A comparative analysis of thermal ablation techniques in the treatment of primary and secondary lung tumors: a single-center experience

Grasso, Rosario Francesco; Bernetti, Caterina; Santucci, Domiziana; Altomare, Carlo; Castiello, Gennaro; Andresciani, Flavio; Sarli, Marina; Zobel, Bruno Beomonte; Faiella, Eliodoro

doi:10.1007/s11547-022-01508-2

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…A meta-analysis has confirmed that there is no significant difference in the incidence of pneumothorax between RFA and MWA in the treatment of CRLM 30 . Additionally, a recent comparative study has also yielded similar results 6 . Ablation type was not included in the final model generated in this study; however, it did have an impact on the marginal effect of the number of tumour ablations on pneumothorax.…”

Section: Discussionmentioning

confidence: 56%

“…The 3-year OS rate achieved by IGTA in the treatment of CRLM within 3 cm size reached an impressive 84% 3 , positioning it as a viable alternative to pneumoresection 4 , 5 . While IGTA is generally considered safe and reproducible, with minor damage to lung structure and reserve function, the presence of associated complications, especially pneumothorax, poses a significant limitation to the technique 6 .…”

Section: Introductionmentioning

confidence: 99%

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Risk assessment of pneumothorax in colorectal lung metastases treated by percutaneous thermal ablation: a multicenter retrospective cohort study

Fan,

Xie,

Pang

et al. 2023

International Journal of Surgery

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Purpose: To evaluate the risk of pneumothorax in the percutaneous image-guided thermal ablation (IGTA) treatment of colorectal lung metastases (CRLM). Methods: Data regarding patients with CRLM treated with IGTA from five medical institutions in China from 2016 to 2023 were reviewed retrospectively. Pneumothorax and non-pneumothorax were compared using the Student’s t test、Chi-square test and Fisher’s exact test. Univariate logistic regression analysis was conducted to identify potential risk factors, followed by multivariate logistic regression (MLR) analysis to evaluate the predictors of pneumothorax. Interactions between variables were examined and used for model construction. Receiver operating characteristic (ROC) curves and nomograms were generated to assess the performance of the model. Results: A total of 254 patients with 376 CRLM underwent 299 ablation sessions. The incidence of pneumothorax was 45.5%. The adjusted MLR model, incorporating interaction terms, revealed that tumor number (odds ratio [OR]=8.34 [95% confidence interval [CI]: 1.37-50.64]), puncture depth (OR=0.53 [95%CI: 0.31-0.91]), pre-procedure radiotherapy (OR=3.66 [95%CI: 1.17-11.40]), peri-bronchial tumor (OR=2.32 [95%CI: 1.04-5.15]), and emphysema (OR=56.83 [95%CI: 8.42-383.57]) were significant predictive factors of pneumothorax (all P<0.05). The generated nomogram model demonstrated a significant prediction performance, with an area under the ROC curve of 0.800 (95%CI: 0.751-0.850). Conclusions: Pre-procedure radiotherapy, tumor number, peri-bronchial tumor, and emphysema were identified as risk factors for pneumothorax in the treatment of CRLM using percutaneous IGTA. Puncture depth was found to be a protective factor against pneumothorax.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Risk assessment of pneumothorax in colorectal lung metastases treated by percutaneous thermal ablation: a multicenter retrospective cohort study

Fan,

Xie,

Pang

et al. 2023

International Journal of Surgery

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“…A wide range of therapeutic options has been developed for treatment of primary and secondary liver tumors to compensate for the limited effectiveness of systemic therapies [54][55][56][57][58][59][60][61][62][63][64][65].…”

Section: Discussionmentioning

confidence: 99%

Percutanous Electrochemotherapy (ECT) in Primary and Secondary Liver Malignancies: A Systematic Review

Granata

Fusco²,

D'Alessio³

et al. 2023

Diagnostics

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The aim of the study was to analyse papers describing the use of Electrochemotherapy (ECT) in local treatment of primary and secondary liver tumours located at different sites and with different histologies. Other Local Ablative Therapies (LAT) are also discussed. Analyses of these papers demonstrate that ECT use is safe and effective in lesions of large size, independently of the histology of the treated lesions. ECT performed better than other thermal ablation techniques in lesions > 6 cm in size and can be safely used to treat lesions distant, close, or adjacent to vital structures. ECT spares vessel and bile ducts, is repeatable, and can be performed between chemotherapeutic cycles. ECT can fill the gap in local ablative therapies due to being lesions too large or localized in highly challenging anatomical sites.

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“…Treatment options for LM may include local therapies, such as thermal ablation techniques and stereotactic ablative body radiation [ 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ], chemotherapy [ 97 , 98 ] and, in selected cases, surgery [ 99 , 100 , 101 ]. The introduction of new systemic treatments, including immunotherapy and target therapies, has improved the prognosis of patients with metastatic tumors, but only a subset of mutated patients can benefit from such treatments [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

Radiomics in Lung Metastases: A Systematic Review

Gabelloni

Faggioni

Fusco

et al. 2023

JPM

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Due to the rich vascularization and lymphatic drainage of the pulmonary tissue, lung metastases (LM) are not uncommon in patients with cancer. Radiomics is an active research field aimed at the extraction of quantitative data from diagnostic images, which can serve as useful imaging biomarkers for a more effective, personalized patient care. Our purpose is to illustrate the current applications, strengths and weaknesses of radiomics for lesion characterization, treatment planning and prognostic assessment in patients with LM, based on a systematic review of the literature.

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A comparative analysis of thermal ablation techniques in the treatment of primary and secondary lung tumors: a single-center experience

Cited by 6 publications

References 30 publications

Risk assessment of pneumothorax in colorectal lung metastases treated by percutaneous thermal ablation: a multicenter retrospective cohort study

Risk assessment of pneumothorax in colorectal lung metastases treated by percutaneous thermal ablation: a multicenter retrospective cohort study

Percutanous Electrochemotherapy (ECT) in Primary and Secondary Liver Malignancies: A Systematic Review

Radiomics in Lung Metastases: A Systematic Review

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