“…Tramadol is a highly toxic opioid, causing severe side effects, such as withdrawal syndrome, respiratory distress, rhabdomyolysis, acute renal failure, seizures, and death [5]. In recent years, tramadol withdrawal syndrome and its treatment have become an important issue in the healthcare system [6]. Symptoms of tramadol-induced withdrawal syndrome are restless legs syndrome, insomnia, irritability, diarrhea, insomnia, abdominal spasm, headaches of migraine type, dysfunction of the autonomic system, and myoclonus in extremities [7,8].…”