A common standard is inappropriate for determining the potency of ultra low molecular weight heparins such as semuloparin and bemiparin

Jeske, Walter; Hoppensteadt, Debra; Gray, Angel; Walenga, Jeanine M.; Cunanan, Josephine; Myers, Lauren; Fareed, Jawed; Bayol, Alain; Rigal, Hélène; Viskov, Christian

doi:10.1016/j.thromres.2011.03.001

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…[11][12][13][14][15] It is known as a secondgeneration LMWH due to its ultra-low molecular weight (3.600 Da). According to its low molecular weight, it has lower anti-factor IIa (thrombin) activity and an anti-Xa: anti-IIa activity ratio of 8:1 versus a ratio of 1:1 for UFHs and dalteparin 2-3:1.…”

Section: Discussionmentioning

confidence: 99%

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The effect of bemiparin on neointimal hyperplasia and endothelial cell proliferation in a rabbit carotid artery model

Gencpinar¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada bemiparinin neointimal hiperplazi ve endotelyal hücre proliferasyonu üzerine olan etkileri bir tavşan karotis arter modelinde araştırıldı. Ça lış mapla nı:Mart 2015 -Nisan 2015 tarihleri arasında rastgele seçilen, 2 ila 3 kg ağırlığında 12 Yeni Zelanda tavşanı iki gruba ayrıldı. Sağ karotis arterler transekte edildi ve 8-0 prolen, devamlı sütur tekniği ile sütüre edildi. Kontrol grubuna (n=6) herhangi bir ilaç verilmez iken, çalışma grubuna (n=6) yedi gün boyunca 150 IU/kg/gün bemiparin verildi. Tavşanların tümü 28. günde sakrifiye edildi ve karotis arter segmentleri çıkarılarak, histolojik inceleme için hazırlandı. Bul gu lar: Tüm histokimyasal ve histomorfolojik analizler gruplara kör iki araştırmacı tarafından yapıldı. Kontrol grubunun damar örneklerinin kesitsel analizinde, tunika intimada kalınlaşma izlendi ve bir kesitte intimal kalınlaşma çok az sayıda rekanalizasyon alanları ile birlikte lümeni neredeyse tamamen tıkamıştı. Bemiparin grubunda, kontrol grubuna kıyasla, intimal hiperplazi (p<0.006) ve tunika media kalınlığı (p<0.018) azalmıştı. Gruplar arasında ortalama luminal çapları ve luminal alanlarının histomorfometrik analizi açısından anlamlı bir fark yoktu (sırasıyla p<0.100, p<0.068). So nuç: Çalışma sonuçlarımız, hayvan modelinde bemiparinin neointimal hiperplazi ve endotelyal hücre proliferasyonunu önleyerek etkisini gösterdiğini ortaya koymaktadır.Anah tar söz cük ler: Aort; bemiparin; karotis arter; intimal hiperplazi; vasküler endotelyal büyüme faktörü. ABSTRACT Background:The aim of this study was to investigate the effects of bemiparin on neointimal hyperplasia and endothelial cell proliferation in a rabbit carotid artery model. Methods: Between March 2015 and April 2015 12 randomly-selected New Zealand male rabbits, weighing 2 to 3 kg, were divided into two groups. The right carotid arteries were transected and sutured with 8-0 polypropylene material with continuous suture technique. The control group (n=8) received no additional medication, while the study group (n=6) received 150 IU/kg/day of bemiparin for seven days. All rabbits were sacrificed on Day 28, and the carotid artery segments were removed and prepared for histological examination. Results: All histochemical and histomorphological analyses were performed by two investigators who were blind to the groups. In the cross-section analysis of the vessel specimens of the control group, thickening of the tunica intima was noticed, and in a section, the intimal thickening was almost occluding the lumen with a few recanalization areas. In the bemiparin group, the intimal hyperplasia (p<0.006) and the thickness of the tunica media decreased (p<0.018), compared to the control group. There was no significant difference in the histomorphometric analysis results of the mean luminal diameters and luminal areas between the groups (p<0.100, p<0.068, respectively). Conclusion: Our study results suggest that bemiparin exerts its effect preventing neointimal hyperplasia and endothelial cell proliferation in animal model.

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Section: Discussionmentioning

confidence: 99%

“…In addition, LMWHs are successful in the prevention and treatment of thromboembolism. [6,[13][14][15][16][17][18][19][20][21][22][23][24][25] They are more effective than UFH in venous thromboembolism (VTE) and non-Q wave myocardial infarction. Routine heparin therapy in this setting is still under debate.…”

Section: Discussionmentioning

confidence: 99%

The effect of bemiparin on neointimal hyperplasia and endothelial cell proliferation in a rabbit carotid artery model

Gencpinar¹

2017

Turk Gogus Kalp Dama

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“…Chemical β-elimination depolymerization 3.500 (Depasse et al, 2003;Dogan et al, 2011;Jeske et al, 2011;Perez-Ruiz et al, 2002;Vignoli et al, 2011;Westmuckett et al, 2001) (Vignoli et al, 2011) These advantages have led to their increasing use in the treatment of cancer as angiogenesis inhibitors. Clinical studies suggest a significant mortality reduction in cancer patients receiving different heparin fractions for the treatment of venous thromboembolism versus those receiving UFH (Akl et al, 2008).…”

Section: Bemiparin Badyketmentioning

confidence: 99%

“…The comparison of the properties of first and second generation heparins is shown in Figure 3 (Norrby, 2006). Bemiparin (Badyket, 3.5 kDa) (Balibrea et al, 2007;Dogan et al, 2011;Jeske et al, 2011;Vignoli et al, 2011) has been available in Europe for 10 years but only recently has been evaluated in clinical trials to determine its angionenic potential in patients with cancer. The efficacy of bemiparin administration in patients limited small cell lung cancer was evaluated in the ABEL study.…”

Section: Second Generation Heparinsmentioning

confidence: 99%