A Collaborative Study of the Emergence and Clinical Features of the Major Depressive Syndrome of Alzheimer’s Disease

Zubenko, George S.; Zubenko, Wendy N.; McPherson, Susan; Spoor, Eleanor; Marin, Deborah B.; Farlow, Martin R.; Smith, Glenn E.; Geda, Yonas E.; Cummings, Jeffrey L.; Petersen, Ronald C.; Sunderland, Trey

doi:10.1176/appi.ajp.160.5.857

Cited by 257 publications

(215 citation statements)

References 36 publications

Supporting

Mentioning

194

Contrasting

Unclassified

Order By: Relevance

“…4 Both vascular dementia and AD are associated with a higher prevalence of depression. 49,50 Depression frequently occurs in the early stages of AD and may result from both cell loss in key areas of the brain controlling emotions as well as a psychological reaction to cognitive loss. 4 Vascular changes such as white matter hyperintensities are a risk factor for both depression 51,52 and dementia, 53 and are associated with a high prevalence of depression in cross-sectional studies 54 .…”

Section: Discussionmentioning

confidence: 99%

Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort Study

et al. 2010

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort Study

et al. 2010

View full text Add to dashboard Cite

“…Late onset depression and cognitive impairment often occur together, suggesting a close association between them [Jorm, 2001;Zubenko et al, 2003].…”

Section: Discussionmentioning

confidence: 99%

Depression among elderly patients admitted to a sub-acute medical care and rehabilitation center in Bahrain

Saeed

Abulsaad

Mahmoud³

et al. 2016

Int Arch Med

View full text Add to dashboard Cite

Background: Depression is common among community indwelling elderly. It is even more common among in-patients. Depressed elderly individuals have a poorer quality of life, lower rehabilitation success, and a higher mortality. The aim of the current study is to assess the prevalence of depressive symptoms and associated factors in elderly patients admitted in a Rehabilitation and sub-acute medical care center in Bahrain.Method: All elderly patients 60 years old and over, admitted to the center during a 6 month period were included in the study. Geriatric depression scale (GDS), Mini-mental State exam (MMSE), Barthel activities of daily living (ADL) Index, and a medical and social history were obtained from each patient. Further evaluation of depression using Diagnostic and Statistical Manual of Mental Disorders -IV (DSM-IV) criteria was done for each patient with positive GDS. Results:The study included all 51 elderly admitted to the center in 6 months, 23 females (45.1%) and 28 males (54.9%) with a mean age of 75.59±9.32 (60-95). The prevalence of depression was found to be 39.2% with no statistically significant gender difference. There was a positive correlation between the severity of depressive symptoms and age, poor functional status, and poor cognitive function. Conclusion:There is a high rate of depression among elderly patients admitted to medical facilities with significant association with the functional and cognitive capacity of the elderly. Depression is under estimated and further studies in our region are needed to assess the prevalence and detection rate in different health care settings.

show abstract

“…Significant depressive symptoms and mood changes are reported in 20%-30% of cases with early-stage AD (Zubenko et al 2003). Agitation, psychosis, and anxiety are not typically seen in these initial stages (Geldmacher 2009), and become increasingly more common with disease progression.…”

Section: Initial Presentation (Very Mild and Mild Ad)mentioning

confidence: 99%

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

Tarawneh

Holtzman

2012

Cold Spring Harbor Perspectives in Medicine

315

181

View full text Add to dashboard Cite

Alzheimer disease (AD) is the most common cause of dementia in the elderly. Clinicopathological studies support the presence of a long preclinical phase of the disease, with the initial deposition of AD pathology estimated to begin approximately 10-15 years prior to the onset of clinical symptoms. The hallmark clinical phenotype of AD is a gradual and progressive decline in two or more cognitive domains, most commonly involving episodic memory and executive functions, that is sufficient to cause social or occupational impairment. Current diagnostic criteria can accurately identify AD in the majority of cases. As disease-modifying therapies are being developed, there is growing interest in the identification of individuals in the earliest symptomatic, as well as presymptomatic, stages of disease, because it is in this population that such therapies may have the greatest chance of success. The use of informant-based methods to establish cognitive and functional decline of an individual from previously attained levels of performance best allows for the identification of individuals in the very mildest stages of cognitive impairment.

show abstract

A Collaborative Study of the Emergence and Clinical Features of the Major Depressive Syndrome of Alzheimer’s Disease

Cited by 257 publications

References 36 publications

Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort Study

Comorbid Depression Is Associated with an Increased Risk of Dementia Diagnosis in Patients with Diabetes: A Prospective Cohort Study

Depression among elderly patients admitted to a sub-acute medical care and rehabilitation center in Bahrain

The Clinical Problem of Symptomatic Alzheimer Disease and Mild Cognitive Impairment

Contact Info

Product

Resources

About