A Combined Quantitative Chemical, Light, and Electron Microscope Study of Aortic Development in Normal and Nitrile‐treated Mice

Fyfe, F. W.; Gillman, Theodore; Oneson, Irving B.

doi:10.1111/j.1749-6632.1968.tb53822.x

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…9 BAPN is an irreversible inhibitor of LOX and LOX-like proteins that is presumed to not affect already crosslinked elastic fibers. 6,47 This age-dependency of BAPN-induced aortopathies may reflect that elastic fibers are actively crosslinked for their maturation when mice are 3-4 weeks old, while elastic fibers in the aortic wall have already been mature in 26-weekold mice, which do not require crosslinking of elastic fibers unless pathological insults lead to disruption of the already formed elastic fibers. 9,[47][48][49] It is also worth noting that aortic rupture rate was higher in mice started BAPN administration at 3 weeks of age than at 4 weeks of age.…”

Section: Discussionmentioning

confidence: 99%

β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice

Franklin,

Sawada,

Ito

et al. 2023

Preprint

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This study characterized β-aminopropionitrile (BAPN)-induced aortopathies in young mice. The effects of BAPN were first determined with regard to BAPN dose and mouse strain, age, and sex. BAPN-induced aortic rupture predominantly occurred or originated in the descending thoracic aorta. For mice surviving 12 weeks of BAPN administration, profound dilatation was consistently observed in the ascending region, while there were more heterogeneous changes in the descending thoracic region. Pathological features were distinct between the ascending and descending thoracic regions. Aortic pathology in the ascending region was characterized by luminal dilatation and elastic fiber disruption throughout the media. The descending thoracic region frequently had dissections with false lumen formation, macrophage infiltration, collagen deposition, and remodeling of the wall surrounding the false lumen. Cells surrounding the false lumen were predominantly positive for α-smooth muscle actin. To investigate the molecular basis of the regional heterogeneity, ascending and descending thoracic aortas were harvested after one week of BAPN administration prior to the appearance of overt pathology. BAPN compromised contractile properties in both regions equivalently, and RNA sequencing did not show obvious differences between the two aortic regions in smooth muscle cell markers, cell proliferation markers, and extracellular components. In conclusion, BAPN-induced pathologies show distinct, heterogeneous features within and between ascending and descending aortic regions in young mice.

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Section: Discussionmentioning

confidence: 99%

β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice

Franklin,

Sawada,

Ito

et al. 2023

Preprint

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show abstract

“…Certain small diverticula or buried pockets with dark fringes ( Figure 4) show a patchwork appearance alongside the internal elastic lamina (Fyfe et al, 1968). These pockets may widen as fibrils are added to their sides and blend in with neighboring ones to thicken the internal elastic lamina.…”

Section: Plasma Triglyceridesmentioning

confidence: 99%

“…These subendothelial smooth muscle cells are arranged longitu dinally. Endothelial cells appear to form at least the subendothelial proelastin fibrils, in lesser amount but exactly like the medial cells (Fyfe et al, 1968). Work by Pease and Paule (1960) showed that the endo thelial side of the internal elastic membrane of the aorta was seen to contain areas where probably elastin formation was in progress at the time of tissue preservation.…”

mentioning

confidence: 98%

“…Spicular attachments are fewer where a second element, collagen, is abundant. Fyfe et al (1968) suggested that spicules under tension may be released and retracted into the substance of the elastic laminae. This could provide a source and way for successive amounts of elastin needed in circumferential and longi tudinal growth of the artery.…”

mentioning

confidence: 99%

“…Regarding the origin of elastin, Fyfe et al (1968) found groups of fine electron-dense fibrils, considered to be proelastin, projecting from a developing smooth muscle cell, better known as a multifunctional mesenchyme cell. These fibrils were then seen connecting with less electron-dense islets of homogeneous elastin.…”

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confidence: 99%

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Arterial fine structure and blood chemistry changes induced by periodic starvation and refeeding a high carbohydrate diet

Roloff¹

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Arterial Fine Structure and Pathophysiological Change 3 Fine structure of muscular arteries 3 Fine structural alterations in the induced state Effects of inadequate nutrition, starvation, and refeeding on the cardiovascular and related systems Lipoproteins Physical and chemical properties of lipoproteins Human lipoprotein patterns Composition and distribution of human lipoproteins Nutritional alterations of composition and distribution of the human lipoproteins 49 Genetic and disease alterations of human lipoproteins 54 Relationship of human lipoprotein alterations and etiology of heart and blood vessel diseases 56 Dog lipoprotein patterns 60 Composition and distribution of dog lipoproteins 60 Nutritional alterations of composition and distribution of dog lipoproteins 63

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Structure of mammalian portal vein: Postnatal establishment of two mutually perpendicular medial muscle zones in the rat

1971

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In all mammalian species examined thus far, the media of the adult mammalian portal vein consists of two mutually perpendicular smooth muscle zones separated by a fibrous layer. The cells of the muscle zone nearest the intima are arranged circumferentially and resemble smooth muscle of other vessels; the muscle cells of the thicker, vascularized outer zone are longitudinal and contain mitochondria and pinocytotic vesicles in great abundance, suggesting relatively high metabolic activity. The adult configuration is not present at birth and only develops during the first three postnatal weeks in the rat. Partitioning of the media commences at about three days and contrasting orientation and composition of the cells of the two muscle zones is not established until seven to ten days after birth. Vasa vasorum appear in the outer muscle layer at about two weeks and nerve fibers appear even later. Post-natal establishment of a special, double layered neuromuscular structure may be related to the adaptation of the portal circulation to the effective closure of the ductus venosus.

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A Combined Quantitative Chemical, Light, and Electron Microscope Study of Aortic Development in Normal and Nitrile‐treated Mice

Cited by 8 publications

References 31 publications

β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice

β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice

Arterial fine structure and blood chemistry changes induced by periodic starvation and refeeding a high carbohydrate diet

Structure of mammalian portal vein: Postnatal establishment of two mutually perpendicular medial muscle zones in the rat

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