A common polymorphism in the 3′-UTR of the NOS1 gene was associated with completed suicides in Japanese male population

Cui, Huxing; Supriyanto, Irwan; Asano, Masaharu; Ueno, Yoshio; Nagasaki, Yasushi; Nishiguchi, Naoki; Sato, Osamu; Hishimoto, Akitoyo

doi:10.1016/j.pnpbp.2010.04.028

Cited by 27 publications

(16 citation statements)

References 40 publications

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“…The 5-HTR6 gene 268 C/T SNP is reported to have a role in men but not in women in a Portuguese sample (Azenha et al, 2009). Recent findings confirm the likelihood of sex differences in suicide risk (Cui et al, 2010; Schenkel et al, 2010). Patients with depression had significantly more lethal suicide attempts in males, and in individuals with the BDNF 66Met allele (Schenkel et al, 2010).…”

Section: Introductionmentioning

confidence: 54%

“…Patients with depression had significantly more lethal suicide attempts in males, and in individuals with the BDNF 66Met allele (Schenkel et al, 2010). A study of Japanese male and female suicide victims found that male suicide completers had a lower frequency of the minor allele of a single SNP in the NOS1 gene compared to both controls and female suicide completers (Cui et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

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Genetic and environmental contributions to self‐reported thoughts of self‐harm and suicide

Althoff

Hudziak

Willemsen³

et al. 2011

American J of Med Genetics Pt B

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Thoughts of self-harm and suicidal behavior are thought to be influenced by both genetics and environment. Molecular genetic studies are beginning to address the question of which genes may be involved and whether different genes may be expressed in men and women. We examined thoughts of self-harm and suicidal behavior in a large general population twin sample including male and female same- and opposite-sex twins. In this study, data on self-reported thoughts of self-harm and suicide were obtained from self-report questionnaires (Beck Depression Inventory and Youth or Adult Self Report forms) in 6265 twin pairs (11,008 individuals) aged 11–90 (62% female) from the Netherlands Twin Registry. Liability threshold models were compared including sex and age (linear and quadratic) effects. Models were compared using measures of parsimony to calculate the simplest model to the data. A model with additive genetic and unique environmental contributions fitted the data for both males and females. There were no qualitative sex differences, but the relative contributions differed between men and women. Heritability was higher in women (0.74, 95% CI 0.65 – 0.81) than men (0.45, 95% CI 0.28 – 0.61). The remaining variance was accounted for by environmental influence unique to an individual. These results suggest contributions from additive genetic factors to self-reported thoughts of self-harm and suicide and support the continued study of both molecular genetic and individual-specific environmental risk factors.

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Section: Introductionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Genetic and environmental contributions to self‐reported thoughts of self‐harm and suicide

Althoff

Hudziak

Willemsen³

et al. 2011

American J of Med Genetics Pt B

View full text Add to dashboard Cite

show abstract

“…This behaviour has a strong genetic background. In a study it was shown that a single nucleotide polymorphism of nNOS gene has a correlation between suicides in Japanese population, especially in males [62].…”

Section: Roles Of Noss In Neuropsychiatric Diseasesmentioning

confidence: 99%

Role of Nitric Oxide Synthase in Normal Brain Function and Pathophysiology of Neural Diseases

Dagdeviren¹

2017

Nitric Oxide Synthase - Simple Enzyme-Complex Roles

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Nitric oxide synthase has three isoforms; according to their roles and tissues or cells they are involved. Neuronal NOS (nNOS) takes place in neuronal signalling, endothelial NOS (eNOS) takes place in vasodilation and inducible NOS (iNOS) takes place in immune responses. nNOS and eNOS are dominant but all isoforms have various roles in the central nervous system. nNOS and eNOS separately or together works in healthy brain during cognitive processes and in unhealthy brain during the pathology of related diseases. These roles were shown by inhibitor applied or by transgenic animal model studies and also by investigating the diseases at the molecular level. Besides, it is possible to say that iNOS has roles in some neurological pathologies creating immune responses. Three different isoforms mainly serve in different systems so there are lots of researchers from various disciplines working collaterally not knowing the others related works about NOSs. Because of this, a comprehensive chapter will be valuable for neuroscientists working with either healthy or unhealthy brains. The purpose of this chapter is to gather an overview of NOSs duties during the normal processes of the brain like learning and memory formation and abnormal processes such as depression, schizophrenia and brain cancers.

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“…In addition to the previously mentioned genetic studies, recent findings have associated several genes with SB, including the angiotensin-converting enzyme (ACE) (Hishimoto et al, 2006;Fudalej et al, 2009;Sparks et al, 2009), the regulator of G-protein signaling 2 (Cui et al, 2008), the corticotropin-releasing hormone receptor-1 (Wasserman et al, 2008), apolipoprotein E (apoE) (Hwang Lethality in suicide attempts 20 suicide attempters 66Met allele was associated with high lethality in SB et al, 2006b), the spermine/spermidine N(1)-acetyltransferase gene (Sequeira et al, 2006), 14-3-3 epsilon (Yanagi et al, 2005), neuronal nitric oxide synthase (Cui et al, 2010), and cholecystokinin (Shindo and Yoshioka, 2005). Although three studies have reported the association between ACE and SB, two studies in the Japanese population found that the "I" allele of the ACE insertion/deletion (I/D) polymorphism is the risk allele for completed suicide (Hishimoto et al, 2006;Fudalej et al, 2009) while a study of Caucasians found that the DD genotype increased suicide (Sparks et al, 2009).…”

Section: Other Candidate Genes With Positive Findingsmentioning

confidence: 99%

Recent molecular genetic studies and methodological issues in suicide research

Tsai

Hong

Liou

2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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A common polymorphism in the 3′-UTR of the NOS1 gene was associated with completed suicides in Japanese male population

Cited by 27 publications

References 40 publications

Genetic and environmental contributions to self‐reported thoughts of self‐harm and suicide

Genetic and environmental contributions to self‐reported thoughts of self‐harm and suicide

Role of Nitric Oxide Synthase in Normal Brain Function and Pathophysiology of Neural Diseases

Recent molecular genetic studies and methodological issues in suicide research

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