A comparative evaluation of endodontic treatments for immature necrotic permanent teeth based on clinical and radiographic outcomes: a systematic review and meta‐analysis

Abstract

Although almost all of the identified studies presented moderate risk of bias, MTA apexification seems to produce overall better clinical and radiographic success rates among the endodontic treatment available in immature necrotic permanent teeth.

A prospective clinical study of regenerative endodontic treatment of traumatized immature teeth with necrotic pulps using bi‐antibiotic paste

“…The use of RET has gained popularity with several published case reports/series (Kontakiotis et al 2015), a growing base of randomized controlled trials (Nagata et al 2014, Nagy et al 2014, Bezgin et al 2015, several systematic reviews (Moreno-Hidalgo et al 2013, Kontakiotis et al 2014) and a meta-analysis (Nicoloso et al 2016). Despite agreeing that the success of this technique in achieving regeneration rather than revascularization/repair/mutagenesis is dependent upon achieving four essential tissue engineering principles mainly (i) availability of suitable stem cells, (ii) a scaffold for the stem cells to populate and orient in three dimensional manner, (iii) appropriate signalling molecules promoting stem cell differentiation into the desired odontoblasts and (iv) disinfection of the root canal system without damage to stem cells (Wigler et al 2013, Galler 2015, several RET techniques have been used and reported (Kontakiotis et al 2015).…”

“…Kontakiotis et al 2015), a growing base of randomized controlled trials(Nagata et al 2014, Nagy et al 2014, Bezgin et al 2015, several systematic reviews(Moreno-Hidalgo et al 2013, Kontakiotis et al 2014) and a meta-analysis(Nicoloso et al 2016)…”

The effect of platelet‐rich plasma as a scaffold in regeneration/revitalization endodontics of immature permanent teeth assessed using 2‐dimensional radiographs and cone beam computed tomography: a randomized controlled trial

“…Albeit inconsistent, the ability of this technique to promote root lengthening, thickening of root dentinal walls and apical closure (Table 1; Nicoloso et al . 2016, Tong et al . 2017, Torabinejad et al .…”

A biocompatible decellularized pulp scaffold for regenerative endodontics

“…Dental tissue regeneration has recently emerged as an exciting new concept in managing immature teeth with nonvital pulps (European Society of Endodontology 2016) with several published protocols having variable outcomes (Nicoloso et al 2017). These protocols share common steps involving chemical disinfection, utilization of stem cells of the apical papilla and scaffold creation through induction of a blood clot (Galler 2016).…”