First and foremost, I would like to express my deepest appreciation to my supervisor, Prof. Siek Liter, for guiding me into the integrated circuit design field for graduate studies. His encouragements and supports help me to get through many difficult times in my Ph.D. journey. I truly appreciate his priceless guidance, and patience, which helps me to cultivate my analytical thinking and problemsolving skills as well as to explore my own research interest.Furthermore, I would also like to acknowledge with much appreciation the crucial role of my senior, Sun Zhuochao for helping me and sharing his knowledge and experiences with me, which helps to broaden my view on the research works. My thanks and appreciations also go to my fellow teammates, Low Qiong Wei, Zhang Xiang, Xiao Zhekai, etc and all the staffs in VIRTUS as well as in VLSI labs of Nanyang Technological University (NTU) who have willingly helped me out with their abilities. Finally, I would like to extend my gratitude to the Economic Development Board (EDB) and Maxim Integrated for sponsoring my Ph.D. studies. I would like to thank the School of Electrical and Electronic Engineering (EEE) for supporting me for the chip fabrication as well as VIRTUS for providing me a conducive research environment.Last but not least, a special gratitude I give to my family for their continuous moral support and endless love all the while.