A comparative approach of MIR, NIR and Raman based chemometric strategies for quantification of Form I of Meloxicam in commercial bulk drug

Antonio, Marina; Carneiro, Renato Lajarim; Maggio, Rubén M.

doi:10.1016/j.microc.2022.107575

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…FT-Raman spectra of pure meloxicam, tartaric acid and their equimolar mixture are given in Figure 6. The Form I polymorph of meloxicam, the most stable one among the five known polymorphs, is emphasized with FT-Raman spectroscopy using the vibrational modes of C=O, C=C (1600-1400) cm −1 , C-C (1300-1200) cm −1 and C-S (1200-800) cm −1 stretching [31,34,35]. Tartaric acid peaks are identified at 2968, 2934, 1739, 1693 and 1257 cm −1 [36].…”

Section: Ftir and Ft-raman Studymentioning

confidence: 99%

Binary Mixtures of Meloxicam and L-Tartaric Acid for Oral Bioavailability Modulation of Pharmaceutical Dosage Forms

Macasoi,

Meltzer,

Stanculescu

et al. 2024

JFB

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Binary mixtures of active pharmaceutical ingredients (API) are researched to improve the oral bioavailability of pharmaceutical dosage forms. The purpose of this study was to obtain mixtures of meloxicam and L-tartaric acid because tartaric acid improves intestinal absorption and meloxicam is more soluble in a weakly basic environment. The mixtures in the 0–1 molar fraction range, obtained from solvent-assisted mechanosynthesis, were investigated by differential scanning calorimetry (DSC), Fourier Transform Infrared (FTIR) spectroscopy, Fourier Transform Raman spectroscopy (FT-Raman), X-ray powder diffraction (XRD) and solubility tests. The physicochemical characteristics of the compounds obtained from DSC data reveal, for the first time, the formation of a co-crystal at meloxicam molar fraction of 0.5. FTIR spectroscopy data show the existence of hydrogen bonds between the co-crystal components meloxicam and L-tartaric acid. FT-Raman spectroscopy was used complementary with FT-IR spectroscopy to analyze the pure APIs and their mixtures, to emphasize the appearance/disappearance and the shifts of the position/intensity of vibrational bands, following the formation of hydrogen-bonded structures or van der Waals interactions, and to especially monitor the crystal lattice vibrations below 400 cm−1. The experimental results obtained by X-ray powder diffraction confirmed the formation of the co-crystal by the loss and, respectively, the apparition of peaks from the single components in the co-crystal diffractogram. The solubility tests showed that the co-crystal product has a lower aqueous solubility due to the acidic character of the other component, tartaric acid. However, when the solubility tests were performed in buffer solution of pH 7.4, the solubility of meloxicam from the co-crystal mixture was increased by 57% compared to that of pure meloxicam. In conclusion, the studied API mixtures may be considered potential biomaterials for improved drug release molecular solids.

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