A B S T R A C T While fatigue crack growth in vacuum may occur by slip alone, environmental fatigue including crack growth in air is strongly influenced by crack-tip surface chemistry that adversely affects ductility. Cumulative diffusion, combined with adsorption and chemisorption in the loading half-cycle may promote instantaneous crack extension by brittle microfracture (BMF). Unlike slip, the BMF component will be sensitive to parameters that affect near-tip stresses, such as load history and constraint. BMF dominates near-threshold environmental fatigue. Being a surface phenomenon, it loses its significance with increasing growth rate, as slip-driven crack extension gains momentum and growth becomes less sensitive to environment. The BMF model provides for the first time, a scientific rationale for the residual stress effect as well as the related connection between stress-strain hysteresis and load-sequence sensitivity of metal fatigue including notch response. Experimental evidence obtained on a variety of materials under different loading conditions in air and vacuum appears to support the proposed model and its implications.