A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations

Joyner, Alexander H.; Roddey, J. Cooper; Bloss, Cinnamon S.; Bakken, Trygve E.; Rimol, Lars M.; Melle, Ingrid; Agartz, Ingrid; Djurovic, Srdjan; Topol, Eric J.; Schork, Nicholas J.; Andreassen, Ole A.; Dale, Anders M.

doi:10.1073/pnas.0901866106

Cited by 109 publications

(104 citation statements)

References 42 publications

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“…The surface area at each vertex in native space was calculated as the average of the surrounding triangles. This value was then compared with the area of the analogous points in registered space to provide an estimate of relative surface areal expansion continuously along the cortical surface (Joyner and Bloss, 2009). Cortical thickness was calculated as the shortest distance between the previous surfaces at each vertex across the cortical surface.…”

Section: Image Processingmentioning

confidence: 99%

Neuroanatomical correlates of late-life depression and associated cognitive changes

Lebedeva

Borza

Håberg

et al. 2015

Neurobiology of Aging

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Section: Image Processingmentioning

confidence: 99%

Neuroanatomical correlates of late-life depression and associated cognitive changes

Lebedeva

Borza

Håberg

et al. 2015

Neurobiology of Aging

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“…Areal maps obtained here were along with the methods described by Joyner et al (2009) and Palaniyappan et al (2011). In the initial tessellation surfaces, number of triangles varies according to the brain size.…”

Section: Surface Reconstruction and Grey Matter Indices Calculationmentioning

confidence: 99%

Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study

Chen

Lin

Zhang

et al. 2015

Brain Imaging and Behavior

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Neural impairments accompanying chronic obstructive pulmonary disease (COPD) have received growing research attention. Previous neuroimaging studies exclusively used volumetric methods to measure cortical volume as a whole rather than focusing on anatomical and neuropathological distinct indices. Here we decomposed the cortical architecture into cortical thickness (CTh), surface area (SA), and gyrification, for the first time, to provide a more integrative profile of brain damage in COPD. Clinical T1-weighted MRI scans were acquired in 25 stable COPD patients (mean age 69) and 25 age-matched controls. Images were processed using surface-based morphometry to obtain cortical parameters enabling more accurate measurement in deep sulci and localized regional mapping. Demographic, physiological, and cognitive assessments were made and correlated with cortical indices. Compared to controls, COPD patients showed significantly reduced CTh broadly distributed in motor, parietal, and prefrontal cortices, together with more circumscribed SA reduction in dorsomedial prefrontal cortex and Broca's area (cluster-level P < 0.05 corrected). No abnormal gyrification was detected. Decreased CTh in parietofrontal networks strongly correlated with visuospatial construction impairment in COPD patients. Furthermore, thinner dorsolateral prefrontal cortex (DLPFC) best predicted poorer performance (r (2) = 0.315, P = 0.004), and was associated with lower arterial oxygen saturation. These data indicate that cortical thinning is a key morphologic feature associated with COPD that could be partly attributed to oxygen desaturation and contributes to COPD visual memory and drawing deficits. Surface-based morphometry provides valuable information concerning COPD, and could ultimately help us to characterize the neurodegenerative pattern and to clarify neurologic mechanisms underlying cognitive dysfunction in COPD patients.

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“…It is also associated with decreased brain cortical area in at least 2 studies [43,44]. Additionally, MECP2 has recently been shown in animal models to be an integral component for GABA release from neurons [45].…”

Section: Irak1 Xq28mentioning

confidence: 99%

The Sex Chromosome Hypothesis of Schizophrenia: Alive, Dead, or Forgotten? A Commentary and Review

Bache

DeLisi

2018

Complex Psychiatry

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The X chromosome has long been an intriguing site for harboring genes that have importance in brain development and function. It has received the most attention for having specific genes underlying the X-linked inherited intellectual disabilities, but has also been associated with schizophrenia in a number of early studies. An X chromosome hypothesis for a genetic predisposition for schizophrenia initially came from the X chromosome anomaly population data showing an excess of schizophrenia in Klinefelter’s (XXY) males and triple X (XXX) females. Crow and colleagues later expanded the X chromosome hypothesis to include the possibility of a locus on the Y chromosome and, specifically, genes on X that escaped inactivation and are X-Y homologous loci. Some new information about possible risk loci on these chromosomes has come from the current large genetic consortia genome-wide association studies, suggesting that perhaps this hypothesis needs to be revisited for some schizophrenias. The following commentary reviews the early and more recent literature supporting or refuting this dormant hypothesis and emphasizes the possible candidate genes still of interest that could be explored in further studies.

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A common MECP2 haplotype associates with reduced cortical surface area in humans in two independent populations

Cited by 109 publications

References 42 publications

Neuroanatomical correlates of late-life depression and associated cognitive changes

Neuroanatomical correlates of late-life depression and associated cognitive changes

Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study

The Sex Chromosome Hypothesis of Schizophrenia: Alive, Dead, or Forgotten? A Commentary and Review

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