A Comparative Analysis of the Medicinal Plants Used for Diabetes Mellitus in the Traditional Medicine in Turkey, Pakistan, and Malaysia

Öztürk, Münir; Altay, Volkan; Latiff, A.; Ziaee, Muhammad Asad; Choudhry, M. Iqbal; Shaheen, Farzana; Durmuşkahya, Cenk

doi:10.1007/978-3-319-93997-1_11

Cited by 33 publications

(7 citation statements)

References 126 publications

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“…Diabetes mellitus (DM) morbidity and mortality have become serious worldwide health concerns in both developed and developing nations ( 14 , 15 ) straining the world economy ( 16 ). Recent controversial claims argue that the disease burden has shifted to developing countries, exacerbating the problem ( 17 , 18 ) because developing countries already house 79 percent of the world’s diabetes population ( 19 ), and the majority comprises of young people belonging to the lowest socioeconomic strata ( 20 ).…”

Section: The Rising Prevalence Of Diabetes Mellitus and The Need For ...mentioning

confidence: 99%

“…“Extra-nutritional” variables, such as the usage of bisphenol A (BPA) in food processing and packaging, also contribute to the spread of diabetes and accompanying comorbidities ( 24 ). Societies that have recently transitioned to modern lifestyles have been particularly hard hit by T2DM ( 14 ). Asians appear more vulnerable to T2DM, including those in Pakistan, where its incidence has exceeded projections ( 25 ).…”

Section: The Rising Prevalence Of Diabetes Mellitus and The Need For ...mentioning

confidence: 99%

“…Additionally, a whopping 374 million are estimated to be prediabetic, a physiological state that usually leads to full-blown T2DM, a number that is projected to climb by an additional 200 million in the next decades ( 28 ). Due to their inadequate healthcare infrastructure, developing nations such as Pakistan will be the hardest hit by these dismal projections ( 25 ); thus, traditional medicine will assume even greater importance for the general population in the coming years ( 14 , 29 ).…”

Section: The Rising Prevalence Of Diabetes Mellitus and The Need For ...mentioning

confidence: 99%

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Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Shaukat,

Zaidi,

Anwar

et al. 2023

Front. Nutr.

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IntroductionLong used in traditional medicine, Nigella sativa (NS; Ranunculaceae) has shown significant efficacy as an adjuvant therapy for diabetes mellitus (DM) management by improving glucose tolerance, decreasing hepatic gluconeogenesis, normalizing blood sugar and lipid imbalance, and stimulating insulin secretion from pancreatic cells. In this review, the pharmacological and pharmacokinetic properties of NS as a herbal diabetes medication are examined in depth, demonstrating how it counteracts oxidative stress and the onset and progression of DM.MethodsThis literature review drew on databases such as Google Scholar and PubMed and various gray literature sources using search terms like the etiology of diabetes, conventional versus herbal therapy, subclinical pharmacology, pharmacokinetics, physiology, behavior, and clinical outcomes.ResultsThe efficiency and safety of NS in diabetes, notably its thymoquinone (TQ) rich volatile oil, have drawn great attention from researchers in recent years; the specific therapeutic dose has eluded determination so far. TQ has anti-diabetic, anti-inflammatory, antioxidant, and immunomodulatory properties but has not proved druggable. DM’s intimate link with oxidative stress, makes NS therapy relevant since it is a potent antioxidant that energizes the cell’s endogenous arsenal of antioxidant enzymes. NS attenuates insulin resistance, enhances insulin signaling, suppresses cyclooxygenase-2, upregulates insulin-like growth factor-1, and prevents endothelial dysfunction in DM.ConclusionThe interaction of NS with mainstream drugs, gut microbiota, and probiotics opens new possibilities for innovative therapies. Despite its strong potential to treat DM, NS and TQ must be examined in more inclusive clinical studies targeting underrepresented patient populations.

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Section: The Rising Prevalence Of Diabetes Mellitus and The Need For ...mentioning

confidence: 99%

Section: The Rising Prevalence Of Diabetes Mellitus and The Need For ...mentioning

confidence: 99%

Section: The Rising Prevalence Of Diabetes Mellitus and The Need For ...mentioning

confidence: 99%

See 1 more Smart Citation

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Shaukat,

Zaidi,

Anwar

et al. 2023

Front. Nutr.

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“…Diabetes is one of the physiological disorders that effects human activities and can damage various body parts [29]. Different species of Caralluma have been reported to cure diabetes.…”

Section: Diabeticsmentioning

confidence: 99%

Effect of aerial part and root extracts from Ferula orientalis L. growing in Turkey on erectile dysfunction in streptozotocin-ınduced diabetic rats

Karakaya¹,

Oral²,

Gür³

et al. 2019

BioDiCon

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Caralluma tuberculata N.E. Brown is a perennial herb. It belongs to Asclepiadaceae family, mostly found in the mountainous regions of Pakistan. The plant is used as vegetable in cooked form, consumed as tea or used in the dry powder form or chewed fresh. It is of great medicinal importance. Many communities have used this plant -as folk medicine for years to cure various ailments such as stomach problems, diabetes, muscle pain and skin treatment and as appetizer. Modern research suggests that it can be used in the formulation of various drugs. The plant has been tested for its anticancer, anti-diabetic, antioxidant, antimicrobial activities and other ailments. The plant must be conserved for its health benefits. An effort is made here to briefly describe the medicinal value of this important plant and create awareness in the community regarding its conservation.

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“…The genus Centaurea is known for possessing sesquiterpene lactones (SLs) [ 56 , 57 ] and phenolic compounds [ 58 ]. Herein, focusing on the hypoglycemic activity of various species of Centaurea in both folk and modern medicine [ 59 – 66 ], we reviewed different reports on their antidiabetic potency to develop herbal drugs and supplements for controlling blood sugar.…”

Section: Introductionmentioning

confidence: 99%

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Diabetes mellitus (DM) is a long-life metabolic disorder, characterized by high blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve injury and vascular damage. Among different types of diabetes, type 2 is more common and has spread all over the world. Although various therapeutic approaches have been developed to control type 2 DM, regulating blood glucose levels has still remained a controversial challenge for patients. Also, most prescription drugs cause different side effects, such as gastrointestinal disorders. Thus, developing novel and efficient antidiabetic agents possessing fewer adverse effects is in high demand. Method. The literature was comprehensively surveyed via search engines such as Google Scholar, PubMed, and Scopus using appropriate keywords. Results. Medicinal plants, both extracts and isolated active components, have played a significant role in controlling the blood glucose levels. Good-to-excellent results documented in the literature have made them a precious origin for developing and designing drugs and supplements against DM. Centaurea spp. have been traditionally used for controlling high blood glucose levels. Also, the antidiabetic properties of different species of Centaurea have been confirmed in recent studies through in vitro assays as well as in vivo experiments. Conclusion. Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.

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A Comparative Analysis of the Medicinal Plants Used for Diabetes Mellitus in the Traditional Medicine in Turkey, Pakistan, and Malaysia

Cited by 33 publications

References 126 publications

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review

Effect of aerial part and root extracts from Ferula orientalis L. growing in Turkey on erectile dysfunction in streptozotocin-ınduced diabetic rats

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

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