graphene oxide–zinc oxide hydrogel for antibacterial painting on biodegradable polylactide film

Formulation and Characterization of Non-Toxic, Antimicrobial, and Alcohol-Free Hand Sanitizer Nanoemulgel Based on Lemon Peel Extract

Enablers and Barriers to Handwashing and Vaccine Uptake in Kenya, Uganda, and Tanzania in Relation to COVID-19 Prevention and Control: A Systematic Review

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