A Colorimetric Chemical Sensing Platform for Real-Time Monitoring of Indoor Formaldehyde

Qin, Xingcai; Wang, Rui; Tsow, Francis; Forzani, Erica; Xian, Xiaojun; Tao, Nongjian

doi:10.1109/jsen.2014.2364142

Cited by 27 publications

(24 citation statements)

References 13 publications

(17 reference statements)

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“…However, currently no sensing system is available to researchers which can continuously monitor an individual patient's exposure to formaldehyde and correlate it with the patient's symptoms and physiological responses. Formaldehyde sensors based on metal oxide technology and colorimetric assays have been developed before [23][24][25], but not in wearable formats suitable for real-life monitoring. In addition, to make large-scale epidemiological studies feasible, it's likely a cloud-based IoT-like system is required to handle large-scale sensor deployment, management, data storage, and analytics [26][27][28][29][30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

A wearable IoT aldehyde sensor for pediatric asthma research and management

Dong

Downen

et al. 2019

Sensors and Actuators B: Chemical

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Mechanistic studies of pediatric asthma require objective measures of environmental exposure metrics correlated with physiological responses. Here we report a cloud-based wearable IoT sensor system which can measure an asthma patient's exposure to aldehydes, a known class of airway irritants, in real-life settings. The wrist-watch shaped sensor can measure formaldehyde levels in air from 30ppb to 10ppm using fuel cell technology, and continuously operate over 7 days without recharging. The sensor wirelessly uploads data to an Android smartphone via Bluetooth Low Energy (BLE). The smartphone also functions as a gateway to a cloud-based informatics system which handles sensor data storage, management and analytics. Potential applications of this IoT sensor system include epidemiological studies of asthma development and exacerbations, personalized asthma management and environmental monitoring.

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Section: Introductionmentioning

confidence: 99%

A wearable IoT aldehyde sensor for pediatric asthma research and management

Dong

Downen

et al. 2019

Sensors and Actuators B: Chemical

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“…Particularly, a real-time and low-cost detector is required for the general public to verify the safety of their surrounding environments. Colorimetric sensors using a sensing material that changes color when reacting with HCHO were proposed [11][12][13][14][15][16][17][18][19][20][21][22]. Hydroxylamine sulfate with pH indicator, 4-amino hydrazine-5-mercapto-1,2,4-triazole (AHMT), fluoral-P, and -diketones have proven to be successful HCHO-sensing materials exhibiting high selectivity and ppb-regime sensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…Identifying the color change using naked eye, however, is not reliable. In addition to using the conventional absorbance spectrometer, several groups have attempted to design low-cost and miniaturized systems to provide reliable color reading [15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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A low-cost miniaturized colorimetric sensor with vertically-stacked semi-transparent finger-type organic photo detector for formaldehyde sensing

Lin

Zan

et al. 2019

Organic Electronics

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We proposed a sensitive colorimetric sensing system using a paper-like sensing layer on top of a vertically stacked finger-type organic photodetector (OPD) and commercial light-emitting diode (LED). The stacked OPD/LED device was small, with an area of 0.8 cm × 0.5 cm that was even smaller than a coin. Using commercial colorimetric formaldehyde (HCHO) sensing molecules to form the sensing layer, the stacked detecting system successfully detected HCHO of concentrations ranging from 40 to 1000 ppb within 20 min. Critical parameters affecting the sensitivity were investigated. The final system exhibited a stable calibration curve over 60 days. The long lifetime was attributed to using 2,6-Bis(trimethyltin)-4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo [1,2-b :4,5-b' ]dithio phene (PBDTTT-C-T) : phenyl-C71-butyric acid methyl ester (PC 71 BM) to serve as a blended system and using the current variation ratio to represent the sensing response.

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“…5–8 Many techniques have been developed to detect HCHO, including spectrophotometric, 9 electrochemical, 10,11 optical, 12 electronic, 13 and colorimetric 14 methods. Sensitive detection of urine HCHO by chromatography-mass spectrometry methods is known.…”

Section: Introductionmentioning

confidence: 99%

Pyrenyl carbon nanostructures for ultrasensitive measurements of formaldehyde in urine

Premaratne

Farias

Krishnan

2017

Analytica Chimica Acta

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Measurement of ultra-low (e.g., parts-per-billion) levels of small-molecule markers in body fluids (e.g., serum, urine, saliva) involves a considerable challenge in view of designing assay strategies with sensitivity and selectivity. Herein we report for the first time an amperometric nano-bioelectrode design that uniquely combines 1-pyrenebutyric acid units pi-pi stacked with carboxylated multiwalled carbon nanotubes on the surface of gold screen printed electrodes for covalent attachment of NAD+ dependent formaldehyde dehydrogenase (FDH). The designed enzyme bioelectrode offered 6 ppb formaldehyde detection in 10-times diluted urine with a wide dynamic range of 10 ppb to 10 ppm. Fourier transform infrared, Raman, and electrochemical impedance spectroscopic characterizations confirmed the successful design of the FDH bioelectrode. Flow injection analysis provided lower detection limit and greater affinity for formaldehyde (apparent KM 9.6 ± 1.2 ppm) when compared with stirred solution method (apparent KM 19.9 ± 4.6 ppm). Selectivity assays revealed that the bioelectrode was selective toward formaldehyde with a moderate cross-reactivity for acetaldehyde (~ 25%) and negligible cross-reactivity toward propanaldehyde, acetone, methanol, and ethanol. Formaldehyde is an indoor pollutant, and studies have indicated neurotoxic characteristics and systemic toxic effects of this compound upon chronic and high doses of exposure. Moreover, reported chromatography and mass spectrometry methods identified elevated urine formaldehyde levels in patients with bladder cancer, dementia, and early stages of cognitive impairments compared to healthy people. Results demonstrate that pyrenyl carbon nanostructures-based FDH bioelectrode design represents novelty and simplicity for enzyme-selective electrochemical quantitation of small 30 Da formaldehyde. Broader applicability of the presented approach for other small-molecule markers is feasible that requires only the design of appropriate marker-specific enzyme systems or receptor molecules.

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A Colorimetric Chemical Sensing Platform for Real-Time Monitoring of Indoor Formaldehyde

Cited by 27 publications

References 13 publications

A wearable IoT aldehyde sensor for pediatric asthma research and management

A wearable IoT aldehyde sensor for pediatric asthma research and management

A low-cost miniaturized colorimetric sensor with vertically-stacked semi-transparent finger-type organic photo detector for formaldehyde sensing

Pyrenyl carbon nanostructures for ultrasensitive measurements of formaldehyde in urine

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