A combination of Vitreoscilla filiformis extract and Vichy volcanic mineralizing water strengthens the skin defenses and skin barrier

Abstract

Probiotics are live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host. Semiactive, non‐replicating bacteria or extracts used in dermocosmetics have interesting properties for skin quality. Vitreoscilla filiformis is cultured by a fermentation process to obtain an extract. It is considered as a probiotic fraction and topical application of this extract has shown activity to strengthen the skin physical barrier function and maintain good homeostasis of skin defenses. Vichy volcanic mineralizing water (VVMW) is a pure, highly mineralized water that has been shown to strengthen the skin against exposome aggressions. This manuscript reviews properties of probiotic fractions used in skin care, especially studies on an extract of V. filiformis grown in a medium containing VVMW (VfeV) and evaluated in combination with VVMW. Skin barrier function: In normal human epidermal keratinocyte cultures, the combination of 10% VVMW and 0.002% VfeV significantly increased transglutaminase, filaggrin, involucrin, claudin‐1, and zonula occludens‐1 in comparison with the controls. Antimicrobial peptide defenses: The combination of 16.7% VVMW and 0.1% VfeV increased the expression of β‐defensin‐4A and S100A7. Skin immune defense functions: In lipopolysaccharide‐stimulated peripheral blood mononuclear cells, the combination of 16.7% VVMW and 0.1% VfeV down‐regulated IL‐8, TNF‐α, IL‐12/IL‐23p40, and increased IL10 and IL‐10/IL‐12 ratio compared to the control. Additionally, the combination of 79% VVMW plus 5% VfeV protected Langerhans cells in skin explants exposed to ultraviolet radiation. In conclusion, the combination of VfeV plus VVMW has properties to strengthen the skin barrier by stimulating skin differentiation and tight junctions, biochemical defenses by stimulating antimicrobial peptides, and cellular immune defenses by increasing the IL‐10/IL‐12 ratio and by protecting Langerhans cells challenged by ultraviolet radiation.

A Randomized, Controlled Clinical Trial of a Dermocosmetic Containing Vichy Volcanic Mineralizing Water and Probiotic Fractions in Subjects with Rosacea Associated with Erythema and Sensitive Skin and Wearing Protective Masks

“… 20 , 29 In vitro studies showed that in normal human epidermal keratinocyte cultures, the combination of 10% VVMW and 0.002% VfeV significantly increased transglutaminase, filaggrin, involucrin, claudin-1, and zonula occludens-1 in comparison with the controls. 21 Tocopherol or vitamin E is a well-known antioxidant. 30 Niacinamide has anti-oxidant and anti-inflammatory properties and reduces oedema.…”

“…Recently, two investigations confirmed the benefit of M89PF in the management of acute stressed skin. 21 , 22 …”

Highlights from the Journal of the European Academy of Dermatology and Venereology in 2022

“…Current research on atopic dermatitis is also focusing on the role of the cutaneous microbiome and a Swiss group has recently discovered an increased fungal diversity in severe atopic dermatitis 23 . Additionally, topical application of commensal bacteria, such as Vitreoscilla filiformis, appears to be beneficial for certain patients 24 . New kinase inhibitors, especially Janus kinase inhibitors, have been introduced to the market; Abrocitinib, together with Upadacitinib and Baricitinib, broaden the therapeutic spectrum 25 …”

“…23 Additionally, topical application of commensal bacteria, such as Vitreoscilla filiformis, appears to be beneficial for certain patients. 24 New kinase inhibitors, especially Janus kinase inhibitors, have been introduced to the market; Abrocitinib, together with Upadacitinib and Baricitinib, broaden the therapeutic spectrum. 25 As well, emollient application on newborns continues to be a topic of debate in terms of primary prevention.…”

The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro

“…In a study to explore the effect of Lactobacillus rhamnosus on the reconstruction of skin barrier function in human epidermal model, it was found that Lactobacillus rhamnosus lysate reduced the cytotoxicity of a skin irritant (sodium lauryl sulfate), and enhanced the protection of skin barrier 18 . The application of Vitreoscilla filiformis fermentation extract on the skin not only strengthens the skin barrier, but also enhances the immune defense 19 . As one of the most common microorganisms in probiotics, Bifidobacterium is also an important source of probiotic strains 16,20 .…”