A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds

Hormesis: A General Biological Principle

“…5 Hormesis can guide studies to optimize timing and dosing of drug administration to prevent and treat diseases, improve healthspan, and extend lifespan. 2,3,5 While these advancements make it clear that hormesis affects organisms from the molecular to the individual organism, this dose−response framework also affects evolutionary survivalbased selection. It indicates a conserved strategy of organisms to precondition and protect themselves by regulating molecules within a concentration gradient framework as well as via sensing chemical cues of other organisms.…”

“…While toxicologists are familiar with hormesis, recent developments in different disciplines now highlight its broader relevance to biology, offering a perspective for further interdisciplinary research to better understand how hormesis affects evolution, environmental science, public health, and medicine. Hormesis can enhance the survival, health, productivity, and reproduction of plants, animals, and microbes while protecting them against more severe stress within time-sensitive periods, some of which have an anticipatory component. − It can also protect postharvest plant products against various stressors, enhance their quality, prolong their storability, and enrich phytochemicals production . Hormesis is one of the eight hallmarks of health, selected based on its association with the healthy state, absence of pathogenic features, capacity to restore health following disease or injury, and support of broad pro-health activities .…”

“…It affects molecules (e.g., reactive chemical species and antioxidants), organelles (mitochondrial hormesis), cells (e.g., stem cells), supracellular units (specific tissues), organs (preventing brain damage), organ systems, systemic circuitries (induction by endocrine, immune, metabolic, and neural pathways), and meta-organism effects (e.g., microbiota and immune responses) . Hormesis can guide studies to optimize timing and dosing of drug administration to prevent and treat diseases, improve healthspan, and extend lifespan. ,, …”

Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging

“…Is a flavonol and is a common ingredient in most marketed dietary supplements or foods in the world. Close to what has previously been discussed for other natural products, quercetin can also prolong the median lifespan in diverse model organisms when administered late in life ( Saul et al, 2008 ; Proshkina et al, 2016 ; Berkel and Cacan, 2021 ). Various evidence from basic studies suggests its therapeutic potential in age-related diseases such as neurodegenerative diseases, degenerative joint disorders, cardiovascular diseases, metabolic diseases, etc., ( El-Sayed et al, 2021 ; Grewal et al, 2021 ; Dhanya, 2022 ).…”

Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice

“…Cellular models have enlightened the senolytic properties of curcumin. Curcumin appears to increase the lifespan of D. melanogaster and C. elegans ( 119 ). Also, curcumin exerts its senolytic activity through the activation of Nrf2, reduction of NF-κB activation, and reduction of proinflammatory cytokines expression.…”