A combined computational and experimental methodology to determine the adhesion properties of stent polymer coatings

Hopkins, C.; McHugh, Peter E.; O’Dowd, Noel P.; Rochev, Yuri; McGarry, J. Patrick

doi:10.1016/j.commatsci.2013.03.029

Cited by 24 publications

(16 citation statements)

References 48 publications

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“…Computational modeling is a powerful tool in the medical device industry due to its ability to give insights into various aspects of the device performance, which may consequently improve its clinical outcome [14,15,16]. In this study, finite element models were developed to evaluate the mechanical integrity of the spherical occlusion device by the following steps: Step 1

Expand the device to spheres of 2.0, 3.0, 4.0 and 5.2 mm in diameter and anneal it after each expansion to relieve residual stresses.

Step 2

Crimp the spherical occlusion device inside a cylindrical catheter with an inner diameter of 1.6 mm for delivery.

Step 3

Release the spherical occlusion device inside an artery with a diameter of 5.2 mm.

…”

Section: Methodsmentioning

confidence: 99%

A Novel Nitinol Spherical Occlusion Device for Liver Cancer

Hsiao

Wang

et al. 2016

Materials

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Liver cancer or hepatic cancer is a cancer that originates in the liver. It is formed from either the liver itself or from structures within the liver, including blood vessels or the bile duct. Liver cancer can be a life-threatening condition, but it may be cured if found early. Hepatic artery embolization is one of the treatment options involving the injection of substances to reduce the blood flow to cancer cells in the livers of patients with tumors that cannot be removed by surgery; however, this treatment has some limitations. In this paper, we propose a novel nitinol “spherical occlusion device” concept, the first of its kind in the world. Our proposed spherical occlusion device is able to reduce the blood flow to cancer cells by deploying it in the upstream hepatic artery supplying blood to the liver. Moreover, it could carry multiple chemotherapy or radioactive drugs for delivery directly to the target site. Nitinol alloy was chosen as the device material due to its excellent super-elastic property. Computational models were developed to predict the mechanical response of the device during manufacturing and deployment procedures, as well as its hemodynamic behavior. Simulation results showed that the presence of the spherical occlusion device with 14%–27% metal density deployed at the upstream location of the right hepatic artery had significant occlusion effects, with the average blood flow rate cut down by 30%–50%. A pulsed fiber laser and a series of expansions and heat treatments were developed to make the first prototype of the spherical occlusion device for the demonstration of our novel concept.

show abstract

Expand the device to spheres of 2.0, 3.0, 4.0 and 5.2 mm in diameter and anneal it after each expansion to relieve residual stresses.

Step 2

Crimp the spherical occlusion device inside a cylindrical catheter with an inner diameter of 1.6 mm for delivery.

Step 3

Release the spherical occlusion device inside an artery with a diameter of 5.2 mm.

…”

Section: Methodsmentioning

confidence: 99%

A Novel Nitinol Spherical Occlusion Device for Liver Cancer

Hsiao

Wang

et al. 2016

Materials

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“…Except those inverse analysis methods, other methods that combined the experimental and computational work are developed as well. Hopkins et al [30] established the relations between adhesion properties and the geometrical parameters through FE-simulations and then determined the real interfacial parameters using those relationships and experimental data. Even Journal of Adhesion Science and Technology 1119 though those methods succeeded in individual cases, an effective way of identifying the rate-dependent fracture properties of adhesive interface involving LSY has yet to be developed.…”

Section: Introductionmentioning

confidence: 99%

Extraction of rate-dependent fracture properties of adhesive interface involving large-scale yielding

Zhou

Xiong

Niu

et al. 2015

Journal of Adhesion Science and Technology

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Interface debonding is one of the major failure modes for the adhesive joints of polymer-matrix composites. The interfacial fracture properties of adhesive interfaces involving large-scale yielding is difficult to determine. A hybrid method that combines modified data reduction and inverse analysis was used to determine the fracture energy of the composite propellant/insulation interface at different loading rates. The modified data reduction adopts effective crack length to account for the effect of the fracture progress zone and avoid monitoring the crack length. These estimated values of the fracture energy were then calibrated by inverse analysis based on the Hooke-Jeeves algorithm in which the interface layer is characterized by a cohesive zone model. The whole process of inverse analysis is conducted automatically without any intervention by procedures. Experimental and numerical results indicate that the proposed data reduction provided fracture energy sufficiently similar to those obtained by the inverse analysis. Moreover, the fracture energy of the propellant/ insulation interface was found to rely heavily on the loading rate with a nonmonotonic trend.

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“…Interface strength as a function of temperature and humidity is described by the peeling test in ASTM D903‐98(2017) . This analysis was successfully applied for polyurethane‐based coatings, or to evaluate the effect of surface functionalization onto coating adhesion . The amount of peeled coating surface is calculated by the Cross Hatch Tape test, according to ASTM D3359‐02 .…”

Section: Introductionmentioning

confidence: 99%

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

Gagliardi

2019

J of Applied Polymer Sci

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This work explores the adhesion properties of polymer solutions and thin coatings obtained by different‐composition poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers. Surface wettability, work of adhesion, and work of spreading are calculated for solutions. Increasing amounts of n‐butylmethacrylate lead to higher values of work of adhesion, measured over two stent‐like flat surfaces (AISI 316L and pyrolytic carbon). The same moiety induces the solution viscosity increase and the decrease of the work of spreading and allows obtaining more homogeneous coatings. Adhesion of thin coatings is tested in dry (cross‐cut test) and wet (immersion) conditions. Adhesion tests of coatings obtained by solvent casting reflect thermodynamic parameters evaluated for solutions. Coatings show better strength in cross‐cut tests and a prolonged adhesion in wet conditions by raising the n‐butylmethacrylate fraction. The same trends are confirmed in commercial devices. In conclusion, the study of thermodynamic solution/substrate interactions can explain coating properties. The proposed approach is worthwhile to improve deposition procedures based on polymer solutions. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47814.

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A combined computational and experimental methodology to determine the adhesion properties of stent polymer coatings

Cited by 24 publications

References 48 publications

A Novel Nitinol Spherical Occlusion Device for Liver Cancer

A Novel Nitinol Spherical Occlusion Device for Liver Cancer

Extraction of rate-dependent fracture properties of adhesive interface involving large-scale yielding

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

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