A Combination of Amodiaquin and Primaquine (Camoprim) in the Prevention and Cure of Sporozoite-Induced Chesson Strain Vivax Malaria

The chemotherapy of malaria

“…1,2 For prevention of malaria in individuals or in well-disciplined groups such as military personnel residing temporarily or traveling in malarious areas, administration of a combination of a 4-aminoquinoline and primaquine weekly provides one means for obtaining prophylaxis against malaria more satisfactory than that afforded by the use of a 4aminoquinoline alone. A combination of 30 to 45 mg. of primaquine base and 300 mg. of chloroquine base (or an equivalent amount of amodiaquine 63 ) administered weekly can be employed to prevent malaria in travelers; when used for this purpose, combined administration of both drugs should be continued weekly for 8 weeks after the last exposure to infection. 2 The weekly concurrent administration of 300 mg. of chloroquine base and 45 mg. of primaquine base" 95 constitutes a prophylactic antimalarial regimen currently employed by the United States Armed Forces.…”

“…The chemotherapy of malaria 63 The administration of 300 mg. of chloroquine or amodiaquine base and 45 mg. of primaquine base weekly for 8 weeks can be employed as an alternate measure, rather than administration of 15 mg. of primaquine daily for 14 days, for treatment of persons returning from malaria-infested regions."' 2 For the treatment of nonimmune adults who have developed acute attacks caused by P. vivax after exposure to Southwest Pacific or New Guinea vivax malaria, 300 mg. of chloroquine or amodiaquine base and 45 mg. of primaquine base can be administered weekly for 8 weeks, in an effort to prevent relapses, after termination of the acute attacks by administration of appropriate doses of a 4-aminoquinoline 1 , 2; although the regimen involving administration of 45 mg. of primaquine base weekly for 8 weeks may be more effective for obtaining radical cure of infections with the Chesson strain of P. vivax than is the regimen involving administration of 15 mg. of primaquine base daily for 14 days,r neither regimen is invariably effective in completely eradicating secondary tissue schizonts of this strain of P. vivax.…”