A comparative analysis of four protocols for maximal treadmill stress testing

Pollock, Michael L.; Bohannon, R. L.; Cooper, Kenneth H.; Ayres, John J. B.; Ward, Ann; White, Steve R.; Linnerud, A. C.

doi:10.1016/s0002-8703(76)80401-2

Cited by 473 publications

(283 citation statements)

References 11 publications

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“…Duration of this treadmill test is highly correlated with measured maximal oxygen uptake in men (rϭ0.92) and women (rϭ0.94). 31,32 Maximal MET levels of cardiorespiratory fitness (1 METϭ3.5 mL O 2 · kg Ϫ1 · min Ϫ1 ) were estimated from the final treadmill speed and grade. 33 Sexspecific distributions of treadmill exercise duration were formed within the following age groups: 20 to 39, 40 to 49, 50 to 59, and Ն60 years.…”

Section: Methodsmentioning

confidence: 99%

Cardiorespiratory Fitness Is Inversely Associated With the Incidence of Metabolic Syndrome. A Prospective Study of Men and Women

LaMonte¹,

Barlow²,

Jurca³

et al. 2005

ACC Current Journal Review

103

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Section: Methodsmentioning

confidence: 99%

Cardiorespiratory Fitness Is Inversely Associated With the Incidence of Metabolic Syndrome. A Prospective Study of Men and Women

LaMonte¹,

Barlow²,

Jurca³

et al. 2005

ACC Current Journal Review

103

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“…Maximal time on treadmill has been found to correlate highly with measured maximal oxygen uptake in males [16]. Metabolic equivalent (MET) levels were determined from end of test treadmill speed and grade to allow for comparison between patients.…”

Section: Mortality Surveillancementioning

confidence: 99%

Addition of Cardiorespiratory Fitness Within an Obesity Risk Classification Model Identifies Men at Increased Risk of All-Cause Mortality

Ricketts

Sui

Lavie

et al. 2016

The American Journal of Medicine

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“…17,20 Time-to-completion on the treadmill was used to estimate maximal metabolic equivalents (METs) using the following formula: METsϭ[1.44ϫ(minutes on treadmill)ϩ14.99]/3.5. 21 Resting blood pressure was auscultated as the first and fifth Korotkoff sounds according to a standard sphygmomanometer protocol. 22 Stature and body mass were measured using standardized protocols, and body mass index (BMI) was calculated by dividing body mass (kilograms) by stature squared (meters squared) in both studies.…”

Section: Phenotype Measurementsmentioning

confidence: 99%

Effect of Endothelin 1 Genotype on Blood Pressure Is Dependent on Physical Activity or Fitness Levels

et al. 2007

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Abstract-Contributions of the DNA sequence variation at the endothelin 1 locus to the risk of hypertension and to endurance training-induced changes in blood pressure were investigated in the Aerobics Center Longitudinal Study and the Health, Risk Factors, Exercise Training and Genetics Family Study cohorts. We identified 586 normotensive control subjects and 607 incident hypertensive case subjects from the Aerobics Center Longitudinal Study cohort (all whites) who were normotensive and healthy at their first clinic visit. The case subjects were diagnosed with hypertension during an average follow-up of 9.5 years, whereas the control subjects remained normotensive. The allele and genotype frequencies of 5 endothelin 1 haplotype tagging single nucleotide polymorphisms did not differ significantly between the case and control subjects. However, we observed a significant (Pϭ0.0025) interaction between the endothelin 1 rs5370 (G/T; Lys198Asn) genotype and cardiorespiratory fitness level on the risk of hypertension: among low-fit subjects, the rs5370 minor allele (T; 198Asn) was associated with higher risk of hypertension (odds ratio: 1.95; 95% CI: 1.36 to 2.81; Pϭ0.0003), whereas the risk did not differ among genotypes in high-fit subjects. In the white Health, Risk Factors, Exercise Training and Genetics subjects (Nϭ480), the rs5370 T allele was associated with blunted systolic blood pressure (Pϭ0.0046) and pulse pressure (Pϭ0.0016) responses to a 20-week endurance training program. The Lys198Asn variant of the endothelin 1 locus is associated with blood pressure phenotypes in whites. However, the expression of the genotype effect is modulated by physical activity or cardiorespiratory fitness level. Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype.

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A comparative analysis of four protocols for maximal treadmill stress testing

Cited by 473 publications

References 11 publications

Cardiorespiratory Fitness Is Inversely Associated With the Incidence of Metabolic Syndrome. A Prospective Study of Men and Women

Cardiorespiratory Fitness Is Inversely Associated With the Incidence of Metabolic Syndrome. A Prospective Study of Men and Women

Addition of Cardiorespiratory Fitness Within an Obesity Risk Classification Model Identifies Men at Increased Risk of All-Cause Mortality

Effect of Endothelin 1 Genotype on Blood Pressure Is Dependent on Physical Activity or Fitness Levels

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