A collagen-based hydrogel containing tacrolimus for bone tissue engineering

Nabavi, Mir Hamed; Salehi, Majid; Ehterami, Arian; Bastami, Farshid; Semyari, Hassan; Tehranchi, Maryam; Nabavi, Mir Ahmad; Semyari, H

doi:10.1007/s13346-019-00666-7

Cited by 53 publications

(36 citation statements)

References 59 publications

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“…More recently, collagen I-based hydrogel has been validated for drug-release usage as reported by Nabavi and colleagues. Indeed, their tests in rat model, using tacrolimus-loaded collagen hydrogel, reported appropriate scaffold porosity, swelling and drug release [76].…”

Section: Natural Polymersmentioning

confidence: 99%

“…Facilitate pore interconnectivity good porosity, cell infiltration, cell differentiation, angiogenesis and osteogenesis [69][70][71][72][73][74] Appropriate scaffold porosity, swelling, and drug release [75,76] Increased osteogenic potential [83] Increased compressive strenght of bone cement; increased prolifertion and osteogenic differantiation [87,88] [82] [128][129][130][131][132] Increased cellular attachment, angiogenesys, and osteogenesis [130,131] [ 126,127] PLA Good cell adhesion proliferation, and osteo-differentiation [134,136] Rapid and complete drug release, good cell viability, proliferation, and osteogenic differentiation [136] [ 133,135] PLGA Good porosity, osteogenic potential, and mineralization activity, higher cellular adhesion/proliferatio, and new bone formation [137][138][139][140][141][142]144,145][143] 1 Higher initial adhesion, increased proliferation, new bone formation, and suitable scaffold integration; controlled drug release. [144,147,148] Good cell viability, proliferation, and osteogenic differentiation [145] [146]…”

Section: Collagenmentioning

confidence: 99%

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Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.

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Section: Natural Polymersmentioning

confidence: 99%

Section: Collagenmentioning

confidence: 99%

Natural and Synthetic Polymers for Bone Scaffolds Optimization

et al. 2020

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“…Low mechanical strength is not conducive to bearing compression and pull from external forces, and a fast degradation rate goes against cell differentiation and cartilage repair. [13][14][15][16][17][18] Moreover, the hydrophilic collagen scaffolds have difficulty loading hydrophobic drugs uniformly, which limits the application of collagen scaffold materials in drug loading and sustained release. 19,20 In addition, currently most of the prepared collagen scaffolds consist of singlepore structures, which do not satisfy the pore requirements for the multi-scale porous structures of cartilage.…”

Section: Introductionmentioning

confidence: 99%

Sodium alginate/collagen composite multiscale porous scaffolds containing poly(ε-caprolactone) microspheres fabricated based on additive manufacturing technology

Liu

Huang

et al. 2020

RSC Adv.

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“…It was reported by Luo et al 54 and Kanda et al 55 that administration of TAC as an immunosuppressant drug had a negative impact on bone structure with increased bone resorption without significantly affecting bone formation. However, a recent study conducted by Nabavi et al 56 demonstrated preliminary evidence on the efficacy of TAC loaded hydrogel for the treatment of bone defects by decreasing levels of inflammatory mediators and improving osteogenic differentiation. According to our results, free TAC showed a minute effect on the bone formation biomarkers.…”

Section: Resultsmentioning

confidence: 99%

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

Helal¹,

Samy²,

Kamoun³

et al. 2021

IJN

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Background: Tacrolimus (TAC) is a powerful immunosuppressive agent whose therapeutic applicability is confined owing to its systemic side effects. Objective: Herein, we harnessed a natural polymer based bioconjugate composed of maltodextrin and α-tocopherol (MD-α-TOC) to encapsulate TAC as an attempt to overcome its biological limitations while enhancing its therapeutic anti-rheumatic efficacy. Methods: The designed TAC loaded maltodextrin-α-tocopherol nano-micelles (TAC@MDα-TOC) were assessed for their physical properties, safety, toxicological behavior, their ability to combat arthritis and assist bone/cartilage formation. Results: In vitro cell viability assay revealed enhanced safety profile of optimized TAC@MD-α-TOC with 1.6-to 2-fold increase in Vero cells viability compared with free TAC. Subacute toxicity study demonstrated a diminished nephro-and hepato-toxicity accompanied with optimized TAC@MD-α-TOC. TAC@MD-α-TOC also showed significantly enhanced anti-arthritic activity compared with free TAC, as reflected by improved clinical scores and decreased IL-6 and TNF-α levels in serum and synovial fluids. Unique bone formation criteria were proved with TAC@MD-α-TOC by elevated serum and synovial fluid levels of osteocalcin and osteopontin mRNA and proteins expression. Chondrogenic differentiation abilities of TAC@MD-α-TOC were proved by increased serum and synovial fluid levels of SOX9 mRNA and protein expression. Conclusion: Overall, our designed bioconjugate micelles offered an excellent approach for improved TAC safety profile with enhanced anti-arthritic activity and unique bone formation characteristics.

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A collagen-based hydrogel containing tacrolimus for bone tissue engineering

Cited by 53 publications

References 59 publications

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Natural and Synthetic Polymers for Bone Scaffolds Optimization

Sodium alginate/collagen composite multiscale porous scaffolds containing poly(ε-caprolactone) microspheres fabricated based on additive manufacturing technology

Potential Privilege of Maltodextrin-α-Tocopherol Nano-Micelles in Seizing Tacrolimus Renal Toxicity, Managing Rheumatoid Arthritis and Accelerating Bone Regeneration

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