A Combined Bioinformatics and Literature Based Approach for Identification of Long Non-coding RNAs That Modulate Vitamin D Receptor Signaling in Breast Cancer

Abstract

Kombinovaný bio informatický a literární přístup k identifikaci dlouhých nekódujících molekul RNA, které modulují signalizaci přes receptor vitaminu D u karcinomu prsu Kholghi Oskooei V., Ghafouri-Fard S., Omrani MD Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran SummaryBackground: Long non-cod ing RNAs (lncRNAs) as an important fraction of human transcriptome have been shown to exert fundamental role in regulation of signal ing pathways implicated in carcinogenesis. Among them is vitamin D receptor (VDR) signal ing whose participation in various cancers includ ing breast cancer (BC) is evident. In spite of the presence of several evidences for participation of lncRNAs as well as VDR signal ing in BC pathogenesis, no comprehensive study has evaluated the link between lncRNA dysregulation and VDR signal ing in BC. Aim: To introduce a bio informatics approach for identification of lncRNAs that modulate VDR signal ing in BC. This approach includes co-expression analysis, in silico identification of lncRNAs that target VDR and literature search. Conclusions: Tens of lncRNAs are predicted to affect VDR signaling. Among them are some lncRNAs such as MALAT1 which has prominent role in BC pathogenesis. Identification of the lncRNAs that influence VDR gene expression is possible through in silico analysis. Consider ing the prominent role of VDR in BC pathogenesis as well as availability of VDR modulat ing agents, evaluation of VDR signal ing pathway and related networks are of practical significance and bio informatics tools are expected to facilitate such action.

Vitamin D in Triple-Negative and BRCA1-Deficient Breast Cancer—Implications for Pathogenesis and Therapy

“…Some of these lncRNAs exert their effect in breast cancer through their interaction with microRNAs [99,100]. Some lncRNAs may regulate vitamin D metabolism and 1,25(OH)2D controls the expression of some miRNAs, which, in turn, regulate the mRNAs of genes involved in breast carcinogenesis [101][102][103].…”

A Newly Identified lncBCAS1-4_1 Associated With Vitamin D Signaling and EMT in Ovarian Cancer Cells

“…Previous reports demonstrated that 1a,25(OH) 2 D 3 could regulate some protein-coding genes (31)(32)(33). Three studies showed that VDR regulated lncRNA profiling in skin and breast cancer (24)(25)(26). However, to date, there was no study investigating whether 1a,25(OH) 2 D 3 could affect the expression pattern of lncRNAs in ovarian cancer.…”

“…These findings indicate that 1a,25(OH) 2 D 3 may play an important role in the control of cancer by mediating protein-coding genes. In addition, one and two reports studied vitamin D receptor (VDR)-regulated lncRNAs profiling in skin cancer and breast cancer, respectively (24)(25)(26). However, it is not clear which lncRNAs are regulated by 1a,25(OH) 2 D 3 in ovarian cancer.…”

Expression analysis of vitamin D receptor-associated long noncoding RNAs in patients with relapsing-remitting multiple sclerosis

“…According to the literature, certain polymorphisms in the VDR gene have been linked to an elevated risk of several autoimmune diseases, including MS (2,4). More recently, it has been found that the expression of the VDR gene is infl uenced by a number of long noncoding RNAs (lncRNAs) (5).…”