A Combination of Virgin Coconut Oil and Extra Virgin Olive Oil Elicits Superior Protection Against Doxorubicin Cardiotoxicity in Rats

Utari, Andi Ulfiana; Djabir, Yulia Yusrini; Palinggi, Bogie Putra

doi:10.4274/tjps.galenos.2021.37998

Cited by 3 publications

(4 citation statements)

References 33 publications

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“…Chronic liver disorders and muscular injuries led to increasing SGPT levels [ 53 ]. This might explain why the measured values were greater in the first two intervals, demonstrating the prevalence of muscular atrophy followed by recovery stratification.…”

Section: Discussionmentioning

confidence: 99%

Physiotherapeutic Protocol and ZnO Nanoparticles: A Combined Novel Treatment Program against Bacterial Pyomyositis

El-Shaer

Elwakil

Bakr

et al. 2022

Biology

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Myositis tropicans or pyomyositis is a muscle inflammation resulting from a bacterial infection of skeletal muscle (commonly caused by Staphylococcus aureus) that usually leads to hematogenous muscle seeding. The present study was designed to estimate the role of ZnO-NPs and a physiotherapeutic program in the management of induced biceps femoris atrophy in rats through histological, biochemical, and radiological examinations at different time intervals. At the beginning, several bacterial strains were evaluated through a proteolytic enzyme activity assay and the highest activity was recorded with the Staphylococcus aureus strain. ZnO-NPs were synthesized with the arc discharge method with an average size of 19.4 nm. The antibacterial activity of ZnO-NPs was investigated and it was revealed that the prepared ZnO-NPs showed a minimum inhibitory concentration of 8 µg/mL against the tested bacterium. The cytotoxicity of the prepared ZnO-NPs was tested in C2C12 myoblast cells, and it was elaborated that CC50 was 344.16 µg/mL. Biceps femoris pyomyositis was induced with a potent strain (Staphylococcus aureus); then, a physiotherapeutic program combined with the prepared ZnO-NPs treatment protocol was applied and evaluated. The combined program claimed antibacterial properties, preventing muscle atrophy, and resulted in the most comparable value of muscle mass.

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Section: Discussionmentioning

confidence: 99%

Physiotherapeutic Protocol and ZnO Nanoparticles: A Combined Novel Treatment Program against Bacterial Pyomyositis

El-Shaer

Elwakil

Bakr

et al. 2022

Biology

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“…Different ratios of EVOO-VCO combinations may result in different cardioprotective effects. Previously, Utari et al (2022) showed that an EVOO-VCO combination in a 1:1 ratio was superior in inhibiting myocardial injury in DOX-induced rats compared to either EVOO or VCO alone. The EVOO-VCO combination was believed to have a synergistic effect in inhibiting cellular damage and death [13].…”

Section: Histopathological Analysismentioning

confidence: 99%

“…Previously, Utari et al (2022) showed that an EVOO-VCO combination in a 1:1 ratio was superior in inhibiting myocardial injury in DOX-induced rats compared to either EVOO or VCO alone. The EVOO-VCO combination was believed to have a synergistic effect in inhibiting cellular damage and death [13]. EVOO and VCO are plant-based oils with very different chemical compounds and FA profiles.…”

Section: Histopathological Analysismentioning

confidence: 99%

“…Additionally, a preclinical study reported that a single administration of VCO had a cardioprotective effect against cardiac remodelling and blood pressure elevation [12]. The protective effects of EVOO and VCO in combination were shown to be superior against oxidative stress in multiple organs in doxorubicin-treated rats [13]. The study showed that the combination could prevent the development of myocardial injury after doxorubicin injection [14].…”

Section: Introductionmentioning

confidence: 99%

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The Cardioprotective Effect of Extra Virgin Olive Oil and Virgin Coconut Oil on Isoproterenol-Induced Myocardial Infarction in Rats

NADIAH¹

2023

FARMACIA

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Routine consumption of extra virgin olive oil (EVOO) and virgin coconut oil (VCO) may improve cardiovascular function. This study examined the cardioprotective effect of the combination of EVOO and VCO on isoproterenol-induced myocardial infarction in rats. Rats (n = 30) were divided into five groups: a healthy group, an isoproterenol group without treatment, and three treatment groups that were given an EVOO-VCO combination at 1:1, 1:2 and 2:1 (2 mL/200 g) orally for 14 days before injecting isoproterenol (100 mg/kg) for two consecutive days. After 24 hours, blood samples were taken to analyse cardiac biomarkers, and the heart was examined for histopathological changes. Isoproterenol injection caused a substantial increase in the creatine kinase-myocardial band, lactate dehydrogenase and aspartate aminotransferase levels. Pretreatment with an EVOO-VCO combination in all ratios significantly reduced these biomarker levels (p < 0.05). Myocardial damage was significantly reduced, especially with the EVOO-VCO combination of 2:1. In conclusion, the EVOO-VCO combination significantly reduced cardiac injury biomarker levels and improved myocardial structure in isoproterenol-induced myocardial infarction in rats. The EVOO-VCO combination of 2:1 was superior in preserving myocardial structure compared to the other ratios. RezumatConsumul uleiului de măsline extravirgin (EVOO) și a uleiului de cocos virgin (VCO) poate îmbunătăți funcția cardiovasculară. Acest studiu a examinat efectul cardioprotector al combinației de EVOO și VCO asupra infarctului miocardic indus de izoproterenol la șobolani. Șobolanii (n = 30) au fost împărțiți în cinci grupuri: un grup sănătos, un grup de izoproterenol fără tratament și trei grupuri de tratament cărora li s-a administrat o combinație de EVOO-VCO în proporție de 1:1, 1:2 și 2:1 (2 mL/200 g) pe cale orală timp de 14 zile înainte de injectarea de izoproterenol (100 mg/kg) timp de două zile consecutive. După 24 de ore, au fost prelevate probe de sânge pentru a analiza biomarkerii cardiaci, iar la nivelul inimii au fost examinate modificările histopatologice. Administrarea de izoproterenol a provocat o creștere substanțială a nivelurilor de creatin-kinază miocardică, lactat dehidrogenază și aspartat aminotransferază. Pretratarea cu o combinație EVOO-VCO, în toate proporțiile, a redus semnificativ aceste niveluri ale biomarkerilor (p < 0,05). Leziunile miocardice au fost diminuate, în special la administrarea combinației EVOO-VCO 2:1. În concluzie, asocierea EVOO-VCO a redus semnificativ nivelurile biomarkerilor cardiaci și a îmbunătățit structura miocardului în modelul experimental ales. Combinația EVOO-VCO de 2:1 a fost superioară în ceea ce privește conservarea structurii miocardice în comparație cu celelalte proporții.

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Doxorubicin-mediated cardiac dysfunction: Revisiting molecular interactions, pharmacological compounds and (nano)theranostic platforms

2023

Environmental Research

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A Combination of Virgin Coconut Oil and Extra Virgin Olive Oil Elicits Superior Protection Against Doxorubicin Cardiotoxicity in Rats

Cited by 3 publications

References 33 publications

Physiotherapeutic Protocol and ZnO Nanoparticles: A Combined Novel Treatment Program against Bacterial Pyomyositis

Physiotherapeutic Protocol and ZnO Nanoparticles: A Combined Novel Treatment Program against Bacterial Pyomyositis

The Cardioprotective Effect of Extra Virgin Olive Oil and Virgin Coconut Oil on Isoproterenol-Induced Myocardial Infarction in Rats

Doxorubicin-mediated cardiac dysfunction: Revisiting molecular interactions, pharmacological compounds and (nano)theranostic platforms

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