A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine model

Lee, Young-Sil; Ryu, Hyung Won; Yang, Won‐Kyung; Park, Mi Hyeon; Park, Yang-Chun; Kim, Doo-Young; Kwon, Hanjung; Kim, Soo‐Young; Oh, Sei‐Ryang; Kim, Seung-Hyung

doi:10.1016/j.phymed.2020.153407

Cited by 11 publications

(11 citation statements)

References 41 publications

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“…Spirodela polyrhiza extract (SPE) and OLE (Olea europaea leaf extract) have positive effects on AD symptoms. Treatment with both OLE and SPE as a combined mixture has been reported to improve pruritus and epidermal hyperplasia, stabilize the immune response (reduction of the inflammatory and allergenic cell infiltration and cytokine levels), reduce the levels of IgE and histamine, and restore skin barrier function (up-regulation of expression of skin barrier proteins) [ 52 ]. Aquaphilus dolomiae extract-G1 has been reported to modulate the inflammatory response (stimulates IL-8 and reduces CCL20 expression), augment the activities of antimicrobial peptides (stimulates DEFB4 and A100A7) and enhance barrier function through the restoration of filaggrin expression [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review

Katsarou

Makris

Vakirlis

et al. 2023

JCM

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Background: Tight junctions are transmembrane proteins that regulate the permeability of water, solutes including ions, and water-soluble molecules. The objective of this systematic review is to focus on the current knowledge regarding the role of tight junctions in atopic dermatitis and the possible impact on their therapeutic potential. Methods: A literature search was performed in PubMed, Google Scholar, and Cochrane library between 2009 and 2022. After evaluation of the literature and taking into consideration their content, 55 articles were finally included. Results: TJs’ role in atopic dermatitis extends from a microscopic scale to having macroscopic effects, such as increased susceptibility to pathogens and infections and worsening of atopic dermatitis features. Impaired TJ barrier function and skin permeability in AD lesions is correlated with cldn-1 levels. Th2 inflammation inhibits the expression of cldn-1 and cldn-23. Scratching has also been reported to decrease cldn-1 expression. Dysfunctional TJs’ interaction with Langerhans cells could increase allergen penetration. Susceptibility to cutaneous infections in AD patients could also be affected by TJ cohesion. Conclusions: Dysfunction of TJs and their components, especially claudins, have a significant role in the pathogenesis and vicious circle of inflammation in AD. Discovering more basic science data regarding TJ functionality may be the key for the use of specific/targeted therapies in order to improve epidermal barrier function in AD.

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Section: Resultsmentioning

confidence: 99%

The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review

Katsarou

Makris

Vakirlis

et al. 2023

JCM

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“…Understanding more about the heart of AD pathogenesis – skin inflammation – was critical to the treatment approach 19 . IFN‐ γ and TNF‐ α belonged to one of the Th1‐type cytokines, which activated macrophages to induce AD, while IL‐4 and IL‐13 belonged to one of the Th2‐type cytokines, which induced the differentiation of mast cells and eosinophils and promoted the production of immunoglobulin E, thus inducing the inflammatory response of AD 20 . To investigate whether FOS ameliorates AD by modulating the IgE and Th1 and Th2‐associated cytokines in a model of AD, we measured the serum level of IgE and skin levels of IFN‐ γ , TNF‐ α , IL‐4, and IL‐13.…”

Section: Resultsmentioning

confidence: 99%

“…2 Moreover, the Th2-dominated cytokines, IL-4 and IL-13 could enhance the release of histamine, IL-31 and thymic stromal lymphopoietin (TSLP) through IL-4R in sensory nerves, thus leading to the intense pruritus. 25 γ-Interferon secreted by Th1 cells could activate macrophages to induce AD, 20 which is also associated with AD-like skin lesions and intense pruritus. In contrast, the present study showed that, after FOS administration, the frequency of scratching behavior in mice was reduced, and serum IgE, as well as skin levels of CD4 + T cells, IL-4, IFN-γ, and TNF-⊍ were significantly reduced, inhibiting the vicious cycle and alleviating AD.…”

Section: Discussionmentioning

confidence: 99%

Fructo‐oligofructose ameliorates 2,4‐dinitrofluorobenzene‐induced atopic dermatitis‐like skin lesions and psychiatric comorbidities in mice

et al. 2023

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BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritus and eczema lesions and psychiatric comorbidities. The gut–brain–skin axis plays a pivotal role during AD development, which might suggest a novel therapeutic strategy for AD. The present study aims to uncover the protective effects and underlying mechanisms of fructo‐oligofructose (FOS), a type of prebiotic, on AD‐like skin manifestations and comorbid anxiety and depression in AD mice. RESULTS Female Kunming mice were treated topically with 2,4‐dinitrofluorobenzene (DNFB) to induce AD‐like symptoms and FOS was administered daily for 14 days. The results showed that FOS could alleviate AD‐like skin lesions markedly as evidenced by dramatic decreases in severity score, scratching bouts, the levels of immunoglobulin E (IgE) and T helper 1(Th1)/Th2‐related cytokines, and the infiltration of inflammatory cells and mast cells to the dermal tissues. The comorbid anxiety and depressive‐like behaviors, estimated by the forced swimming test (FST), the tail‐suspension test (TST), the open‐field test (OFT), and the zero maze test (ZMT) in AD mice, were significantly attenuated by FOS. Fructo‐oligofructose significantly upregulated brain neurotransmitters levels of 5‐hydroxytryptamine (5‐HT) and dopamine (DA). Furthermore, FOS treatment increased the relative abundance of gut microbiota, such as Prevotella and Lactobacillus and the concentrations of short‐chain fatty acids (SCFAs), especially acetate and iso‐butyrate in the feces of AD mice. The correlation analysis indicated that the reshaped gut microbiome composition and enhanced SCFAs formation are associated with skin inflammation and behavioral alteration. CONCLUSION Collectively, these data identify FOS as a promising microbiota‐targeted treatment for AD‐like skin inflammation and comorbid anxiety and depressive‐like behaviors. © 2023 Society of Chemical Industry.

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“…An AD-like mouse model was usually established by inducing DNCB. The performance of mouse model is considered to be similar to that of clinical patients [ 31 ]. In this study, a mixture of 1% DNCB, acetone and olive oil was prepared to establish the model.…”

Section: Discussionmentioning

confidence: 99%

Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis

Zhang

Shao

et al. 2022

Chin Med

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Background Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied with itchy and scaly rash. Compound traditional Chinese medicine dermatitis ointment (CTCMDO) consists of a mixture of extracts from five plants, which had been used in AD treatment due to good anti-inflammatory and anti-allergic effects. Materials and methods In this study, high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometer (LC/MS) were performed to analyze the active ingredients of CTCMDO in detail and to establish its HPLC fingerprint. Furthermore, the anti-inflammatory and antipruritic activities of CTCMDO were studied in the treatment of DNCB-induced AD in mice. Results A total of 44 compounds including phenylpropionic acid compounds, alkaloid compounds, curcumin compounds and lignans were identified via combined HPLC and LC/MS. A fingerprint with 17 common peaks was established. In AD-like mice, DNCB-induced scratching behavior had been suppressed in the treatment of CTCMDO in a dose-dependent manner. Furthermore, the detailed experimental results indicated that the AD can be effectively improved via inhibiting the production of Th1/2 cytokines in serum, reversing the upregulation of substance P levels of itch-related genes in the skin, and suppressing the phosphorylation of JNK, ERK, and p38 in the skin. Conclusion This work indicated that CTCMDO can significantly improve AD via attenuating the pathological alterations of Th1/2 cytokines and itch-related mediators, as well as inhibiting the phosphorylation of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB).

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A combination of Olea europaea leaf extract and Spirodela polyrhiza extract alleviates atopic dermatitis by modulating immune balance and skin barrier function in a 1-chloro-2,4-dinitrobenzene-induced murine model

Cited by 11 publications

References 41 publications

The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review

The Role of Tight Junctions in Atopic Dermatitis: A Systematic Review

Fructo‐oligofructose ameliorates 2,4‐dinitrofluorobenzene‐induced atopic dermatitis‐like skin lesions and psychiatric comorbidities in mice

Compound traditional Chinese medicine dermatitis ointment ameliorates inflammatory responses and dysregulation of itch-related molecules in atopic dermatitis

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