A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial

Rajendiran, Ethendhar; Lamarche, Benoı̂t; She, Yongbo; Ramprasath, Vanu Ramkumar; Eck, Peter; Brassard, Didier; Gigleux, Iris; Lévy, Émile; Tremblay, Angelo; Couture, Patrick; House, James D.; Jones, Peter J H; Desmarchelier, Charles

doi:10.1093/ajcn/nqab064

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…A 2‐step approach was followed, combining dimension reduction by univariate filtering followed by PLS regression, as has been previously applied with SNPs. [ 22 , 29 , 30 ] The step of univariate filtering consisted of selecting SNPs that showed a p ‐value < 0.05 (Wald test asymptotic p ‐value) following analysis with PLINK (v1.07, http://pngu.mgh.harvard.edu/purcell/plink/ ), which is an open‐source online toolset designed to perform tests that determine level of association between genotypic and phenotypic data. A PLS regression model including all thus selected variables coded in units of variance was then built.…”

Section: Methodsmentioning

confidence: 99%

The Interindividual Variability of Phytofluene Bioavailability is Associated with a Combination of Single Nucleotide Polymorphisms

Zumaraga

Borel

Bott

et al. 2022

Molecular Nutrition Food Res

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Scope Phytofluene is a colorless carotenoid with potential health benefits that displays a higher bioavailability compared to carotenoids such as lutein, β‐carotene or lycopene. Several studies suggest its bioavailability displays an elevated interindividual variability. The aim of this work is to investigate whether a combination of SNPs is associated with this variability. Methods and Results Thirty‐seven healthy adult males consume a test meal that provides phytofluene from a tomato puree. Phytofluene concentrations are measured at fast and in chylomicrons at regular time intervals after meal intake. Identification of the combination of SNPs that best explained the interindividual variability of the phytofluene response is assessed by partial least squares regression. There is a large interindividual variability in the phytofluene response, with CV = 88%. Phytofluene bioavailability is positively correlated with fasting plasma phytofluene concentration (r = 0.57; p = 2 × 10−4). A robust partial least squares regression model comprising 14 SNPs near or within 11 genes (ABCA1‐rs2487059, rs2515629, and rs4149316, APOC1‐rs445925, CD36‐rs3211881, ELOVL5‐rs6941533, FABP1‐rs10185660, FADS3‐rs1000778, ISX‐rs130461, and rs17748559, LIPC‐rs17240713, LPL‐rs7005359, LYPLAL1‐rs1351472, SETD7‐rs11936429) explains 51% (adjusted R2) of the interindividual variability in phytofluene bioavailability. Conclusions This study reports a combination of SNPs that is associated with a significant part of the interindividual variability of phytofluene bioavailability in a healthy male adult population.

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Section: Methodsmentioning

confidence: 99%

The Interindividual Variability of Phytofluene Bioavailability is Associated with a Combination of Single Nucleotide Polymorphisms

Zumaraga

Borel

Bott

et al. 2022

Molecular Nutrition Food Res

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Identification of different lipoprotein response types in people following a Mediterranean diet pattern with and without whole eggs

Picklo

Rust²,

Yeater³

et al. 2022

Nutrition Research

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A Review of Low-Density Lipoprotein-Lowering Diets in the Age of Anti-Sense Technology

Nestel

Mori

2023

Nutrients

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This narrative review discusses an important issue, the primary role of diet in reducing low-density lipoprotein cholesterol (LDLc) concentrations in polygenic hypercholesterolemia. Two effective drugs, statins, and ezetimibe, that lower LDLc > 20% are relatively inexpensive and potential competitors to strict dieting. Biochemical and genomic studies have shown that proprotein convertase subtilisin kexin type 9 (PCSK9) plays an important role in low-density lipoprotein (LDL) and lipid metabolism. Clinical trials have demonstrated that inhibitory monoclonal antibodies of PCSK9 dose-dependently lower LDLc up to 60%, with evidence of both regression and stabilization of coronary atherosclerosis and a reduction in cardiovascular risk. Recent approaches using RNA interference to achieve PCSK9 inhibition are currently undergoing clinical evaluation. The latter presents an attractive option of twice-yearly injections. They are, however, currently expensive and unsuitable for moderate hypercholesterolemia, which is largely due to inappropriate patterns of eating. The best dietary approach, the substitution of saturated fatty acids by polyunsaturated fatty acids at 5% energy, yields > 10% lowering of LDLc. Foods such as nuts and brans, especially within a prudent, plant-based diet low in saturates complemented by supplements such as phytosterols, have the potential to reduce LDLc further. A combination of such foods has been shown to lower LDLc by 20%. A nutritional approach requires backing from industry to develop and market LDLc-lowering products before pharmacology replaces the diet option. Energetic support from health professionals is vital.

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A combination of single nucleotide polymorphisms is associated with the interindividual variability in the blood lipid response to dietary fatty acid consumption in a randomized clinical trial

Cited by 3 publications

References 43 publications

The Interindividual Variability of Phytofluene Bioavailability is Associated with a Combination of Single Nucleotide Polymorphisms

The Interindividual Variability of Phytofluene Bioavailability is Associated with a Combination of Single Nucleotide Polymorphisms

Identification of different lipoprotein response types in people following a Mediterranean diet pattern with and without whole eggs

A Review of Low-Density Lipoprotein-Lowering Diets in the Age of Anti-Sense Technology

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