A comparative analyses of morphological variations, phagocytosis and generation of cytotoxic agents in flow cytometrically isolated hemocytes of Indian molluscs

Ray, Mitali; Bhunia, Niladri Sekhar; Bhunia, Anindya Sundar; Ray, Sajal

doi:10.1016/j.fsi.2012.11.006

Cited by 31 publications

(22 citation statements)

References 34 publications

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“…Substantial information has been gathered regarding hemocyte structure and function in the ampullariids Pila globosa (see Mahilini & Rajendran, 2008) and P. canaliculata (Shozawa & Suto, 1990;Cueto et al, 2007Cueto et al, , 2013Ray et al, 2012;Accorsi et al, 2013). Recent authors (Mahilini & Rajendran, 2008;Ray et al, 2012;Accorsi et al, 2013) have used various names for the different kinds of hemocytes, but in an attempt to standardize the nomenclature, Cueto et al (submitted) adopted the classical terminology of Cheng (1975), recognizing three types: agranulocytes, hyalinocytes and granulocytes.…”

Section: Ampullariid Hemocytesmentioning

confidence: 99%

“…Recent authors (Mahilini & Rajendran, 2008;Ray et al, 2012;Accorsi et al, 2013) have used various names for the different kinds of hemocytes, but in an attempt to standardize the nomenclature, Cueto et al (submitted) adopted the classical terminology of Cheng (1975), recognizing three types: agranulocytes, hyalinocytes and granulocytes.…”

Section: Ampullariid Hemocytesmentioning

confidence: 99%

“…Agranulocytes constitute 28% of circulating cells in P. canaliculata according to Cueto et al (2013) and are likely to include circulating blasts (Ray et al, 2012;Accorsi et al, 2013), though this hypothesis needs testing. Hyalinocytes are larger cells with membrane-bound granules of moderate electron density and may be lysosomes (Cueto et al, submitted).…”

Section: Ampullariid Hemocytesmentioning

confidence: 99%

See 2 more Smart Citations

Insights from an Integrated View of the Biology of Apple Snails (Caenogastropoda: Ampullariidae)

et al. 2015

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Section: Ampullariid Hemocytesmentioning

confidence: 99%

Section: Ampullariid Hemocytesmentioning

confidence: 99%

Section: Ampullariid Hemocytesmentioning

confidence: 99%

See 1 more Smart Citation

Insights from an Integrated View of the Biology of Apple Snails (Caenogastropoda: Ampullariidae)

et al. 2015

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“…It is considered as the major immunological activity evidenced in many molluscan species [45]. Major cytotoxic molecules such as superoxide anion and nitric oxide generated by the circulatory hemocytes of molluscs are functionally associated with the destruction of pathogens [46,47]. Phenoloxidase is reported to be functionally associated with phagocytosis, self-nonself discrimination, cytotoxicity and melanization response [48].…”

Section: Role Of Snail Hemocytes In Innate Immunitymentioning

confidence: 99%

The Uniqueness of Achatina fulica in its Evolutionary Success

Mukherjee¹,

Sarkar²,

Munshi³

et al. 2017

Organismal and Molecular Malacology

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The increasing load of environmental pollutants poses a serious threat over the globe. In this vulnerable situation, it is essential to have alternative sources of medicines, may be from invertebrates. Among invertebrates, although molluscs are known for their consumption as food and ethno-medicinal use, the importance of these animals is still overlooked. Presently attention has been geared toward molluscs including Achatina fulica which are now considered as one of the most evolutionary successful animals. During the last few decades, researchers are trying to decipher their complex immune system to harvest valuable molecules to treat human diseases. In the present review, the existence of important immunological factors in Achatina is discussed addressing the coagulation system, innate immune molecules, bioactive proteins and lastly the enigmatic C-reactive proteins.

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“…The immune system of snails involves the innate immune response, composed by the humoral defense system, and the cell-mediated immune response (hemocytes), both operating in the processes of killing and eliminating foreign microorganisms (Foley and Cheng, 1972; van der Knaap and Meuleman, 1986;Seta et al, 1996;Yoshino et al, 2008;Comesana et al, 2012). Hemocytes have many functions, including being the main effectors of the immune system (Foley and Cheng, 1972;Seta et al, 1996;Loker, 2010;Ray et al, 2013), and present morphological and biological heterogeneities. The small cells (agranulocytes) have a relatively low immunological competence, whereas the large cells with pseudopodia (semigranulocytes and granulocytes) display enhanced immunological capacities and high phagocytic activity (Cheng, 1984;van der Knaap and Meuleman, 1986;Yoshino et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Hemocyte subpopulation changes in Bithynia snails infected with Opisthorchis viverrini in Thailand.

Suwannatrai

Donthaisong

et al. 2019

Preprint

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The Bithynia snails of B. funiculata, B. siamensis siamensis and B. siamensis goniomphalos, are first intermediate hosts of Opisthorchis viverrini. The success of parasitic infection in snails is related to the host species and efficiency of their internal defense system. Parasitic infections in snails exhibited significant variations in the number of hemocytes in hemolymph. This study investigated hemocyte counts in Bithynia snails for various durations of O. viverrini infection. The three species/subspecies snails were infected with O. viverriniand hemocytes were counted at post-exposed periods of 2, 4, 6, 12, 24, 48, 96 h, and 1, 4 and 8 wk to evaluate the hemocyte response to the infection. Three major hemocyte morphotypes, namely, agranulocytes, semigranulocytes and granulocytes, were observed. After infection, the differential hemocyte morphotype counts in all species/subspecies significantly increased in granulocytes at 2 h (p < 0.05) and decreased in semigranulocytes and agranulocytes at 2 to 4 h (p < 0.05). The total hemocyte counts were significant increased at 2 h after exposure in B. s. siamensis and B. funiculata (p < 0.05). Additionally, the number of hemocytes was reduced after exposure at 4, 6 and 12 h in B. s. goniomphalos and at 12, 24 and 48 h in B. funiculata (p < 0.05). From 96 h to 8 wk, the number of hemocytes was reestablished in the hemolymph, indicating that defensive cells in the host species have different mechanisms for their susceptibility or resistance to parasitic infections. Further studies on molecular functions will be done.

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A comparative analyses of morphological variations, phagocytosis and generation of cytotoxic agents in flow cytometrically isolated hemocytes of Indian molluscs

Cited by 31 publications

References 34 publications

Insights from an Integrated View of the Biology of Apple Snails (Caenogastropoda: Ampullariidae)

Insights from an Integrated View of the Biology of Apple Snails (Caenogastropoda: Ampullariidae)

The Uniqueness of Achatina fulica in its Evolutionary Success

Hemocyte subpopulation changes in Bithynia snails infected with Opisthorchis viverrini in Thailand.

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