A Combination of flk1-Based DNA Vaccine and an Immunomodulatory Gene (IL-12) in the Treatment of Murine Cancer

Feng, Keke; Zhao, Hongyang; Qiu, Haijun; Liu, Jixiao; Chen, Jian

doi:10.1089/1084978042484795

Cited by 9 publications

(5 citation statements)

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“…Although the utility of live vaccines in eradication of salmonellosis is limited, there is vast potential for their use as vector for DNA vaccines and as recombinant antigens [12,[80][81][82][83][84][85][86][87][88][89][90] which might lead to evolution of multivalent vaccines in coming decades ( Table 3). Recombinant DNA technology combined with defined gene deletion method for attenuation has made it feasible to develop vaccines against a broad range of human and animal pathogens.…”

Section: Future Of Live Vaccinesmentioning

confidence: 99%

“…The benefits of such recombinant vaccines lie in their multivalent nature which might work against many types of tumor cells simultaneously. The use of vaccines as therapy to treat cancer could potentially have several advantages over conventional therapies that directly target tumors [84,89]. A DNA vaccine encoding secretory chemokine CCL21 and an inhibitor of apoptosis protein survivin could be delivered orally through doubly attenuated S.Typhimurium (damand aroA -) mutant.…”

Section: Antigens For Contraceptionmentioning

confidence: 99%

“…Therefore, oral vaccine against tetanus developed through cloning of DNA coding for an immunogenic nontoxic fraction of tetanus toxin into an attenuated Salmonella strain proved more efficacious than any other type of tetanus vaccine. Many antigens of immunogenic potential for control of parasitic [72,[105][106][107][108][109][110][111][112], bacterial [80-82, 85-86, 90, 113-134] and viral [81,83,[135][136][137][138][139][140][141][142][143][144][145] infections, tumor growth [73,74,84,[86][87][88][89] and also for contraception [146,147] have already been expressed in attenuated Salmonella strains, a step towards development of multivalent mucosal vaccines ( Table 3). Studies revealed that Salmonella vaccines as vector for DNA and plasmid-vectored vaccines bear a vast potential.…”

Section: Future Of Salmonella Vaccines As Mucosal Vaccinesmentioning

confidence: 99%

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Salmonella Vaccines for Animals and Birds and Their Future Perspective

Singh¹

2009

TOVACJ

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Vaccines are the most powerful biologicals which have modulated the economic, social and cultural life of human beings. Certain diseases have haunted humanity for centuries but are now extinct due to vaccines. On the other hand, some diseases such as salmonellosis, that were uncontrollable in the past, still cause pandemics today. There are more than 2500 serovars of Salmonella and vaccines made from any one serovar do not confer cross-protection against another, no matter how much antigenic similarity there is between the two. Salmonella strains are able to cause disease and to adapt to different types of animals whilst still maintaining their zoonotic and interspecies transfer potential. Three major types of vaccines are being used to control salmonellosis: killed bacteria, subunit vaccines and live attenuated vaccines. Effective vaccines against some host adapted and common serovars have been developed but their use has led to the emergence of other serovars. The problem has become more complex because increased international trade and travel has helped Salmonella strains to cross continental boundaries. It seems unlikely that we will be able to develop an effective Salmonella vaccine in the near future that is able to control all forms of salmonellosis, even in a single animal species. Recent advances in Salmonella vaccines will be reviewed including the use of Salmonella as vector for delivery of multivalent DNA and recombinant vaccines for controlling salmonellosis and other infectious diseases as well as for the control of cancer.

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Section: Future Of Live Vaccinesmentioning

confidence: 99%

Section: Antigens For Contraceptionmentioning

confidence: 99%

Section: Future Of Salmonella Vaccines As Mucosal Vaccinesmentioning

confidence: 99%

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Salmonella Vaccines for Animals and Birds and Their Future Perspective

Singh¹

2009

TOVACJ

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“…Primary locations include mucosal surfaces, under the skin, and other areas likely to be faced with foreign antigen entry . The most typical delivery routes include oral, ,− intranasal, intramuscular, , subcutaneous, intraperitoneal, ,, and intravenous . Of these delivery routes, oral administration is common and offers the advantages of simple, noninvasive administration and, therefore, better potential patient compliance.…”

Section: Target Cells: Apcsmentioning

confidence: 99%

Engineering Bacterial Vectors for Delivery of Genes and Proteins to Antigen-Presenting Cells

Parsa

Pfeifer

2007

Mol. Pharmaceutics

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Bacterial vectors offer a biological route to gene and protein delivery with this article featuring delivery to antigen-presenting cells (APCs). Primarily in the context of immune stimulation against infectious disease or cancer, the goal of bacterially mediated delivery is to overcome the hurdles to effective macromolecule delivery. This review will present several bacterial vectors as macromolecule (protein or gene) delivery devices with both innate and acquirable (or engineered) biological features to facilitate delivery to APCs. The review will also present topics related to large-scale manufacture, storage, and distribution that must be considered if the bacterial delivery devices are ever to be used in a global market.

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“…RIT combined with gene therapy (GT) has been shown to enhance efficacy of cancer therapy due to the potential additive or synergetic effects of cytokines [12][13][14]. Thus, the local expression of cytokine-induced cellular immune response to tumors has become a focus of biological therapy for cancer [15][16][17]. We thus investigated in this study whether the combination of LLC vaccine containing IL-12 DNA and the lung cancer Mab LC-1 labeled with 131 I on C57BL/6 mice subcutaneous tumor models enhanced efficacy compared to each agent given alone.…”

Section: Introductionmentioning

confidence: 99%