A comparative analysis of major clinical outcomes using drug‐eluting stents versus bare‐metal stents in a large consecutive patient cohort

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of a biodegradable polymer Cobalt‐Chromium sirolimus‐eluting stent (EXCEL2) in treating de novo coronary artery disease: A pooled analysis of the CREDIT II and CREDIT III trials

Wang

et al. 2017

“…A cohort of 148 consecutive patients with a diagnosis of 3V/LMCAD who were subsequently treated by PCI was assembled from the Rabin Medical Center PCI Database .…”

Section: Methodsmentioning

confidence: 99%

The incremental impact of residual SYNTAX score on long‐term clinical outcomes in patients with multivessel coronary artery disease treated by percutaneous coronary interventions

Witberg

Lavi

Assali

et al. 2015

Self Cite

Objective: To broaden the data supporting the use of the residual SYNTAX score (rSS) to define "reasonable" incomplete coronary revascularization (ICR) in order to improve the allocation of patients with severe coronary artery disease (CAD) to surgical/percutaneous revascularization and long-term clinical outcomes. Introduction: ICR is associated with a worse prognosis in patients with severe CAD, yet no consensus exists regarding its definition. Methods: We studied 148 consecutive patients with triple vessel/left main (3VD/LM) CVD treated by percutaneous coronary interventions (PCI). Clinical outcomes at 3 years were collected; the SS and rSS were calculated. We used various definitions of "reasonable" ICR:no post-PCI total occlusion, single vs. mutivessel residual post-PCI disease, and the rSS at a cutoff value determined according to ROC curve fitted for 3 years major adverse cardiovascular and cerebrovascular adverse events (MACCE) in order to determine which definition has the strongest correlation with long-term outcomes. Results: rSS 8 was associated with significant reductions in 3 year MACCE (19.4 vs. 51.1%, HR 5 3.62, P 5 0.014) Death/MI/ CVA (13.7 vs. 28.8%, HR 5 6.01, P 5 0.030) and repeat revascularization (8.6 vs. 28.9%, HR 5 3.44, P 5 0.033) using a Cox proportional hazard ratio model adjusted to baseline characteristics, whereas single vessel residual disease and absence of total occlusion were not. Conclusions: "Reasonable" ICR as determined by rSS carries better long-term prognosis in terms of clinical outcomes vs. more extensive residual coronary disease in patients with 3VD/LM coronary artery disease treated by PCI. The rSS may improve the allocation of coronary patients to the optimal mode of revascularization. V C 2015 Wiley Periodicals, Inc.

“…Drug‐eluting stents (DES) are superior to bare metal stents (BMS) in restenosis prevention ; however, their safety as assessed mainly by the incidence of stent thrombosis (ST) remains a concern . Consequently, newer DES strive to improve vascular healing while inhibiting the physiological repair processes that are common to any foreign implant .…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of a novel abluminal groove‐filled biodegradable polymer sirolimus‐eluting stent for the treatment of de novo coronary lesions: Two‐year results from a prospective patient‐level pooled analysis of TARGET trials

Gao

Zhang

et al. 2015