A common variant near BDNF is associated with dietary calcium intake in adolescents

Dušátková, Lenka; Zamrazilová, Hana; Aldhoon-Hainerová, Irena; Sedláčková, B; Včelák, Josef; Hlavatý, P; Bendlová, Běla; Kunešová, Marie; Hainer, Vojtěch

doi:10.1016/j.nutres.2015.06.004

Cited by 10 publications

(3 citation statements)

References 41 publications

(56 reference statements)

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“…Several studies have examined the relationship between this SNP and dietary fat intake in nonpregnant populations. A significant positive association between the SNP and the absolute total fat intake was found in two previous studies [ 30 , 31 ] but not in two other studies [ 13 , 32 ]. In our study of African American pregnant women, the SNP was nominally significantly related to percentage of energy intake from fat.…”

Section: Discussionmentioning

confidence: 68%

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Meng

Groth

2018

Journal of Nutrition and Metabolism

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Obesity-risk genes have been associated with dietary intake, appetite regulation, and gestational weight gain (GWG). The purpose of this study was to examine whether dietary intake including total energy intake and macronutrients modify or mediate the association between obesity-risk genes and GWG. An observational study was conducted with 85 African American pregnant women. Sociodemographic, medical, and lifestyle factors and dietary recalls were collected during pregnancy. Seven obesity-risk genetic variants were genotyped. Regression analyses with bootstrapping methods were used to examine the moderation and mediation effects of dietary intake. The mean GWG was 14.2 kg, and 55.3% of the women gained above the Institute of Medicine GWG guidelines. A nominally significant association was found between rs17782313 (close to MC4R) and percentage of energy intake from fat (P=0.043). A variant downstream of KCTD15 (rs11084753) was nominally significantly related to GWG (P=0.023). There was a significant interaction between the KCTD15 polymorphism and dietary fat intake (P=0.048). Women with the AG genotype gained more weight during pregnancy with more dietary fat consumption. In conclusion, our results indicate that dietary macronutrients, especially fat intake, may modify the effect of the KCTD15 gene on GWG. Improved knowledge of gene-diet interactions can facilitate the development of personalized interventions.

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Section: Discussionmentioning

confidence: 68%

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Meng

Groth

2018

Journal of Nutrition and Metabolism

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“…In a cohort of Chinese children and adolescents aged 6-15 years, Liang et al observed that the subjects with the AA or AT genotype of the rs9939609 polymorphism had a higher average WC than those with the TT genotype (68.92 vs. 64.25 cm, p = 0.036) [58]. The relation between the rs9939609 polymorphism and WC was confirmed in many other cohorts of children and adolescents, including Europeans [59][60][61][62][63][64][65], Asians [66,67], Latin Americans [68][69][70][71], and North Americans [72]. In all these studies, the A allele of the rs9939609 polymorphism was consistently associated with a higher WC in children and/or adolescents.…”

Section: The Rs9939609 Polymorphism Of Fto Is Related To Larger Wc In...mentioning

confidence: 89%

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

et al. 2023

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Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with a high likelihood of suffering from severe diseases such as cardiovascular disease later in adulthood. MetS is associated with genetic susceptibility that involves gene polymorphisms. The fat mass and obesity-associated gene (FTO) encodes an RNA N6-methyladenosine demethylase that regulates RNA stability and molecular functions. Human FTO contains genetic variants that significantly contribute to the early onset of MetS in children and adolescents. Emerging evidence has also uncovered that FTO polymorphisms in intron 1, such as rs9939609 and rs9930506 polymorphisms, are significantly associated with the development of MetS in children and adolescents. Mechanistic studies reported that FTO polymorphisms lead to aberrant expressions of FTO and the adjacent genes that promote adipogenesis and appetite and reduce steatolysis, satiety, and energy expenditure in the carriers. The present review highlights the recent observations on the key FTO polymorphisms that are associated with child and adolescent MetS with an exploration of the molecular mechanisms underlying the development of increased waist circumference, hypertension, and hyperlipidemia in child and adolescent MetS.

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“…Additionally, BDNF polymorphisms may be differentially associated with obesity, dependent on sex: the rs6265 GG genotype has been correlated with obesity in men but with a lower body mass index (BMI) in women 29 . A study by Duˇs´atkov´a L et al 30 showed that rs925946 may interact with dietary factors, which may affect body weight 31 , 32 .…”

Section: Introductionmentioning

confidence: 99%

Obesity-related parameters in carriers of some BDNF genetic variants may depend on daily dietary macronutrients intake

Miksza

Adamska-Patruno

Bauer

et al. 2023

Sci Rep

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Some common single-nucleotide polymorphisms of the brain-derived neurotrophic factor (BDNF) gene have been associated not only with the neurodegenerative diseases but also with some eating disorders. The aim of this study was to assess the possible differences in the obesity-related and glucose metabolism parameters between some BDNF genotypes’, that may depend on the daily energy and macronutrients intake. In 484 adult participants we performed the anthropometric measurements, body composition analysis, and body fat distribution. The daily dietary intake was assessed using the 3-day food intake diaries. Blood glucose and insulin concentrations were measured at fasting and during oral glucose tolerance tests. Moreover, the visceral adipose tissue/subcutaneous adipose tissue (VAT/SAT) ratio and homeostatic model assessment of insulin resistance were calculated. We noted that participants carrying the GG genotype had lower skeletal muscle mass and fat free mass (FFM) when carbohydrate intake was > 48%, whereas they presented higher fat-free mass (FFM), and surprisingly higher total cholesterol and LDL-C concentrations when daily fiber intake was > 18 g. Moreover, in these subjects we noted higher waist circumference, BMI, and fasting glucose and insulin concentrations, when > 18% of total daily energy intake was delivered from proteins, and higher VAT content and HDL-C concentrations when > 30% of energy intake was derived from dietary fat. Our results suggest that glucose homeostasis and obesity-related parameters in carriers of some common variants of BDNF gene, especially in the GG (rs10835211) genotype carriers, may differ dependently on daily energy, dietary macronutrients and fiber intake.

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A common variant near BDNF is associated with dietary calcium intake in adolescents

Cited by 10 publications

References 41 publications

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

The Association between Obesity-Risk Genes and Gestational Weight Gain Is Modified by Dietary Intake in African American Women

Polymorphisms of Fat Mass and Obesity-Associated Gene in the Pathogenesis of Child and Adolescent Metabolic Syndrome

Obesity-related parameters in carriers of some BDNF genetic variants may depend on daily dietary macronutrients intake

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