A combined accelerator mass spectrometry/positron emission tomography microdose study to assess the plasma and brain tissue pharmacokinetics of 11C- and 14C-labelled verapamil in healthy volunteers

Wagner, Cláudia; Simpson, Marie; Lappin, Graham; Karch, Rudolf; Abrahim, Aiman; Feurstein, Thomas; Bauer, Martin; Zeitlinger, Markus; Kletter, Kurt; Müller, Markus; Langer, Oliver

doi:10.1186/1471-2210-8-s1-a49

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“…In a small study, Wagner et al measured the pharmacokinetic (PK) data of verapamil in plasma and brain by means of combined PET and AMS analysis using 11 C-and 14 C-labeled verapamil, respectively. Both methodologies showed linearity in PK data of verapamil within the employed dose range, thereby suggesting the utility of combining PET and AMS for obtaining precise plasma and PK data of target drugs [25].…”

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confidence: 99%