A combined approach to extract rotational dynamics of globular proteins undergoing liquid-liquid phase separation
Dominik Gendreizig,
Abhishek Kalarikkal,
Simon L. Holtbrügge
et al.
Abstract:The formation of protein condensates (droplets) via liquid-liquid phase separation (LLPS) is a commonly observed phenomenon in vitro. Changing the environmental properties with cosolutes, molecular crowders, protein partners, temperature, pressure, etc. was shown to favour or disfavour the formation of protein droplets by fine-tuning the water-water, water-protein and protein-protein interactions. Therefore, these environmental properties and their spatiotemporal fine-tuning are likely to be important also in … Show more
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