A combination of platelet‐derived and insulin‐like growth factors enhances periodontal regeneration

Abstract

The combination of platelet-derived growth factor (PDGF) and insulin-like growth factor one (IGF-1) has previously been shown to enhance repair of soft tissue wounds. Here we report initial observations following application of PDGF and IGF-1 to periodontitis-affected teeth in beagle dogs. 1 micrograms of PDGF and IGF-1 in an aqueous gel was applied to the root surfaces of test teeth following open flap debridement. Control sites received the gel alone. Block biopsies of the teeth and surrounding bone were taken 2 weeks after treatment. Histologic analyses of control specimens revealed a long junctional epithelial attachment, and no new bone or cementum formation. In contrast, growth factor treated sites exhibited significant amounts of new bone and cementum formation. A nearly continuous layer of osteoblasts lined the newly formed bone, and there was a dense cellular "front" at the coronal extent of the new bone. These preliminary results suggest that in vivo application of the combination of PDGF and IGF-1 may enhance regeneration of the periodontal structures.

Growth factor delivery for oral and periodontal tissue engineering

“…PDGF-BB is the most effective on PDL cell mitogenesis and matrix biosynthesis [75,76]. Several preclinical studies were performed using the combination of PDGF-BB and IGF-I for periodontal and peri-implant bone regeneration [77][78][79][80][81][82], culminating in the first study in humans using growth factors for periodontal regeneration [83]. In a human Phase I/II clinical trial, PDGF/IGF-I were considered safe when applied topically to periodontal osseous lesions, resulting in a significant improvement in bone growth and fill of periodontal defects, compared with standard therapy [83].…”

Aplicación de biomateriales de base biológica, moléculas bioactivas e ingeniería de tejidos en cirugía plástica periodontal: Una revisión

“…Los factores de crecimiento derivados de plaquetas (FCDP) ha sido el factor de crecimiento más estudiado en periodoncia desde que se descubrió que tenía el potencial regenerativo tisular (47) . Con base en estos descubrimientos, la versión humana recombinada de este material (hrFCDP-BB) ha sido igualmente investigada demostrando su eficacia regenerativa tanto en animales como en humanos (48,49) .…”

Periodontal regeneration in deep intrabony periodontal defect using hydroxyapatite particles with platelet rich fibrin membrane–a case report

“…These growth factors have been shown to play an important role in growth and differentiation of the cells involved in the periodontal wound healing. 5,6 In the case described here, the PRF membrane combined with the HA particles was used for the intrabony defect to assess if the regeneration of a new bone was possible.…”