A Comparative Evaluation of Medical Grade Calcium Sulphate Hemihydrate With and Without Platelet Rich Fibrin as a Bone Regenerative Material in the Treatment of Intraosseous Periodontal Defects- A Clinical and CBCT (Cone Beam Computed Tomography) Assessment

Abstract

The periodontal regeneration is one of the main objective in periodontal management and can be achieved by use of barrier membrane, bone grafts and growth factors. Calcium sulphate, an alloplast material and platelet rich fibrin was used in this clinical trial. Aims: To compare medical grade calcium sulphate hemihydrate with and without platelet rich fibrin as a bone regenerative material in the treatment of intraosseous periodontal defects by clinical and CBCT assessment. Materials and Methods: 30 defect sites were included in the study and were randomly allocated to either Group A, Group B or Group C. Group A was the control group, Group B included the placement of medical grade calcium sulphate hemihydrate whereas Group C included the placement of medical grade calcium sulphate hemihydrate with platelet rich fibrin in periodontal intrabony defects. Statistical analysis of plaque index, gingival index, probing pocket depth, clinical attachment loss and defect fill by CBCT was performed. Statistical analysis used: Kruskal Walis test and Chi‑square test for categorical variables were used for analysis. The critical levels of significance of the results were considered at 0.05 levels, i.e., P < 0.05 was considered statistically significant. Results: Statistically more significant difference in probing pocket depth, clinical attachment loss and defect fill was observed in Group C (MGCSH+PRF) in comparison to Group B (Medical Grade Calcium Sulphate Hemihydrate) which showed better results than Group A. Conclusion: MGCSH with PRF produced more favourable results than MGCSH alone.