A comparative analysis of conventional and SurePath liquid-based cervicovaginal cytology: A study of 140 cases

Sharma, Jyotsna; Toi, Pampa Ch; Siddaraju, Neelaiah; Sundareshan, Malliga; Habeebullah, Syed

doi:10.4103/0970-9371.182525

Cited by 16 publications

(1 citation statement)

References 16 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common clinical presentation of discharge PV (46%) was comparable with the studies by Garg and Sherwani ( Table-5). The time taken to screen the entire CPS slide was more compared to the same in a LBC slide and the results were comparable with other studies like Sharma J [30] and Singh VB [28] that also have shown LBC to be superior to CPS in time consumed for screening ( Table-6). [32] 3.31 1.26 Nishio H 2018 [33] 0.3 0 Costa MOLP 2015 [34] 4.4 1.7 Present study 5% 3% The percentage of slides that showed inflammation is 77% in CPS and 72% in LBC.…”

Section: Original Research Articlesupporting

confidence: 85%

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Sankar

Selvi

Lenin

et al. 2019

Trop J Pathol Microbiol

View full text Add to dashboard Cite

Introduction: Cervical cancer is the second most common cancer among Indian women and the fourth most frequent cancer in women across the globe. Though effective screening programmes are available, its role in effective prevention in a developing country like ours still remains an unanswered question and the probable reason behind this could be the difficulty in adopting liquid-based cytology (LBC) as the main screening program ahead of conventional pap smear (CPS). Aims and Objectives: This study was performed with an objective to analyse and interpret the samples by both CPS and LBC and to compare the both so as to find out the possibility of implementing LBC in a rural teaching institute of Tamilnadu like ours. Materials and methods: This was a prospective observational study which includes sample of 100 women who have attended the gynaecological outpatient department (OPD) of Vinayaka Missions Kirupananda, Variyar Medical College and Hospitals, Salem, Tamil Nadu. The slides were interpreted by two independent cytopathologists based on The Bethesda System and the results were analysed statistically. Results: The youngest patient was 19 years and the oldest was 68 years old. The most common age group in the study is 4 th decade. The commonest clinical presentation was discharge per vaginum (PV). Screening time was less with LBC which also showed cleaner background compared to CPS. Other parameters like organisms and epithelial cell abnormalities were detected in both CPS and LBC. Conclusion: Even though LBC was few steps above CPS while considering the smear background and time taken to screen the slides, CPS still remains the better among the two in our setup taking into consideration the cost efficacy it provides which is the main factor for the population in our rural setup.

show abstract

Section: Original Research Articlesupporting

confidence: 85%

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Sankar

Selvi

Lenin

et al. 2019

Trop J Pathol Microbiol

View full text Add to dashboard Cite

show abstract

Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic

Paboriboune

Phongsavan

Arounlangsy³

et al. 2022

Cancer Medicine

View full text Add to dashboard Cite

show abstract

Follow‐up with histopathology and HPV testing on LSIL cytology in China’s largest academic woman’s hospital

Tao

Zhang

et al. 2019

Cancer Cytopathology

View full text Add to dashboard Cite

Background Cervical cancer remains a major health problem in China. To provide baseline data for establishing the appropriate screening strategy, the authors investigated the histopathologic follow‐up and human papillomavirus (HPV) testing results of low‐grade squamous intraepithelial lesion (LSIL) cytology in the Chinese Largest Women Hospital. Methods Women with LSIL cytology, human papillomavirus (HPV) testing, and immediate histopathologic follow‐up between 2011 and 2016 were analyzed. Results The frequency of LSIL among 1,095,022 Papanicolaou (Pap) tests was 1.4%, and was significantly higher in cases using liquid‐based cytology (LBC; 1.5%‐1.6%) compared with conventional Pap smears (CPS; 0.5%). The CPS method had performance for predicting cervical intraepithelial neoplasia (CIN) that was comparable to that of LBC (75% vs 69.1% and 71.9%). Among 8079 LSIL cases with an immediate histopathologic diagnosis, CIN‐2/3 or higher (CIN‐2/3+) was found in 11.9% of cases and carcinoma in 0.3% of cases. A total of 158 patients (15.7%) with HPV‐positive LSIL had a diagnosis of CIN‐2/3 compared with 18 patients (5.5%) with HPV‐negative LSIL. In postmenopausal women with LSIL cytology, the detection rate for CIN‐2/3 in HPV‐negative patients was significant lower than that in HPV‐positive patients. Furthermore, HPV type 16 (HPV‐16) was the most common genotype noted in patients with CIN‐2+ lesions, whereas HPV‐18 was the most common in patients with CIN‐1. Conclusions Although its reporting rate is lower than that of LBC, CPS is useful due to its low cost and comparable predictive value. HPV testing is helpful for stratifying postmenopausal women with LSIL into lower and higher risk groups. HPV‐16 is the most commonly identified genotype in CIN‐2+ lesions diagnosed in Chinese women with LSIL cytology, whereas HPV‐18 is the most commonly identified genotype in patients with CIN‐1 lesions.

show abstract

A comparative analysis of conventional and SurePath liquid-based cervicovaginal cytology: A study of 140 cases

Cited by 16 publications

References 16 publications

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Efficacy of careHPV™ human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV‐1 in Lao People's Democratic Republic

Follow‐up with histopathology and HPV testing on LSIL cytology in China’s largest academic woman’s hospital

Contact Info

Product

Resources

About