A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum

Quignodon, Laure; Grijota-Martínez, Carmen; Compe, Emmanuel; Guyot, Romain; Allioli, Nathalie; Laperrière, David; Walker, Robert L.; Meltzer, Paul S.; Mader, Sylvie; Samarut, Jacques; Flamant, Frédéric

doi:10.1677/jme-06-0054

Cited by 35 publications

(26 citation statements)

References 65 publications

(43 reference statements)

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“…A global analysis of TH target genes has not been performed in the adult mammalian retina. However, in the adult rodent brain, relatively few TH-dependent genes have been identified, with no apparent involvement of components of the chromatin modification pathway (Quignodon et al, 2007). This opens the possibility that transactivators of S-and M-opsin with regulatory function during early development also play a role for the maintenance of opsin identity in mature cones.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Glaschke¹,

Weiland²,

Turco³

et al. 2011

J. Neurosci.

103

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Mammalian retinas display an astonishing diversity in the spatial arrangement of their spectral cone photoreceptors, probably in adaptation to different visual environments. Opsin expression patterns like the dorsoventral gradients of short-wave-sensitive (S) and middle-to long-wave-sensitive (M) cone opsin found in many species are established early in development and thought to be stable thereafter throughout life. In mouse early development, thyroid hormone (TH), through its receptor TR␤2, is an important regulator of cone spectral identity. However, the role of TH in the maintenance of the mature cone photoreceptor pattern is unclear. We here show that TH also controls adult cone opsin expression. Methimazole-induced suppression of serum TH in adult mice and rats yielded no changes in cone numbers but reversibly altered cone patterns by activating the expression of S-cone opsin and repressing the expression of M-cone opsin. Furthermore, treatment of athyroid Pax8 Ϫ/Ϫ mice with TH restored a wild-type pattern of cone opsin expression that reverted back to the mutant S-opsin-dominated pattern after termination of treatment. No evidence for cone death or the generation of new cones from retinal progenitors was found in retinas that shifted opsin expression patterns. Together, this suggests that opsin expression in terminally differentiated mammalian cones remains subject to control by TH, a finding that is in contradiction to previous work and challenges the current view that opsin identity in mature mammalian cones is fixed by permanent gene silencing.

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Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Glaschke¹,

Weiland²,

Turco³

et al. 2011

J. Neurosci.

103

View full text Add to dashboard Cite

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“…Several attempts to identify target genes that are directly regulated by thyroid hormone during brain development have been made with limited success (Dong et al, 2005;Quignodon et al, 2007a;Diez et al, 2008;Royland et al, 2008). As one obstacle, the (G/A)GGT(C/G)A consensus sequence of the TRE that usually contains this motif as two half sites arrayed as either direct repeats spaced by four nucleotides, inverted repeats spaced by six nucleotides or as palindromes (reviewed in Yen, 2001) is quite frequent, and bioinformatic approaches usually will reveal a large number of them.…”

Section: Molecular Targets Of Thyroid Receptorsmentioning

confidence: 99%

“…Candidates for such a function are BTEB (Denver and Williamson, 2009), hairless (hr) (Potter et al, 2002), NeuroD (Chantoux and Francon, 2002), RORalpha (Koibuchi and Chin, 1998) and NGFI-A (Egr1) (Mellstrom et al, 1994). Moreover, recent approaches to identify further thyroid hormone regulated gene products in the brain using microarray analysis revealed additional T3 target genes (Poguet et al, 2003;Dong et al, 2005;Quignodon et al, 2007a;Diez et al, 2008). However, their exact function during neuronal differentiation still needs to be established.…”

Section: Molecular Targets Of Thyroid Receptorsmentioning

confidence: 99%

Thyroid hormone action during brain development: More questions than answers

Horn

Heuer

2010

Molecular and Cellular Endocrinology

173

109

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“…Finally, THs influence the expression of cytoskeletal components, important mediators of morphological differentiation, as well as axonal and dendritic outgrowth (Silva and Rudas, 1990;Aniello et al, 1991a;Aniello et al, 1991b;Lorenzo et al, 2002). Only in a few examples has it been possible to assign the control of gene expression to a specific receptor subtype (Calza et al, 2000;Abel et al, 2001;Quignodon et al, 2007;Diez et al, 2008). Finally, a recent study identified the TR 1 binding sites and target genes in the developing mouse cerebellum through the use of the ChIP-onChIP technology (Dong et al, 2009).…”

Section: Gene Regulationmentioning

confidence: 99%

Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

Kress

Samarut

Plateroti

2009

Molecular and Cellular Endocrinology

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Thyroid hormones and the control of cell proliferation or cell differentiation: paradox or duality?. Molecular and Cellular Endocrinology, Elsevier, 2009, 313 (1-2) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. SummaryAmphibian metamorphosis perfectly illustrates a key paradox: thyroid hormones control diverse cellular processes depending on the tissue context. This point is also reinforced by a recent accumulation of evidence. For example, thyroid hormones and their nuclear receptor TRs have been described to function in different systems in synergy and/or in antagonism with other signaling pathways. This interaction helps explain their pleiotropic roles. This review summarizes the most important advances in this field, focusing in particular on the key action of thyroid hormones in controlling the balance between the processes of cell proliferation and cell differentiation in a few organs, with special attention paid to the intestine. We highlight similarities between the cellular and molecular events occurring during postnatal intestinal maturation at metamorphosis in amphibians, and comparable events observed at weaning in mice. 1-Introduction1.1 Thyroid hormone production Thyroid hormones (THs), L-thyroxine or T4 and 3,5,3'-L-triiodothyronine or T3, are essential for the development of several organs, including the central nervous system, skeleton, heart, intestine, skeletal muscle and sensory organs. Moreover, they also have important regulatory effects on oxygen consumption and metabolic rate (Oppenheimer et al., 1987). The follicular cells of the thyroid gland synthesize and secrete both hormones, but T4 is the most abundant. This process is under the control of circulating THs levels through the hypothalamuspituitary-thyroid feedback regulatory loop (rev. in Fredric and Wondisford, 2004). The intracellular concentration of T3 is dependent upon the uptake of T3 and T4, and their subsequent metabolism (Bianco and Kim, 2006). In fact, both hormones are actively transported across the cell membrane by specific transporter proteins, of which monocarboxylate transporter-8 is the best characterized (Dumitrescu et al., 2004;Friesema et al., 2004; rev. in Refetoff andDumitrescu, 2007 andVisser et al., 2007). Three iodothyronine deiodinase selenoenzymes (D1, D2 and D3) regulate TH activation and catabolism (Bianco and Kim, 2006). D1 and D2 catalyze the 5'-deiodination of T4 to its active metabolite T3. T3 is generated from the activity of D1, which is the main source of circulating T3. In contrast, D2 is the isoenzyme primarily responsible for local production of T3 in target cells. T3 derived from ...

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A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum

Cited by 35 publications

References 65 publications

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Thyroid Hormone Controls Cone Opsin Expression in the Retina of Adult Rodents

Thyroid hormone action during brain development: More questions than answers

Thyroid hormones and the control of cell proliferation or cell differentiation: Paradox or duality?

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