A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations

Dalai, Swayamprava; Pakrashi, Sunandan; Rajendran, Kumar; Chandrasekaran, N.; Mukherjee, Amitava

doi:10.1039/c2tx00012a

Cited by 139 publications

(99 citation statements)

References 68 publications

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“…Further, the SEM images demonstrated clear distortion of the cell membrane on treatment with drug-loaded microemulsion system. This result can be correlated with another study (67), in that, they reported irregular boundary and unclear margins of cell membrane of cariogenic Streptococcus mutans upon treatment with soyabean oil emulsion with very small droplet-sized diameter. But, no considerable morphologic changes were seen in the conventional formulation of azithromycin at the same minimized optimum (4 μg/ml) concentration.…”

Section: Discussionsupporting

confidence: 78%

Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus

2013

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Abstract. Azithromycin, an important member of the azalide subclass is effective against both Grampositive and Gram-negative organisms. Certain physicochemical properties of the drug like poor water solubility and relatively low bioavailability of 37% due to incomplete absorption after ingestion, aroused the need for the development of a novel drug delivery system to enhance the solubilization potential and antibacterial activity against Staphylococcus aureus at a very low concentration. Cinnamon oil (Cinnamonum zeylanicum)-based microemulsion system formulated using non-ionic surfactant, Tween 20, and water was characterized. The drug-incorporated system F4 (oil to surfactant ratio of 1:4 (v/v)) showed enhanced solubilization of the drug, droplet diameter of 5-8 nm, and a good thermodynamic stability. The effect of surfactant concentration exhibited a negative correlation with droplet size diameter and turbidity and a positive correlation with stability and viscosity. The system was investigated for its antibacterial activity that demonstrated a significantly higher activity at a minimum concentration (4 μg/ ml) of the novel drug-loaded system in comparison with the conventional formulation (128 μg/ml). Examination through scanning electron microscopy analysis further confirmed a considerable morphologic variation due to alteration in the membrane permeability of the microemulsion-treated system. The small droplet size of the microemulsion system and the antibacterial property of cinnamon oil, together, accounts clearly for the enhanced efficacy of the new formulated system F4 and not just azithromycin alone. Staining with acridine orange/ethidium bromide dyes as examined through fluorescence microscopy also substantiated with the results of membrane permeability of bacteria. Thus, our study discloses a potential oral drug delivery system of azithromycin with improved biocompatibility.

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Section: Discussionsupporting

confidence: 78%

Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus

2013

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“…Recently, Dalai et al (2012) reported that NP dispersed in lake water was found to show a peak at 336 nm, whereas Hasan et al (2010) measured the maximum absorption wavelength of synthesized TiO 2 NPs at 337 nm. The observed blue-shift is probably due to a decrease of particles size occurring as consequence of long sonication treatment.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity assessment of TiO2 nanoparticles in the teleost Danio rerio

Rocco

Santonastaso

Mottola

et al. 2015

Ecotoxicology and Environmental Safety

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“…TiO 2 0.1 fabric. In addition, the latest studies showed that TiO 2 NPs can interact with bacteria even in the absence of UV light (Dalai et al 2012;Zhukova et al 2012). Radicals generated from TiO 2 NPs in anatase form under non-UV conditions may trigger cytotoxicity (Dalai et al 2012).…”

Section: Biodegradation Behavior Of Co Fabricsmentioning

confidence: 99%

Negative influence of Ag and TiO2 nanoparticles on biodegradation of cotton fabrics

et al. 2015

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Recently, many efforts have been made to efficiently impregnate different textile materials with metal and metal oxide nanoparticles in order to provide antimicrobial, UV protective or self-cleaning properties. Evidence of their environmental risks is limited at this point. The aim of this study was to explore the influence of Ag and TiO 2 nanoparticles on biodegradation of cotton fabrics. Biodegradation behavior of cotton fabrics impregnated with Ag and TiO 2 NPs from colloidal solutions of different concentrations was assessed according to standard test method ASTM 5988-03 and soil burial test.Degradation of cotton fabrics was also evaluated by enzymatic hydrolysis with cellulase. The morphology of fibers affected by biodegradation was analyzed by scanning electron microscopy (SEM). In order to get better insight into biodegradation process, dehydrogenase activity of soil has been determined. Ag and particularly TiO 2 nanoparticles suppressed the biodegradation of cotton fabrics. The dehydrogenase activity of soil with cotton fabrics impregnated with TiO 2 nanoparticles was the weakest. Severe damage of cotton fibers during the biodegradation process was confirmed by SEM.

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A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations

Cited by 139 publications

References 68 publications

Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus

Design and Formulation Technique of a Novel Drug Delivery System for Azithromycin and its Anti-Bacterial Activity Against Staphylococcus aureus

Genotoxicity assessment of TiO2 nanoparticles in the teleost Danio rerio

Negative influence of Ag and TiO2 nanoparticles on biodegradation of cotton fabrics

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