A comparative analysis of mutual information methods for pairwise relationship detection in metagenomic data
Dallace Francis,
Fengzhu Sun
Abstract:Background
Construction of co-occurrence networks in metagenomic data often employs correlation to infer pairwise relationships between microbes. However, biological systems are complex and often display qualities non-linear in nature. Therefore, the reliance on correlation alone may overlook important relationships and fail to capture the full breadth of intricacies presented in underlying interaction networks. It is of interest to incorporate metrics that are not only robust in detecting linear … Show more
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