A commentary on ‘Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: a retrospective cohort study’ (Int J Surg 2022;105:106843)

Zhou, Zheyu; Liu, Jinsong; Xu, Xiaoliang

doi:10.1097/js9.0000000000000119

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…However, simultaneous testing for AFP and AFP-L3 may add to the financial burden of patients. Previous studies showed that PIVKA-II had a higher positivity rate than AFP in detecting resectable HCC and predicting early recurrence of HCC after hepatectomy [ 13 , 14 ]. A recently published expert consensus also affirmed the clinical usefulness and value of PIVKA-II in monitoring treatment outcomes and recurrence after the operation [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Research progress of protein induced by vitamin K absence or antagonist II in liver transplantation for hepatocellular carcinoma

Zhou,

Liu,

Liu

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Research progress of protein induced by vitamin K absence or antagonist II in liver transplantation for hepatocellular carcinoma

Zhou,

Liu,

Liu

et al. 2024

Heliyon

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“…Both Wang et al and Zhou et al showed that the preoperative DCP positivity rate for resectable HCC was significantly higher than that of the AFP positivity rate. 26,27 Besides, a notably higher proportion of patients with positive AFP and DCP had MVI and E-S grade III-IV. 27 Many previous studies have confirmed that elevated AFP and DCP are independent risk factors for MVI, 21,25,28 although the cutoff values differ.…”

mentioning

confidence: 99%

“…26,27 Besides, a notably higher proportion of patients with positive AFP and DCP had MVI and E-S grade III-IV. 27 Many previous studies have confirmed that elevated AFP and DCP are independent risk factors for MVI, 21,25,28 although the cutoff values differ. Our study revealed that higher levels of tumor markers were also linked to poor HCC differentiation.…”

mentioning

confidence: 99%

A Novel Nomogram for the Preoperative Prediction of Edmondson-Steiner Grade III-IV in Hepatocellular Carcinoma Patients

Zhou,

Cao,

Chen

et al. 2023

JHC

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Background Edmondson-Steiner (E-S) grade is a pathological indicator of the degree of hepatocellular carcinoma (HCC) differentiation, and E-S grade III–IV is a poor prognostic factor for HCC patients. Predicting poorly differentiated HCC has essential significance for clinical decision-making. Although some studies have developed predictive models based on magnetic resonance imaging (MRI) and radiomics, radiomic features that require specific software for analysis are impractical for clinical work. This study aims to develop a novel and user-friendly nomogram model to predict E-S grade III–IV. Patients and Methods Medical data on patients meeting the inclusion criteria were obtained from the Nanjing Drum Tower Hospital HCC database (January 2020 to December 2022). Univariate analysis was used to screen for risk factors associated with E-S grade III–IV. A novel nomogram was established based on the subsequent multivariate logistic regression analysis. The performance of the established model was evaluated through diagnostic ability, calibration, and clinical benefits. Results Overall, 240 HCC patients were included in this study. Among them, 103 were highly differentiated (E-S grade I–II) HCC and 137 were poorly differentiated (E-S grade III–IV) HCC. A nomogram model that integrated alpha-fetoprotein (AFP), des-γ-carboxy prothrombin (DCP), hepatitis B virus surface antigen (HBsAg), hepatitis C virus antibodies (HCVAb), aspartate aminotransferase to lymphocyte ratio index (ALRI), and macrovascular invasion was established. The novel model had a good diagnostic performance with an area under the curve (AUC) value of 0.763. Meanwhile, the model had a diagnostic accuracy of 72.5%, a sensitivity of 78.1%, and a specificity of 65.1%. The calibration curve showed good calibration of the nomogram model (mean absolute error = 0.043), and the decision curve analysis (DCA) demonstrated that the clinical benefit was provided. Conclusion Our developed nomogram model could successfully predict E-S grade III–IV in HCC patients, which may be helpful in clinical decision-making.

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A commentary on ‘Prothrombin induced by vitamin K Absence-II versus alpha-fetoprotein in detection of both resectable hepatocellular carcinoma and early recurrence after curative liver resection: a retrospective cohort study’ (Int J Surg 2022;105:106843)

Cited by 2 publications

References 5 publications

Research progress of protein induced by vitamin K absence or antagonist II in liver transplantation for hepatocellular carcinoma

Research progress of protein induced by vitamin K absence or antagonist II in liver transplantation for hepatocellular carcinoma

A Novel Nomogram for the Preoperative Prediction of Edmondson-Steiner Grade III-IV in Hepatocellular Carcinoma Patients

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