A Commemoration of the 70th Anniversary of Pius XII's Coronation on March 12, 2009

Marchione, Margherita

doi:10.5840/cssr20091424

Cited by 2 publications

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“…Therefore, a vital formulation attribute called the sustained released and immediate release tile lag period was chosen and researched. 12,13…”

Section: Optimization Studiesmentioning

confidence: 99%

Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases

Adimulapu,

Devhare,

Patil

et al. 2023

IJDDT

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Objectives: The purpose of the investigation was to extend and evaluate the novel mini tablet cap for treating cardiovascular disease at a desired combinational therapeutic activity and to improve patient compliance. A cheap four-in-one pill can guard against heart attacks and stroke. Methods and Materials: The drug product was manufactured by mini tablet cap technology. The technology was designed to initially use hydrochlorothiazide, simvastatin immediate release, metoprolol succinate, and asprin sustained release to reach the therapeutic levels at prolonged therapy. The two mini-bilayer tablets were prepared by wet granulation method and compression coated with a hydrophobic and hydrophilic polymer like ethyl cellulose and super disintegrating agents to release simvastatin and hydrochlorothiazide immediately. Results: Fourier transformer infrared spectroscopy (FTIR) studied the interaction studies of four chosen drugs. The mini tablet cap technology was designed as two mini bi-layer tablets in a capsule. The quantitative detection of four individual drugs was determined by using the RP-HPLC method. It was found that RP-HPLC is sensitive, reproducible, and valid for determining the mini tablet cap. The in-vitro drug release studies found that simvastatin and hydrochlorothiazide release 90% immediately within 20 minutes. Metoprolol and aspirin controlled the release for up to 24 hours, and drug release kinetics found that the drug release behavior of the optimized formulation followed first-order kinetics. Conclusion: The mini tablet cap is one of the best dosage forms to treat cardiovascular diseases. Because it was reported, the combination of these four drugs reduces mortality by 83% in high-risk patients with heart diseases, hypertension, diabetes, and obesity. The novel mini tablet cap approach data revealed a promising formula for improved relief of patient complaints during treatment or prevention of cardiovascular diseases

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“…Therefore, a vital formulation attribute called the sustained released and immediate release tile lag period was chosen and researched. 12,13…”

Section: Optimization Studiesmentioning

confidence: 99%

Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases

Adimulapu,

Devhare,

Patil

et al. 2023

IJDDT

View full text Add to dashboard Cite

show abstract

“…There may also be demand surges for specific medicines based on media coverage, emerging evidence of benefit, or other factors. These events, such as those that have already occurred for acetaminophen and hydroxychloroquine, may contribute to “stock outs” at distributors and pharmacies and, if left unregulated, worsened access for many in need . Federal and state regulators, as well as distributors and pharmacies, should take several emergency response and preparedness measures to address these possibilities.…”

mentioning

confidence: 99%

Ensuring Access to Medications in the US During the COVID-19 Pandemic

Alexander

Qato

2020

JAMA

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The coronavirus disease 2019 (COVID-19) pandemic continues to rapidly evolve. Given the origins of COVID-19 in China, there were initial concerns regarding medication shortages due to the reliance of the US on overseas manufacturing of active pharmaceutical ingredients. 1,2 Although no major disruptions in pharmaceutical access have occurred thus far, the future of the pandemic and its effect on the US drug supply remains far from certain. The pharmaceutical supply chain represents a series of interdependent steps that ultimately produce the products that are used by consumers in the US. From manufacturers, pharmaceuticals are shipped through wholesalers or distributors and on to retail, specialty, and mail-order pharmacies as well as to hospitals, nursing homes, prisons, clinics, and other sites of care. Retail pharmacies have an especially important role in this process, dispensing more than 85% of all prescription medications in the US. 3 From manufacturers to end users, the pharmaceutical supply chain is vast, employing tens of thousands of workers who manage the annual distribution of an estimated nearly 6 billion prescriptions in the US. 3

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A Commemoration of the 70th Anniversary of Pius XII's Coronation on March 12, 2009

Cited by 2 publications

References 0 publications

Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases

Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases

Ensuring Access to Medications in the US During the COVID-19 Pandemic

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