A common mutation of cholesteryl ester transfer protein gene in dialysis patients

Abstract

A common mutation of cholesteryl ester transfer protein genein hemodialysis patients [2, 3] and is related to an occurin dialysis patients. rence of ischemic heart disease in hemodialysis patientsBackground. In patients on maintenance hemodialysis, a[4] as well as in the general population. decreased concentration of high-density lipoprotein choles-Recently, a common missense mutation, D442G (Asp terol (HDL-C) is an apparent independent risk factor for vascu-442 to Gly), in exon 15 of the cholesteryl ester transfer lar disease (VD). A common missense mutation of cholesteryl ester transfer protein (CETP) gene, D442G (Asp442 to Gly), protein (CETP) gene has been reported in the Japanese increases HDL-C levels, but the mutation may also diminish general population [5]. CETP mediates the transfer of the activity of reverse cholesterol transport. cholesteryl esters (CEs) from HDL into triglyceride-rich Methods. We compared the genotype distribution of the lipoproteins and thereby stimulates reverse cholesterol D442G polymorphism and postprandial serum lipid levels between patients with and without VD in 414 hemodialysis patransport [6, 7]. The D442G mutation results in markedly tients. increased HDL-C levels [5], whereas the mutation may Results. Serum levels of total cholesterol and HDL-C did reduce activity of reverse cholesterol transport [7].not differ in patients with the mutation [group M (ϩ)] and Whether this mutation affects atherosclerotic complicawithout the mutation [group M (Ϫ)] and in patients with and tions in dialysis patients with uremic dyslipidemia rewithout VD. However, patients with below median HDL-C levels (Ͻ45 mg/dl) had a significantly higher prevalence of VD mains to be clarified. than those with above median HDL levels (26.0 vs. 15.2%, P Ͻ 0.01). Moreover, in this low-HDL-C subgroup, group M (ϩ) patients had a significantly higher prevalence of VD

Alteration of HDL Protein Composition with Hemodialysis Initiation

“…CETP and PLTP mediate HDL cholesterol transport. Although CETP is thought to be proatherogenic in individuals with coronary artery disease (39), evidence suggests that this protein may protect against thrombosis in patients on hemodialysis (40,41). Increased PLTP activity is associated with accelerated atherosclerosis in mice and cardiovascular events in the Framingham Heart Study (42,43).…”

Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with chronic kidney disease

“…We studied the prevalence of vascular disease in children with CKD according to the following criteria [11].…”

Plasma Total Nitric Oxide and Endothelial Constitutive Nitric Oxide Synthase (ecNOS) Inron 4 Gene Polymorphism: A Study in Children with Chronic Kidney Disease

“…We studied the prevalence of vascular disease in children with CKD according to the following criteria [Kimura et al 1999]. Cardiac disease: the presence of primary dilated cardiomyopathy previously diagnosed clinically and by echocardiography.…”