A comparative analysis of the distribution of glyprolines after their administration by different ways

Ашмарин, И. П.; Baglikova, K. E.; Edeeva, S. E.; Zolotarev, Yu. A.; Kozik, V. S.; Dadayan, A. K.; Dorokhova, E. M.; Alfeeva, L. Yu.; Andreeva, L. A.; Kopylova, G. N.; Pavlov, Tengis S.; Vaskovsky, B. V.; Meshavkin, V. K.; Sokolov, O. Yu.; Кост, Н. В.; Zozulya, A. A.; Samonina, G. E.; Myasoedov, N. F.

doi:10.1134/s1068162008040043

Cited by 4 publications

(4 citation statements)

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“…The neurotropic effects of this dipeptide on stressed animals are no less pronounced than the effects of PGP [5]. GP is the main metabolite of Selanc, a synthetic peptide anxiolytic [1]. We also observed a depriming effect of Selanc in verticalization test, but this peptide did not modify 3 H-spiperone binding to D 2 receptors in vitro [7].…”

Section: Resultsmentioning

confidence: 90%

“…It enters unchanged into the circulation and crosses the blood-brain barrier [3]. However, just one thousandth of the injected peptide reaches the brain and is gradually hydrolyzed with the formation of GP as the main metabolite [1]. The neurotropic effects of this dipeptide on stressed animals are no less pronounced than the effects of PGP [5].…”

Section: Resultsmentioning

confidence: 99%

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Effects of Pro-Gly-Pro Tripeptide on the Dopamine System

et al. 2011

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Effects of Pro-Gly-Pro Tripeptide on the Dopamine System

et al. 2011

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“…We studied the effects of Selank and GABA on changes in the mRNA levels of 84 genes involved in neurotransmission in the frontal cortex of rats 1 and 3 h after the intranasal administration of the compounds. The intranasal administration of Selank was shown to be optimal for delivery of peptide molecules in the CNS (Zolotarev et al, 2006 ; Ashmarin et al, 2008 ).…”

Section: Resultsmentioning

confidence: 99%

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

et al. 2016

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Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To test this hypothesis we studied the effect of Selank and GABA on the expression of genes involved in neurotransmission. We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method. We found significant changes in the expression of 45 genes 1 h after the administration of the compounds. Three hours after Selank or GABA administration, 22 genes changed their expression. We found positive correlation between the changes in genes expression within 1 h after administration of Selank or GABA. Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission. The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.

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“…Selank dose of 300 μ g/kg was selected based on the data that this dose was the most effective therapy dose exerting anxiolytic action [ 10 , 13 ]. The intranasal administration of Selank was shown to be optimal for the delivery of peptide molecules in the CNS [ 14 , 15 ].…”

Section: Methodsmentioning

confidence: 99%

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

Kasian

Kolomin

Andreeva

et al. 2017

Behavioural Neurology

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It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.

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A comparative analysis of the distribution of glyprolines after their administration by different ways

Cited by 4 publications

References 6 publications

Effects of Pro-Gly-Pro Tripeptide on the Dopamine System

Effects of Pro-Gly-Pro Tripeptide on the Dopamine System

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

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