A common polymorphism of the transforming growth factor-β1 gene and coronary artery disease

WANG, X. L.; Sim, Ah-Boon; Wilcken, D. E. L.

doi:10.1042/cs0950745

Cited by 15 publications

(10 citation statements)

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“…17,20 -22 However, other studies reported no associations with risk of CHD. 17,18,20,23 Overall, the sparse results available are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…17,20 -22 However, other studies have reported no association with cardiovascular disease. 17,18,20,23 To our knowledge, none of the polymorphisms was ever studied in relation to the risk of stroke in a general population. We therefore studied the TGF-␤1 Ϫ800 G/A, Ϫ509 C/T, c10, c25, and c263 polymorphisms in relation to the risk of myocardial infarction and stroke in a large population-based study.…”

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confidence: 99%

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TGF-β1 Polymorphisms and Risk of Myocardial Infarction and Stroke

Sie

Uitterlinden

Bos

et al. 2006

Stroke

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Background and Purpose-Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cardiovascular and cerebrovascular complications. Transforming growth factor-␤1 (TGF-␤1) is a pleiotropic cytokine with a central role in inflammation. Little is known of the relation of variations within the gene and risk of cardiovascular and cerebrovascular disease. We therefore investigated 5 polymorphisms in the TGF-␤1 gene (Ϫ800 G/A, Ϫ509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study. Methods-Participants (Nϭ6456) of the Rotterdam Study were included in the current study. Analyses of the relations of genotypes with the risk of myocardial infarction and stroke were performed according to Cox proportional-hazards methods. All analyses were adjusted for age, sex, conventional cardiovascular risk factors, and medical history. Results-We found no association with the risk of myocardial infarction. A significantly increased risk of stroke was found, associated with the T allele of the Ϫ509 C/T polymorphism (relative risk, 1.26; (95% CI, 1.06 to 1.49) and the Pro variant of the codon 10 polymorphism (relative risk, 1.24; 95% CI, 1.04 to 1.48). Conclusions-No association between the TGF-␤1 polymorphisms and myocardial infarction was observed; however, the Ϫ509 C/T and codon 10 Leu/Pro polymorphisms were associated with the risk of stroke.

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“…17,20 -22 However, other studies reported no associations with risk of CHD. 17,18,20,23 Overall, the sparse results available are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

TGF-β1 Polymorphisms and Risk of Myocardial Infarction and Stroke

Sie

Uitterlinden

Bos

et al. 2006

Stroke

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“…16,18 Although no relationship of the Ϫ509C/T, 868T/C, 913G/C, and 11929C/T SNPs with coronary artery disease was found in previous studies, the 868T/C SNP was observed to be associated with MI in a Japanese population and the 913G/C SNP, but not the 868T/C SNP, was reported to be related with MI in some European populations. 16,18,19,22 Among Japanese men, but not women, the carriers of the 868T allele (868TT and 868TC genotypes) were significantly more frequent in the patient group than in the control group. 22 In the European populations in which an association between the 913G/C SNP and MI was found, the 913C allele was present more often among patients than among control subjects.…”

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confidence: 99%

“…16 Taken together, current evidence on the role of the TGFB1 gene polymorphisms in cardiovascular disease shows conflicting results, probably related to the definition of the phenotype of interest. 16,18,19,22 Positive associations have been found between TGFB1 polymorphisms and MI in studies that included control individuals without angiographically verified presence of coronary artery disease. 16,22 On the other side, no association has been found when angiographic coronary artery disease has been the phenotype of interest.…”

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confidence: 99%

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Association of Transforming Growth Factor-β1 Gene Polymorphisms With Myocardial Infarction in Patients With Angiographically Proven Coronary Heart Disease

Koch

Hoppmann

Mueller

et al. 2006

ATVB

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Objective-Transforming growth factor (TGF)-␤1 (TGF-␤1) is a multifunctional cytokine that exhibits vasculoprotective properties. Production and plasma levels of TGF-␤1 are influenced by polymorphisms in the TGF-␤1 gene (TGFB1). We investigated whether the Ϫ509C/T (rs1800469), 868T/C (rs1982073), 913G/C (rs1800471), and 11929C/T (rs1800472) polymorphisms of TGFB1 are associated with myocardial infarction. Methods and Results-The study population consisted of 3657 patients with myocardial infarction (885 women and 2772 men) and 1211 control individuals (598 women and 613 men) with angiographically normal coronary arteries and without signs or symptoms of myocardial infarction. Polymorphism-related genotypes were determined with TaqMan assays and haplotypes were estimated from the genotype data. The Ϫ509C/T polymorphism and Ϫ509C/868T/913G/ 11929C (CTGC) haplotype were associated with myocardial infarction in men, independently from the potentially confounding factors age, arterial hypertension, hypercholesterolemia, cigarette smoking, and diabetes mellitus.

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