A Comparative Analysis by SAGE of Gene Expression Profiles of Barrett’s Esophagus, Normal Squamous Esophagus, and Gastric Cardia

Baal, Jantine W. P. M. van; Milano, Francesca; Rygiel, Agnieszka Magdalena; Bergman, Jacques J.G.H.M.; Rosmolen, Wilda D.; Deventer, S. J. H. Van; Wang, Kenneth K.; Peppelenbosch, Maikel P.; Krishnadath, Kausilia K.

doi:10.1053/j.gastro.2005.07.026

Cited by 78 publications

(73 citation statements)

References 37 publications

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“…Our results from head and neck and esophageal squamous cell carcinomas agree with previous findings. 30,40,41 In addition to these results, the immunohistochemical analysis of BMP4 protein expression in tumor samples has only been performed in colorectal, ovarian, gastric, renal and hepatocellular carcinomas as well as in a few samples of melanoma. In colorectal and gastric cancers, BMP4 expression had been identified in the majority of the samples, but strong expression was detected only in a minority, which resembled the staining pattern we also detected.…”

Section: Discussionmentioning

confidence: 99%

“…However, in a previous comparison of adjacent normal and tumor tissues from the stomach, liver and esophagus, BMP4 expression was higher in the tumor samples. 28,40,47 Notably, our normal and tumor tissue microarrays were truly independent samples and not paired unlike previous studies. In the case of four normal tissues (ie, colon, pancreas, thyroid and ovaries) where no BMP4 expression was detected, a subset of the corresponding tumor samples had strong granular BMP4 staining indicating increased BMP4 expression.…”

Section: Discussionmentioning

confidence: 99%

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Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development

Alarmo¹,

Huhtala

Korhonen

et al. 2013

Modern Pathology

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Bone morphogenetic proteins (BMPs) are extracellular signaling molecules that belong to the transforming growth factor b (TGFb) superfamily and are known to regulate cell proliferation, differentiation and motility, especially during development. BMP4 has an indispensable role in vertebrate development while limited information on BMP4 expression and function exists in adult tissues. Nevertheless, its contribution to cancer development and progression has gained increasing interest in recent years. Functional studies, especially in breast cancer, have implicated BMP4 both in inhibition of cell proliferation and in promotion of cell migration and invasion. To gain an insight into the function of BMP4 in normal and cancer tissues, BMP4 protein expression levels were analyzed by immunohistochemistry in 34 different normal organs/tissues, 34 different tumor types and finally in 486 breast cancer samples where possible associations between BMP4 and clinicopathological parameters were statistically evaluated. In over 20% of normal and malignant tissues, BMP4 was expressed at high level. Strong expression was observed particularly in some normal epithelial cells, such as bladder and stomach, and in squamous cell carcinomas. In breast cancer, strong BMP4 expression was detected in 25% of patients, and was associated with low proliferation index and increased frequency of tumor recurrence. Taken together, BMP4 is expressed in a subset of normal adult tissues and is likely to contribute to tissue homeostasis. However, in tumors, BMP4 expression levels vary considerably, implying diverse roles in different tumor types. This role is biphasic in breast cancer as BMP4 expression is linked to reduced proliferation and increased recurrence, thus corroborating our previous in-vitro functional data.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development

Alarmo¹,

Huhtala

Korhonen

et al. 2013

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…Thus, TFF3 may be regarded as tumor suppressor gene, since loss of expression is observed in malignant thyroid tumors. However, tumor suppressor role of TFF3 has not been demonstrated in functional studies to date and while TFF3 is downregulated in colon cancer, TFF3 mRNA is overexpressed in prostate and esophageal cancers [40][41][42].…”

Section: Advantages Of Tff3 As An Indicator Of Thyroid Malignancymentioning

confidence: 99%

Trefoil Factor 3 (TFF3): A Promising Indicator for Diagnosing Thyroid Follicular Carcinoma

Takano

Yamada

2009

Endocr J

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Abstract. Since the introduction of fine needle aspiration biopsy (FNAB) in the 1970's, a preoperative diagnostic technique for thyroid follicular carcinoma has long been awaited. Many markers that distinguish follicular carcinomas from adenomas have been reported; however, most of them have not been confirmed to be beneficial for clinical use. Trefoil factor 3 (TFF3) is a relatively new family of peptides that bears the three-loop trefoil domain. Several groups have reported that the suppression of TFF3 mRNA expression is related to malignant characteristics of thyroid follicular cellderived tumors and the expression level of TFF3 mRNA is the most promising indicator for diagnosing follicular carcinoma. Development of TFF3-based diagnostic methods is now ongoing and it may not be long before thyroid follicular carcinoma can be diagnosed preoperatively using an aspirated sample from the tumor.

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“…The phenotypic changes during the development of Barrett's esophagus have been described in several studies (12)(13)(14)(15). Recently, microarray and other gene expression profile studies have been done showing that, also at the gene expression level, Barrett's esophagus has strong similarities with the anatomic surrounding epithelia (16,17). Nevertheless, at the level of cellular functions and processes, the pathophysiology of Barrett's esophagus is hardly understood.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

Baal

Diks²,

Wanders³

et al. 2006

Cancer Research

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The precursor metaplastic mucosal lesion that predisposes for esophageal adenocarcinoma is Barrett's esophagus. Because the signal transduction events that occur in Barrett's esophagus are poorly understood, this study aimed at generating a comprehensive description of cellular kinase activity in Barrett's esophagus, normal squamous esophagus, and gastric cardia to gain more insight into the pathogenesis of Barrett's esophagus. Peptide arrays, exhibiting 1,176 specific consensus sequences for protein kinases, were used to produce a global analysis of cellular kinase activity in biopsies of Barrett's esophagus, and results were compared with the neighboring cardia and squamous epithelia. Several differences in kinase activity using immunoblot analysis and enzyme activity assays were validated in biopsies of 27 Barrett's esophagus patients. Three unique kinome profiles are described and compared. We identified cascades of activated kinases showing that mitogen-activated protein kinase and epidermal growth factor receptor activity are both significantly altered in Barrett's esophagus compared with squamous and gastric cardia epithelia. Another novel finding is that the glycolysis pathway is significantly up-regulated in Barrett's esophagus, which is illustrated by an up-regulated pyruvate kinase activity. Here, the unique kinome profile of Barrett's esophagus is made available as a comprehensive database. Several signaling pathways are revealed as specifically expressed in Barrett's esophagus when compared with the adjacent normal epithelia. These unique findings provide novel insight in the pathogenesis of Barrett's esophagus that will ultimately help to resolve the increasing problem of Barrett's esophagus and prevention of esophageal adenocarcinoma. (Cancer Res 2006; 66(24): 11605-12)

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A Comparative Analysis by SAGE of Gene Expression Profiles of Barrett’s Esophagus, Normal Squamous Esophagus, and Gastric Cardia

Cited by 78 publications

References 37 publications

Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development

Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development

Trefoil Factor 3 (TFF3): A Promising Indicator for Diagnosing Thyroid Follicular Carcinoma

Comparison of Kinome Profiles of Barrett's Esophagus with Normal Squamous Esophagus and Normal Gastric Cardia

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