A combination of photodynamic therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review

Pérez-Laguna, Vanesa; Gilaberte, Yolanda; Millán-Lou, María Isabel; Agut, Montserrat; Nonell, Santi; Rezusta, Antonio; Hamblin, Michael R.

doi:10.1039/c8pp00534f

Cited by 85 publications

(59 citation statements)

References 36 publications

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“…An experimental study with 21 PLWHA showed that fluconazole did not prevent recurrence of oral candidiasis when they were reevaluated within 30 days, whereas in patients receiving PDT, there was no recurrence of the lesion during the same reevaluation period 14 . The combination of PDT and fluconazole was effective in reducing C. albicans colonies in in vitro 10,11 and in vivo 12,13 studies. In this study, participants 015 and 018, respectively, received PDT/nystatin and PDT/ fluconazole exhibited a reduction in oral candidiasis severity ratings when reassessed after 14 days.…”

Section: Discussionmentioning

confidence: 95%

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Antimicrobial efficacy of photodynamic therapy on the treatment of oral candidiasis in people living with hiv/aids

Izoton

Israel

2020

R.pesq.:cuid.fundam.Online

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Objetivo: Avaliar a eficácia antimicrobiana da terapia fotodinâmica no tratamento da candidíase oral em pessoas vivendo com HIV/aids. Método: Estudo experimental, qualitativo e descritivo com 18 pessoas vivendo com HIV/aids que manifestavam a candidíase oral, maiores de 18 anos, que estavam em tratamento no Hospital Universitário Gaffrée e Guinle. Este grupo subdividiu-se em um grupo controle, composto por sete pessoas, que recebeu tratamento com a terapia fotodinâmica e antifúngicos, e um grupo experimental, com 11, que recebeu apenas a terapia fotodinâmica. A evolução do tratamento de cada participante foi acompanhada por registros fotográficos em duas consultas, inicial e final. Esta pesquisa foi aprovada pelo Comitê de Ética em Pesquisa do hospital, parecer número 2.431.107. Resultados: A maioria dos participantes apresentou melhora clínica, ainda que discreta, e em apenas um houve piora clínica. Conclusão: A terapia fotodinâmica antimicrobiana pode ser eficaz no tratamento da candidíase oral em pessoas vivendo com HIV/aids.

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Section: Discussionmentioning

confidence: 95%

“…This technique has shown to be promising in reducing C. albicans colonies in in vitro [9][10][11] and in vivo 12,13 assays. PDT was also effective in the treatment of oral candidiasis in PLWHA, without causing side effects, both isolated 14 and when associated with topical antifungals 15 .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial efficacy of photodynamic therapy on the treatment of oral candidiasis in people living with hiv/aids

Izoton

Israel

2020

R.pesq.:cuid.fundam.Online

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“…In the management of cancer, PDT has been used to deliver localized bursts of cytotoxic O 2 to tissues marked for destruction [91]. It has also been studied for antimicrobial use in skin and mucosal infections with success [92,93]. Fan et al described its use to deliver 5-aminolevulinic acid for the treatment of rosacea, a chronic skin condition with unknown pathogenesis [94].…”

Section: Phototherapeuticsmentioning

confidence: 99%

Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease

Wickenheisser

Zywot

Rabjohns

et al. 2019

Curr Allergy Asthma Rep

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Purpose of Review-The goal of this review is to summarize the field to date and to discuss strengths and limitations of low-level laser (light) therapy (LLLT) for the future investigation as a treatment of inflammatory disease. Recent Findings-LLLT is a promising therapeutic, particularly for those diseases of skin and joints because they are most accessible to treatment. Indeed, the known mechanisms of LLLT support its use for anti-inflammatory purposes, as well as stimulation of tissue growth and repair. Although the standard of care for the majority of inflammatory diseases is immunosuppressive agents such as corticosteroids with undesirable toxicities, LLLT offers a unique approach by being non-invasive and incurring minimal side effects. It is also relatively inexpensive and accessible and even has the possibility to be patient directed at home. Summary-There is evidence that LLLT is able to modulate the immune system at the skin and joint, and it has been shown to be efficacious in humans by affecting bacterial colonization as it may pertain to chronic rhinosinusitis. However, there is variability in the methods of laser application as well as a lack of evidence for laser type, dose-ranging studies, and wavelength selection that create barriers to the implementation of LLLT without further more rigorous and standardized study. The heterogeneity makes it difficult to draw strong conclusions about the efficacy of LLLT and its mechanisms.

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“…An emerging strategy to fight hospital-acquired infections is the so-called antimicrobial photodynamic inactivation (aPDI) (14)(15)(16)(17). This approach has been developed in parallel with the photodynamic therapy (PDT) of cancer (18,19), although in recent times it has attracted a renewed interest (14,15,(20)(21)(22)(23)(24)(25)(26). It is based on the killing of microorganisms by reactive oxygen species (ROS), for instance singlet oxygen and radicals, which in turn are generated due to the absorption of light by a photosensitizer in the presence of oxygen.…”

Section: Introductionmentioning

confidence: 99%

Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal

et al. 2021

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New strategies to fight bacteria and fungi are necessary in view of the problem of iatrogenic and nosocomial infections combined with the growing threat of increased antimicrobial resistance. Recently, our group has prepared and described two new readily available materials based on the combination of Rose Bengal (singlet oxygen photosensitizer) and commercially available cationic polystyrene (macroporous resin Amberlite® IRA 900 or gel-type resin IRA 400). These materials showed high efficacy in the antimicrobial photodynamic inactivation (aPDI) of Pseudomonas aeruginosa. Here, we present the photobactericidal effect of these polymers against an extended group of pathogens like Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and the opportunistic yeast Candida albicans using green light. The most interesting finding is that the studied materials are able to reduce the population of both Gram-positive and Gram-negative bacteria with good activity, although, for C. albicans, in a moderate manner. In view of the results achieved and especially considering the inexpensiveness of these two types of photoactive polymers, we believe that they could be used as the starting point for the development of coatings for self-disinfecting surfaces.

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A combination of photodynamic therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review

Abstract: aPDT combined with antimicrobials could be promising to manage skin and mucosal infections.

Cited by 85 publications

References 36 publications

Antimicrobial efficacy of photodynamic therapy on the treatment of oral candidiasis in people living with hiv/aids

Antimicrobial efficacy of photodynamic therapy on the treatment of oral candidiasis in people living with hiv/aids

Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease

Broad-Spectrum Photo-Antimicrobial Polymers Based on Cationic Polystyrene and Rose Bengal

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