A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms

Shi, Jie; Xu, Guangyang; Liu, Tingting; Wang, Xi; Liyang, Shen; Li, Jing; Hao, Wei; Chen, Hongxian; Li, Suxia; Lü, Lin

doi:10.1080/00952990802491563

Cited by 16 publications

(12 citation statements)

References 14 publications

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“…[53] Two major types of ginseng exist, Panax ginseng (Asian ginseng) and Panax quinquefolium (American ginseng). [62] The investigators found that the herbal mixture was as effective as lofexidine at alleviating the symptoms of opioid withdrawal, with patients reporting only gradual improvement in symptomatology over the study period. [59] Ginsenosides have putative effects on the CNS and cardiovascular system, and may alter metabolism and immune function.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…[58] Ginseng is another botanical commonly used in Chinese traditional remedies. [62] In this double-blind study, 212 heroin addicts were randomized to treatment with either the ginseng herbal mixture or to lofexidine over a 10-day period. The main active natural products in Panax ginseng are called ginsenosides, of which more than 20 have been characterized.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…The main active natural products in Panax ginseng are called ginsenosides, of which more than 20 have been characterized. [62] Unfortunately, lofexadine is minimally effective at treating acute opioid withdrawal, and the study design did not incorporate a placebo arm. [60] Panax ginseng attenuates the physiological effects of drugs of abuse including morphine in pre-clinical studies.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…[59] Ginsenosides have putative effects on the CNS and cardiovascular system, and may alter metabolism and immune function. [62] It is therefore possible that what was observed in the patients was untreated opioid withdrawal, the natural history of which is improvement over time. [61] A multicentre clinical trial found that Radix ginseng (the root of Panax ginseng) was safe and effective for the treatment of moderate-to-severe acute heroin withdrawal.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

“…[60] Panax ginseng attenuates the physiological effects of drugs of abuse including morphine in pre-clinical studies. [62,63] The active chemical in Panax quinquefolium, not found in Panax ginseng, is pseudoginsenoside-F11 (PF11), a saponin. [62] In this double-blind study, 212 heroin addicts were randomized to treatment with either the ginseng herbal mixture or to lofexidine over a 10-day period.…”

Section: Chinese Herbal Remediesmentioning

confidence: 99%

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Herbal Medicines for the Management of Opioid Addiction

et al. 2011

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Striking increases in the abuse of opioids have expanded the need for pharmacotherapeutic interventions. The obstacles that confront effective treatment of opioid addiction - shortage of treatment professionals, stigma associated with treatment and the ability to maintain abstinence - have led to increased interest in alternative treatment strategies among both treatment providers and patients alike. Herbal products for opioid addiction and withdrawal, such as kratom and specific Chinese herbal medications such as WeiniCom, can complement existing treatments. Unfortunately, herbal treatments, while offering some advantages over existing evidence-based pharmacotherapies, have poorly described pharmacokinetics, a lack of supportive data derived from well controlled clinical trials, and severe toxicity, the cause for which remains poorly defined. Herbal products, therefore, require greater additional testing in rigorous clinical trials before they can expect widespread acceptance in the management of opioid addiction.

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Section: Chinese Herbal Remediesmentioning

confidence: 99%

Section: Chinese Herbal Remediesmentioning

confidence: 99%

Section: Chinese Herbal Remediesmentioning

confidence: 99%

Section: Chinese Herbal Remediesmentioning

confidence: 99%

Section: Chinese Herbal Remediesmentioning

confidence: 99%

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Herbal Medicines for the Management of Opioid Addiction

et al. 2011

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Traditional Chinese Medicine (TCM) Therapy

Xiao

Tao

2017

Advances in Experimental Medicine and Biology

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Traditional Chinese Medicine(TCM) has been utilized in China for more than 2,000 years, and it has been practiced in treatment of substance addiction and non-substance addictions. TCM have efficacy in the rehabilitation of abnormal physical problems induced by chronic drug use, including improving immune function, increasing working memory, and protecting against neurological disorders. Given that TCM is potentially effective in the prevention of relapse, it has been suggested that TCM may be the ideal choice in the future for the treatment of opiate addiction. This review examines the significance of effective Chinese herbs and prescriptions for Drug Addiction, Alcohol addiction and food addiction.

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Is It Prime Time for Alpha2-Adrenocepter Agonists in the Treatment of Withdrawal Syndromes?

et al. 2014

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The need to treat withdrawal syndromes is a common occurrence in outpatient, inpatient ward, and intensive care unit (ICU) settings. A PubMed and Google Scholar search using alpha2-adrenoreceptor agonist (A2AA), specific A2AA agents, withdrawal syndrome and nicotine, and alcohol and opioid withdrawal terms was performed. A2AA agents appear to be able to modulate many of the signs and symptoms of significant withdrawal syndromes but are also capable of significant side effects, which can limit clinical use. Non-opioid oral A2AA agent use for opioid withdrawal has been well established. Pharmacologic combination therapy that utilizes A2AA agents for withdrawal syndromes appears promising but requires further formal testing to better define which other agents, under what condition(s), and at what A2AA doses are needed. The A2AA dexmedetomidine may be useful as an adjunctive agent in treating severe alcohol withdrawal syndromes in the ICU. In general, the current data does not support the routine use of A2AA as the primary or sole agent to treat ethanol/alcohol or nicotine withdrawal syndromes. Specific A2AA agents such as lofexidine has been shown to have a primary role in non-opioid-based treatment of opioid withdrawal syndrome and dexmedetomidine in combination with benzodiazepines has been shown to have potential in the treatment of severe ICU-based alcohol withdrawal syndrome.

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A Comparative Clinical Study of the Effects of the Traditional Chinese Medicine Jinniu Capsules and Lofexidine on Acute Heroin Withdrawal Symptoms

Abstract: Jinniu capsules may be an effective and safe agent in the management of opiate withdrawal.

Cited by 16 publications

References 14 publications

Herbal Medicines for the Management of Opioid Addiction

Herbal Medicines for the Management of Opioid Addiction

Traditional Chinese Medicine (TCM) Therapy

Is It Prime Time for Alpha2-Adrenocepter Agonists in the Treatment of Withdrawal Syndromes?

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