“…The most recently published studies consider bone as an inhomogeneous material and derive its mechanical properties from the CT dataset, averaging the CT scalar field over each element volume using various algorithms (Huiskes et al, 1998;Keaveny and Bartel, 1993;Perillo-Marcone et al, 2003;. Until quite recently the majority of studies described bone as a homogeneous two phase material, deriving the mechanical properties of cortical and spongious bone from the literature (Spears et al, 2001;Verdonschot et al, 1993;Villarraga et al, 1999), a simplistic approach that has not been still completely abandoned (Cegonino et al, 2004). It is true that the adoption of an inhomogeneous model, often characterized by dozens, if not hundreds, of different material properties, may induce a large computational effort, particularly when performing non-linear simulations.…”