A commentary on the impact of modelling results to inform mission planning and shield design

El-Jaby, Samy; Lewis, Brent J.; Tomi, Leena

doi:10.1016/j.lssr.2019.11.002

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Outside of the Earth's protective magnetosphere, crews are exposed to galactic cosmic rays (GCR) and solar proton events (SPE) that occur when particles emitted by the sun, mostly protons, become accelerated in the interplanetary space due to a coronal mass ejection shock [1]. The exposure to GCR in the form of high-energy (HZE) ions, secondary protons, and neutrons has high linear energy transfer values that evoke complex DNA and other cellular damage [2].…”

Section: Introductionmentioning

confidence: 99%

The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms

Stati

Passaretta

Gindraux

et al. 2021

Life

View full text Add to dashboard Cite

In the framework of space flight, the risk of radiation carcinogenesis is considered a “red” risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions. The cyclic AMP response element-binding protein (CREB) is overexpressed both in haematological malignancies and solid tumours and its expression and function are modulated following irradiation. The CREB protein is a transcription factor and member of the CREB/activating transcription factor (ATF) family. As such, it has an essential role in a wide range of cell processes, including cell survival, proliferation, and differentiation. Among the CREB-related nuclear transcription factors, NF-κB and p53 have a relevant role in cell response to ionising radiation. Their expression and function can decide the fate of the cell by choosing between death or survival. The aim of this review was to define the role of the CREB/ATF family members and the related transcription factors in the response to ionising radiation of human haematological malignancies and solid tumours.

show abstract

Section: Introductionmentioning

confidence: 99%