A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia

Castillo, E. J.; Camilleri, Michael; Locke, G. Richard; Burton, Duane D.; Stephens, Debra; Geno, Debra M.; Zinsmeister, Alan R.

doi:10.1016/s1542-3565(04)00454-9

Cited by 141 publications

(143 citation statements)

References 39 publications

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“…However, we did not identify significant abnormalities of motility or sensation of the stomach, except for a reduced accommodation volume after a standard small meal in those with the most significant pain precipitated by food and persisting for 2 hours after the meal. As shown by Castillo et al (50) in a community cohort of dyspeptics, somatization and general severity index on SCL-90 was associated with foodrelated dyspepsia rather than abnormal sensation or motility.…”

Section: Dyspepsia and Gastric Function In Ibsmentioning

confidence: 73%

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Camilleri

McKinzie

Busciglio

et al. 2008

Clinical Gastroenterology and Hepatology

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210

174

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Section: Dyspepsia and Gastric Function In Ibsmentioning

confidence: 73%

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Camilleri

McKinzie

Busciglio

et al. 2008

Clinical Gastroenterology and Hepatology

Self Cite

210

174

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“…2,18 Dyspeptic symptoms are often aggravated by food ingestion. Based on questionnaires, up to 75% of dyspeptic patients report a relationship between ingestion of a meal and symptom aggravation, 19,20 and registration of symptoms before and after ingestion of a standardized meal confirmed meal-induced increases in symptom intensity in the majority of patients with functional dyspepsia. 20,21 However, a preliminary study failed to find major differences in demographic, symptomatic, and pathophysiologic characteristics in dyspeptic patients with or without reported meal-induced aggravation.…”

Section: Subgroups Of Functional Dyspepsia Patientsmentioning

confidence: 98%

Pathophysiology and Treatment of Functional Dyspepsia

Tack

Lee

2005

Journal of Clinical Gastroenterology

207

247

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Functional dyspepsia is a highly prevalent symptom complex and a heterogenous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms. Therapeutic options are still limited but targeted therapy directed at the underlying pathophysiology seems desirable. Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required.

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“…This study assessed 466 patients with FGIDs [Rome II positive, 19 with chronic abdominal pain, 175 with diarrhea-predominant IBS (IBS-D) or functional diarrhea, 155 with constipation-predominant IBS (IBS-C) or functional constipation, 84 with IBS-mixed or alternating (IBS-Alt), and 33 with dyspepsia] and 233 healthy volunteers recruited to studies of symptom phenotype and genotype from 2000 -2007 (1,6,11,27). All participants were residents of the region within 150 miles of Rochester, Minnesota.…”

Section: Participantsmentioning

confidence: 99%

Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders

Camilleri

Carlson

Zinsmeister³

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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Our hypothesis is that these mtDNA SNPs are associated with functional GI disorders (FGIDs) and GI functions. The mt genome was first tested for the 7028C polymorphism (defining haplogroup H) in 699 patients or controls, and those with 7028C were further genotyped at 16519 and 3010. Phenotypes were based on symptoms (validated questionnaires and criteria) and GI physiology using validated motor and sensory studies. Constipation-predominant IBS and alternating constipation and diarrhea IBS are less prevalent in individuals with the 7028C mtDNA polymorphism than in individuals with 7028T. Conversely, 7028C is associated with higher maximum tolerated volume (lower satiation) compared with 7028T. Among those with 7028C, nonspecific abdominal pain (chronic abdominal pain or dyspepsia) was significantly associated with 3010A compared with 3010G (odds ratio 3.3, P ϭ 0.02), and slower gastric emptying was statistically associated with 3010G. There were no significant associations of mtDNA genotypes tested and stomach volumes, small bowel or colonic transit, rectal compliance, and motor or sensory functions. Thus variation in mtDNA may be associated with satiation, gastric emptying, and possibly pain; further studies of mtDNA in appetite regulation and larger numbers of patients with FGIDs are warranted.

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A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia

Cited by 141 publications

References 39 publications

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Prospective Study of Motor, Sensory, Psychologic, and Autonomic Functions in Patients With Irritable Bowel Syndrome

Pathophysiology and Treatment of Functional Dyspepsia

Mitochondrial DNA and gastrointestinal motor and sensory functions in health and functional gastrointestinal disorders

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