A combined effect of Cavacurcumin, Eicosapentaenoic acid (Omega-3s), Astaxanthin and Gamma –linoleic acid (Omega-6) (CEAG) in healthy volunteers- a randomized, double-blind, placebo-controlled study

Birudaraju, Divya; Cherukuri, Lavanya; Kinninger, April; Chaganti, Bhanu T.; Shaikh, Kashif; Hamal, Sajad; Flores, Ferdinand; Roy, Sion K.; Budoff, Matthew J.

doi:10.1016/j.clnesp.2019.09.011

Cited by 23 publications

(10 citation statements)

References 36 publications

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“…In this way, it has been included in two clinical trials (NCT03945526 and NCT03906825). The first one is related to effects of astaxanthin on antioxidant parameters in stroke patients, whereas the second one relied on effects of a dietary supplement containing astaxanthin on inflammation markers (Birudaraju et al 2020). Talukdar et al (2020a) brought arguments to consider this compound as a serious natural molecule to alleviate the risk of cytokine storm in some Covid-19 patients thanks to its anti-inflammatory properties.…”

Section: Discussionmentioning

confidence: 99%

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

Vernès²,

Cadoret³

2021

J Appl Phycol

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A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of photosynthetic organisms is regularly highlighted but paradoxically little exploited in view of the tremendous possibilities it offers. Computational tools allow not only to clear the existence and activity of many molecules but also to model their relationships with receptors identified in potential hosts. On a routine basis, our laboratory carries out a research activity on functionalities of molecules derived from algae using in silico tools. We have implemented our skills in algae biology and in modeling, as tests in order to identify molecules expressed by the genus Arthrospira showing an antiviral potential and more particularly anti-SARS-CoV-2. Using consensus docking and redocking with Autodock Vina and SwissDock, we were able to identify several promising molecules from Arthrospira: phycocyanobilin, phycoerythrobilin, phycourobilin, and folic acid. These four compounds showed reliable binding energies comprised between − 6.95 and − 7.45 kcal.mol −1 in Autodock Vina and between − 9.285 and − 10.35 kcal.mol −1 with SwissDock. Toxicity prediction as well as current regulations provided promising arguments for the inclusion of these compounds in further studies to assess their ability to compete with the SARS-CoV-2/ACE2 complex both in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

Vernès²,

Cadoret³

2021

J Appl Phycol

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“…Meanwhile, the atherosclerotic lesions were signi cantly reduced compared with the control group [21]. The research ndings by Birudaraju D, et al showed that active group subjects (Contains astaxanthin) could improve the endothelial function and reduce SBP at 4 weeks [20].…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin and risk of cardiovascular diseases: a meta-analysis of epidemiological evidence

Gao

et al. 2022

Preprint

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Background: The purpose of this study was to analyze and evaluate the effect of astaxanthin on clinical indicators related to cardiovascular disease. Methods: Fives databases include PUBMED, CNKI, WEIPU, WAN FANG and ClinicalTrials were searched up to January 31, 2022, and the random-effects model was used to calculate the summary risk. A total of 14 epidemiological studies were included in this meta-analysis.Results: The overall study showed no significant dose-response association of astaxanthin (AST) with diastolic blood pressure, DBP (weighted mean difference, WND:-0.186, 95%confidence interval, CI:-0.374 to 0.002, P=0.052) and body mass index, BMI ( WND:0.095, 95%CI: -0.164 to 0.354, P=0.473).However, the results revealed that astaxanthin can significantly reduce the concentrations of total cholesterol (WND:-0.310, 95% CI:-0.541 to -0.168, P=0.000), the concentrations of low-density lipoprotein cholesterol, LDL-C (WND: -0.207, 95% CI: -0.396 to -0.019, P=0.031), the concentrations of triglyceride (WND:-0.603, 95% CI:-1.028 to -0.179, P=0.005), the concentrations of glucose (WND: -0.353, 95% CI:-0.596 to -0.110, P=0.004) and systolic blood pressure, SBP(WND:-0.258, 95% CI:-0.495 to -0.021, P=0.033). Moreover, astaxanthin could increase the concentrations of high-density lipoprotein cholesterol, HDL-C (WND: -0.294, 95% CI:-0.515 to -0.072, P=0.009).Conclusions: This meta-analysis indicates that astaxanthin has a protection role on the cardiovascular system. Further studies need to be conducted to verify the findings.

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“…It is important to highlight astaxanthin as a differentiated antioxidant, which indicates a potential 10 times greater when compared to other carotenoids (eg, zeaxanthin, lutein, beta-carotene) 19 and from 10 to 100 times more efficient when compared to vitamin E 15 and vitamin C 34 . This values its functional benefits, complementary to food, for antioxidant and anti-inflammatory demands, involved in chronic diseases and metabolic syndrome.…”

Section: Limitations Of Methods Used In Clinical Trialsmentioning

confidence: 99%

“…In this case, therefore, supplementation indicated to be an important natural alternative for the treatment, control and prevention of childhood obesity and its consequences (table 1). Therefore, the clinical trial developed by Birudaraju et al (2019) 34 recruited 80 volunteers, aged between 18 and 75 years (men and women), divided into 2 groups: 62 people received 2 capsules containing 3mg of astaxanthin each, in a nutraceutical combination. The orientation was to organize the therapeutic regimen twice a day, for 4 weeks.…”

Section: Human Studiesmentioning

confidence: 99%

Astaxanthin supplementation extracted from Haematococcus pluvialis on clinical parameters associated with chronic diseases and metabolic syndrome / Suplementação de astaxantina extraída de Haematococcus pluvialis sobre os parâmetros clínicos associados com doenças crônicas e síndrome metabólica

Altoé¹,

Paes²,

Cirino³

et al. 2022

BJDV

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Introduction: astaxanthin is a carotenoid compound found in marine organisms that, according to several studies, has significantly increased antioxidant properties, with possible benefits for the prevention and treatment of chronic diseases and metabolic syndrome. Objective: to indicate the possible biological effects of astaxanthin, as well as its forms of prescription and possible benefits for the prevention and treatment of chronic diseases and metabolic syndrome. Method: integrative review of clinical experimental studies, mainly, but of some pre-clinical studies, also published since 2000. The searches were carried out in the following databases: Pubmed, SciELO and Semantic Scholar. Results: the results indicated doses between 0.5 and 21.6mg/day, for a period from 2 weeks to 12 months, involving volunteers aged between 8 and 85 years, both genders. Supplements with astaxanthin indicated the ability to reduce oxidative stress, as well as biochemical parameters in the blood, such as low-density lipoprotein, total cholesterol, fasting glucose, triglycerides, glycated hemoglobin and others. The bioactive substance is also associated with a reduction in blood pressure, increased blood operations of high-density lipoprotein and adiponectin, reinforcing the hypothesis that astaxanthin is promising, as an aid in the prevention and treatment of chronic diseases and metabolic syndrome. Conclusion: astaxanthin appears to be a complementary and innovative element for the prevention and treatment of chronic diseases and metabolic syndrome. However, no supplement will have a “miraculous” effect and will replace with constant changes in lifestyle, including healthy eating. The antioxidant effects of astaxanthin were confirmed and associated with the most varied metabolic and clinical outcomes. However, due to the reduced amount of evidence and heterogeneity of variables, further research is needed.

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A combined effect of Cavacurcumin, Eicosapentaenoic acid (Omega-3s), Astaxanthin and Gamma –linoleic acid (Omega-6) (CEAG) in healthy volunteers- a randomized, double-blind, placebo-controlled study

Cited by 23 publications

References 36 publications

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Astaxanthin and risk of cardiovascular diseases: a meta-analysis of epidemiological evidence

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