A Community study of obstructive sleep apnea hypopnea syndrome (OSAHS) in middle-aged Bangladeshi population

Abstract

Obstructive sleep apnea hypopnea syndrome (OSAHS) is the occurrence of repetitive episodes of complete or partial upper airway obstruction during sleep in association with loud snoring and daytime sleepiness and is a risk factor for hypertension, cardiovascular and cerebrovascular diseases and more. The present study was performed to assess the prevalence as well as the clinical and anthropometric predictors of OSAHS in an urban community of middle aged Bangladeshi population. The study was a cross-sectional, community-based prevalence study which was performed in an urban community in Dhanmondi Thana Pourashava of Dhaka city from July 2007 to June 2008. About 2500 citizens, aged 30-60 years were included in the study. In stage one of the study, they were informed about the polysomnography (PSG) study (stage two of the study) and 2250 of them gave consent. Subjects were then divided into habitual (495) and non-habitual snorers (1755). Among 2250 subjects, the prevalence of obstructive sleep apnea hypopnea (OSAH) in habitual snorers was 48.33% (239/495), and that in non-habitual snorers was 1.66% (29/1755). So, the overall prevalence of OSAH in the screened population was 11.91%, and that of OSAHS was 3.29%. Likewise, the prevalence of OSAH and OSAHS in men were 17.37% and 4.49%, respectively and 6.25% and 2.14% in women. Multivariate analysis revealed that male gender, age, obesity (defined by a high body mass index), waist/hip ratio were significant risk factors for OSAHS. These findings can help us in identifying the prevalence of OSAHS in the community and further planning in the management of obesity and cardiovascular diseases.

Association of plasma fibrinogen level with the severity of obstructive sleep apnoea patients in a tertiary care hospital

“…The prevalence of OSAH among 30-60 years men and women were 17.37% and 6.25% respectively. 2 OSA has been increasingly implicated in cardiovascular and cerebrovascular diseases. [3][4][5] Mechanisms such as increased sympathetic activity, endothelial dysfunction, chronic inflammation, and coagulation are potential mediators of increased risk of cardiovascular diseases.…”

“…10 OSA results in repetitive and severe nocturnal hypoxemia and sleep disturbances. 2 Hypoxemia at high altitude causes increased synthesis of both fibrinogen and cytokines. 11,12 Sleep deprivation also induces an increase in cytokines.…”